BDBM50498452 CHEMBL3596873

SMILES: CC(C)(C)c1cc(NC(=O)Nc2cccc(Oc3cncc(n3)-c3ccc(cc3)S(C)(=O)=O)c2)no1

InChI Key: InChIKey=MAGVRNDWTTZRHB-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50498452   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ephrin type-B receptor 2 (Homo sapiens (Human))	BDBM50498452 (CHEMBL3596873) Show SMILES CC(C)(C)c1cc(NC(=O)Nc2cccc(Oc3cncc(n3)-c3ccc(cc3)S(C)(=O)=O)c2)no1 Show InChI InChI=1S/C25H25N5O5S/c1-25(2,3)21-13-22(30-35-21)29-24(31)27-17-6-5-7-18(12-17)34-23-15-26-14-20(28-23)16-8-10-19(11-9-16)36(4,32)33/h5-15H,1-4H3,(H2,27,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Inhibition of EphB2 (unknown origin) using ATP and 5FAM tagged TrkA peptide substrate incubated for 60 mins by microfluidics assay				Medchemcomm 5: 1507-1514 (2014) Article DOI: 10.1039/c4md00251b BindingDB Entry DOI: 10.7270/Q2WW7MQ5
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50498452 (CHEMBL3596873) Show SMILES CC(C)(C)c1cc(NC(=O)Nc2cccc(Oc3cncc(n3)-c3ccc(cc3)S(C)(=O)=O)c2)no1 Show InChI InChI=1S/C25H25N5O5S/c1-25(2,3)21-13-22(30-35-21)29-24(31)27-17-6-5-7-18(12-17)34-23-15-26-14-20(28-23)16-8-10-19(11-9-16)36(4,32)33/h5-15H,1-4H3,(H2,27,29,30,31)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Inhibition of RET (unknown origin) using ATP and 5FAM tagged TrkA peptide substrate incubated for 60 mins by microfluidics assay				Medchemcomm 5: 1507-1514 (2014) Article DOI: 10.1039/c4md00251b BindingDB Entry DOI: 10.7270/Q2WW7MQ5
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50498452 (CHEMBL3596873) Show SMILES CC(C)(C)c1cc(NC(=O)Nc2cccc(Oc3cncc(n3)-c3ccc(cc3)S(C)(=O)=O)c2)no1 Show InChI InChI=1S/C25H25N5O5S/c1-25(2,3)21-13-22(30-35-21)29-24(31)27-17-6-5-7-18(12-17)34-23-15-26-14-20(28-23)16-8-10-19(11-9-16)36(4,32)33/h5-15H,1-4H3,(H2,27,29,30,31)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	92	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Inhibition of human recombinant TrkA using ATP and 5FAM tagged TrkA peptide substrate incubated for 60 mins by microfluidics assay				Medchemcomm 5: 1507-1514 (2014) Article DOI: 10.1039/c4md00251b BindingDB Entry DOI: 10.7270/Q2WW7MQ5
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50498452 (CHEMBL3596873) Show SMILES CC(C)(C)c1cc(NC(=O)Nc2cccc(Oc3cncc(n3)-c3ccc(cc3)S(C)(=O)=O)c2)no1 Show InChI InChI=1S/C25H25N5O5S/c1-25(2,3)21-13-22(30-35-21)29-24(31)27-17-6-5-7-18(12-17)34-23-15-26-14-20(28-23)16-8-10-19(11-9-16)36(4,32)33/h5-15H,1-4H3,(H2,27,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
The University of Arizona Curated by ChEMBL					Assay Description Inhibition of KDR (unknown origin) using ATP and 5FAM tagged TrkA peptide substrate incubated for 60 mins by microfluidics assay				Medchemcomm 5: 1507-1514 (2014) Article DOI: 10.1039/c4md00251b BindingDB Entry DOI: 10.7270/Q2WW7MQ5
					More data for this Ligand-Target Pair