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BDBM50500104 CHEMBL3739592

SMILES: OC(=O)c1ccc(NC(c2ccccn2)c2ccc3cccnc3c2O)cc1

InChI Key: InChIKey=JMHUSAZRQVDCAK-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50500104   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prenyl protein specific protease


(Homo sapiens (Human))		BDBM50500104
PNG
(CHEMBL3739592)
Show SMILES OC(=O)c1ccc(NC(c2ccccn2)c2ccc3cccnc3c2O)cc1
Show InChI InChI=1S/C22H17N3O3/c26-21-17(11-8-14-4-3-13-24-19(14)21)20(18-5-1-2-12-23-18)25-16-9-6-15(7-10-16)22(27)28/h1-13,20,25-26H,(H,27,28)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.80E+4n/an/an/an/an/an/a



New York University Abu Dhabi

Curated by ChEMBL


Assay Description
Inhibition of human Rce1-mediated CaaX protease activity using ABZ-KSKTKC(farnesyl)QIIM and ABZ-KSKTKC(farnesyl)VIQI as substrate assessed as residua...

Bioorg Med Chem 24: 160-78 (2016)


Article DOI: 10.1016/j.bmc.2015.11.043
BindingDB Entry DOI: 10.7270/Q2NS0XXQ
More data for this
Ligand-Target Pair