BDBM50500367 CHEMBL3747226

SMILES: FC(F)(F)c1cccc(NC(=O)n2ccc3cc(Oc4ncnc5CNCCc45)ccc23)c1

InChI Key: InChIKey=FKMYXQCCIDUXCG-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50500367   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50500367 (CHEMBL3747226) Show SMILES FC(F)(F)c1cccc(NC(=O)n2ccc3cc(Oc4ncnc5CNCCc45)ccc23)c1 Show InChI InChI=1S/C23H18F3N5O2/c24-23(25,26)15-2-1-3-16(11-15)30-22(32)31-9-7-14-10-17(4-5-20(14)31)33-21-18-6-8-27-12-19(18)28-13-29-21/h1-5,7,9-11,13,27H,6,8,12H2,(H,30,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of Tel-fused KDR (unknown origin) expressed in mouse BaF3 cells using poly(Glu,Tyr) as substrate after 10 mins by scintillation counting a...				J Med Chem 58: 9273-86 (2015) Article DOI: 10.1021/acs.jmedchem.5b01227 BindingDB Entry DOI: 10.7270/Q26M39T9
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50500367 (CHEMBL3747226) Show SMILES FC(F)(F)c1cccc(NC(=O)n2ccc3cc(Oc4ncnc5CNCCc45)ccc23)c1 Show InChI InChI=1S/C23H18F3N5O2/c24-23(25,26)15-2-1-3-16(11-15)30-22(32)31-9-7-14-10-17(4-5-20(14)31)33-21-18-6-8-27-12-19(18)28-13-29-21/h1-5,7,9-11,13,27H,6,8,12H2,(H,30,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of KDR (unknown origin)				J Med Chem 58: 9273-86 (2015) Article DOI: 10.1021/acs.jmedchem.5b01227 BindingDB Entry DOI: 10.7270/Q26M39T9
					More data for this Ligand-Target Pair
1,3-beta-glucan synthase component GLS2 (Saccharomyces cerevisiae)	BDBM50500367 (CHEMBL3747226) Show SMILES FC(F)(F)c1cccc(NC(=O)n2ccc3cc(Oc4ncnc5CNCCc45)ccc23)c1 Show InChI InChI=1S/C23H18F3N5O2/c24-23(25,26)15-2-1-3-16(11-15)30-22(32)31-9-7-14-10-17(4-5-20(14)31)33-21-18-6-8-27-12-19(18)28-13-29-21/h1-5,7,9-11,13,27H,6,8,12H2,(H,30,32)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of human ERG channel by automated Q-patch assay				J Med Chem 58: 9273-86 (2015) Article DOI: 10.1021/acs.jmedchem.5b01227 BindingDB Entry DOI: 10.7270/Q26M39T9
					More data for this Ligand-Target Pair