BDBM50500372 CHEMBL3745943

SMILES: CC(C)c1cc(NC(=O)n2ccc3cc(Oc4ncnc5CNCCc45)ccc23)n[nH]1

InChI Key: InChIKey=AMLGSOPRYBWTJD-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50500372   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50500372 (CHEMBL3745943) Show SMILES CC(C)c1cc(NC(=O)n2ccc3cc(Oc4ncnc5CNCCc45)ccc23)n[nH]1 Show InChI InChI=1S/C22H23N7O2/c1-13(2)17-10-20(28-27-17)26-22(30)29-8-6-14-9-15(3-4-19(14)29)31-21-16-5-7-23-11-18(16)24-12-25-21/h3-4,6,8-10,12-13,23H,5,7,11H2,1-2H3,(H2,26,27,28,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of Tel-fused KDR (unknown origin) expressed in mouse BaF3 cells using poly(Glu,Tyr) as substrate after 10 mins by scintillation counting a...				J Med Chem 58: 9273-86 (2015) Article DOI: 10.1021/acs.jmedchem.5b01227 BindingDB Entry DOI: 10.7270/Q26M39T9
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50500372 (CHEMBL3745943) Show SMILES CC(C)c1cc(NC(=O)n2ccc3cc(Oc4ncnc5CNCCc45)ccc23)n[nH]1 Show InChI InChI=1S/C22H23N7O2/c1-13(2)17-10-20(28-27-17)26-22(30)29-8-6-14-9-15(3-4-19(14)29)31-21-16-5-7-23-11-18(16)24-12-25-21/h3-4,6,8-10,12-13,23H,5,7,11H2,1-2H3,(H2,26,27,28,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of KDR (unknown origin)				J Med Chem 58: 9273-86 (2015) Article DOI: 10.1021/acs.jmedchem.5b01227 BindingDB Entry DOI: 10.7270/Q26M39T9
					More data for this Ligand-Target Pair