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SMILES: Cc1nc(C)c(CNc2nc(CCCOc3ccccn3)nc(Cl)c2C)s1

InChI Key: InChIKey=VXECAYIGMKDKPM-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50500528   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A


(Homo sapiens (Human))		BDBM50500528
PNG
(CHEMBL3745991)
Show SMILES Cc1nc(C)c(CNc2nc(CCCOc3ccccn3)nc(Cl)c2C)s1
Show InChI InChI=1S/C19H22ClN5OS/c1-12-18(20)24-16(7-6-10-26-17-8-4-5-9-21-17)25-19(12)22-11-15-13(2)23-14(3)27-15/h4-5,8-9H,6-7,10-11H2,1-3H3,(H,22,24,25)
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 3.10n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of PDE10A (unknown origin) by IMAP assay

Bioorg Med Chem Lett 26: 126-32 (2016)


Article DOI: 10.1016/j.bmcl.2015.11.013
BindingDB Entry DOI: 10.7270/Q2NP27FW
More data for this
Ligand-Target Pair