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BDBM50502593 CHEMBL4578901

SMILES: CCc1nc(C)c(o1)C(=O)Nc1ccc(nc1)-c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1

InChI Key: InChIKey=RGZGIPKMQXYVRG-IYARVYRRSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50502593   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Diacylglycerol O-acyltransferase 1


(Mus musculus (mouse))		BDBM50502593
PNG
(CHEMBL4578901)
Show SMILES CCc1nc(C)c(o1)C(=O)Nc1ccc(nc1)-c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1 |r,wU:23.25,wD:26.29,(29.78,-24.78,;31.31,-24.62,;31.93,-23.21,;31.16,-21.88,;32.19,-20.73,;31.87,-19.23,;33.6,-21.35,;33.44,-22.89,;34.93,-20.58,;34.93,-19.04,;36.26,-21.34,;37.6,-20.57,;37.59,-19.04,;38.91,-18.26,;40.26,-19.03,;40.26,-20.57,;38.93,-21.34,;41.58,-18.25,;42.92,-19.02,;44.25,-18.25,;44.24,-16.71,;42.9,-15.94,;41.57,-16.72,;45.57,-15.93,;45.56,-14.4,;46.9,-13.62,;48.23,-14.39,;49.57,-13.62,;50.9,-14.39,;52.24,-13.62,;50.9,-15.93,;48.23,-15.93,;46.91,-16.7,)|
Show InChI InChI=1S/C26H29N3O4/c1-3-23-28-16(2)25(33-23)26(32)29-21-12-13-22(27-15-21)20-10-8-19(9-11-20)18-6-4-17(5-7-18)14-24(30)31/h8-13,15,17-18H,3-7,14H2,1-2H3,(H,29,32)(H,30,31)/t17-,18-
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PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 8n/an/an/an/a



Novartis Institutes for Biomedical Research

Curated by ChEMBL


Assay Description
Inhibition of DGAT1 in mouse C2C12 cells assessed as reduction in intracellular triglyceride production incubated for 2 hrs in presence of BSA-comple...

ACS Med Chem Lett 10: 1128-1133 (2019)


Article DOI: 10.1021/acsmedchemlett.9b00117
More data for this
Ligand-Target Pair