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SMILES: NC(=O)c1ccnc(NCc2ccc(cn2)-c2noc(n2)C(F)(F)F)c1

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 505045   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 6 (Homo sapiens (Human))	BDBM505045 (2-[({5-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-...) Show SMILES NC(=O)c1ccnc(NCc2ccc(cn2)-c2noc(n2)C(F)(F)F)c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DN485Z
					More data for this Ligand-Target Pair
Histone deacetylase 8 (Homo sapiens (Human))	BDBM505045 (2-[({5-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-...) Show SMILES NC(=O)c1ccnc(NCc2ccc(cn2)-c2noc(n2)C(F)(F)F)c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	750	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description HDAC8 reagents: HDAC8 was purchased from Enzo Life Sciences [catalog #BML-SE145]. Assays were performed with buffer containing 20 mM HEPES, pH 8.0 [B...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DN485Z
					More data for this Ligand-Target Pair
Histone deacetylase 1 (Homo sapiens (Human))	BDBM505045 (2-[({5-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-...) Show SMILES NC(=O)c1ccnc(NCc2ccc(cn2)-c2noc(n2)C(F)(F)F)c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DN485Z
					More data for this Ligand-Target Pair