BDBM50505268 CHEMBL4549009

SMILES: [H][C@]1(CN(Cc2cc(no2)-c2cc(C)c(cn2)C#N)C[C@H](C)N1)c1ccc2C(=O)OCc2c1C

InChI Key: InChIKey=QPPFGSDLXUMGKP-OWJWWREXSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50505268   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ATP-sensitive inward rectifier potassium channel 1 (Homo sapiens (Human))	BDBM50505268 (CHEMBL4549009) Show SMILES [H][C@]1(CN(Cc2cc(no2)-c2cc(C)c(cn2)C#N)C[C@H](C)N1)c1ccc2C(=O)OCc2c1C |r| Show InChI InChI=1S/C25H25N5O3/c1-14-6-22(27-9-17(14)8-26)23-7-18(33-29-23)11-30-10-15(2)28-24(12-30)19-4-5-20-21(16(19)3)13-32-25(20)31/h4-7,9,15,24,28H,10-13H2,1-3H3/t15-,24-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.60	n/a	n/a	n/a	n/a	n/a	n/a
University of Nebraska Medical Center Curated by ChEMBL					Assay Description Inhibition of human ROMK1 expressed in CHO cells by Tl+ flux assay				J Med Chem 62: 8682-8694 (2019) Article DOI: 10.1021/acs.jmedchem.8b01891
					More data for this Ligand-Target Pair