BDBM50505844 CHEMBL4444231

SMILES: CC(C)(O)Cn1c2ccccc2[nH]\c1=N/C(=O)c1cccc(c1)-c1cccnc1

InChI Key: InChIKey=MHBOZNIUOZGNHA-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50505844   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50505844 (CHEMBL4444231) Show SMILES CC(C)(O)Cn1c2ccccc2[nH]\c1=N/C(=O)c1cccc(c1)-c1cccnc1 Show InChI InChI=1S/C23H22N4O2/c1-23(2,29)15-27-20-11-4-3-10-19(20)25-22(27)26-21(28)17-8-5-7-16(13-17)18-9-6-12-24-14-18/h3-14,29H,15H2,1-2H3,(H,25,26,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim RCV GmbH & Co KG Curated by ChEMBL					Assay Description Inhibition of GST-fusion tagged EGFR L858R/T790M/C797S triple mutant (unknown origin) (696 to 1022 residues) expressed in insect cells assessed as de...				J Med Chem 62: 10272-10293 (2019) Article DOI: 10.1021/acs.jmedchem.9b01169
					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50505844 (CHEMBL4444231) Show SMILES CC(C)(O)Cn1c2ccccc2[nH]\c1=N/C(=O)c1cccc(c1)-c1cccnc1 Show InChI InChI=1S/C23H22N4O2/c1-23(2,29)15-27-20-11-4-3-10-19(20)25-22(27)26-21(28)17-8-5-7-16(13-17)18-9-6-12-24-14-18/h3-14,29H,15H2,1-2H3,(H,25,26,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim RCV GmbH & Co KG Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-tagged wild type EGFR expressed in baculovirus expression system assessed as decrease in phosphorylation of ULigh...				J Med Chem 62: 10272-10293 (2019) Article DOI: 10.1021/acs.jmedchem.9b01169
					More data for this Ligand-Target Pair