BDBM50505847 CHEMBL4476211

SMILES: COc1ccc2C(=O)N(C(=O)c2c1)c1ccccc1

InChI Key: InChIKey=MHLYJWUXEFWYLM-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50505847   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
NACHT, LRR and PYD domains-containing protein 3 (Mus musculus)	BDBM50505847 (CHEMBL4476211) Show SMILES COc1ccc2C(=O)N(C(=O)c2c1)c1ccccc1 Show InChI InChI=1S/C15H11NO3/c1-19-11-7-8-12-13(9-11)15(18)16(14(12)17)10-5-3-2-4-6-10/h2-9H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of NLRP3 inflammasome activation in LPS-primed mouse J774A.1 cells assessed as reduction in IL-1beta level preincubated for 1 hr followed ...				Eur J Med Chem 185: (2020) Article DOI: 10.1016/j.ejmech.2019.111822
					More data for this Ligand-Target Pair