Found 2 hits for monomerid = 50506019 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Apelin receptor
(Homo sapiens (Human)) | BDBM50506019
(CHEMBL4473347)Show SMILES CCC[C@@H](NC(=O)c1ccc(c(c1)C(O)=O)-c1c(Cl)cccc1-c1nc2cc(OC)ccc2[nH]1)c1ccccc1 |r,wD:3.37,(50.15,-45.98,;51.48,-45.21,;52.81,-45.98,;54.15,-45.21,;55.49,-45.97,;56.82,-45.2,;56.82,-43.66,;58.16,-45.97,;58.16,-47.52,;59.5,-48.28,;60.83,-47.51,;60.83,-45.97,;59.49,-45.2,;62.16,-45.2,;62.16,-43.66,;63.49,-45.97,;62.15,-48.28,;63.48,-47.51,;64.24,-46.17,;64.82,-48.28,;64.82,-49.83,;63.48,-50.6,;62.15,-49.83,;60.82,-50.6,;60.66,-52.13,;59.15,-52.45,;58.38,-53.78,;56.85,-53.78,;56.09,-55.11,;54.55,-55.11,;56.07,-52.44,;56.85,-51.12,;58.39,-51.12,;59.42,-49.98,;54.15,-43.67,;55.48,-42.9,;55.48,-41.36,;54.14,-40.59,;52.8,-41.37,;52.81,-42.9,)| Show InChI InChI=1S/C32H28ClN3O4/c1-3-8-26(19-9-5-4-6-10-19)36-31(37)20-13-15-22(24(17-20)32(38)39)29-23(11-7-12-25(29)33)30-34-27-16-14-21(40-2)18-28(27)35-30/h4-7,9-18,26H,3,8H2,1-2H3,(H,34,35)(H,36,37)(H,38,39)/t26-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.0620 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Agonist activity at human APJ-R expressed in HEK293 cells assessed as inhibition of forskolin- stimulated cAMP accumulation incubated for 30 mins by ... |
J Med Chem 62: 10456-10465 (2019)
Article DOI: 10.1021/acs.jmedchem.9b01513 |
More data for this
Ligand-Target Pair | |
Apelin receptor
(Rattus norvegicus) | BDBM50506019
(CHEMBL4473347)Show SMILES CCC[C@@H](NC(=O)c1ccc(c(c1)C(O)=O)-c1c(Cl)cccc1-c1nc2cc(OC)ccc2[nH]1)c1ccccc1 |r,wD:3.37,(50.15,-45.98,;51.48,-45.21,;52.81,-45.98,;54.15,-45.21,;55.49,-45.97,;56.82,-45.2,;56.82,-43.66,;58.16,-45.97,;58.16,-47.52,;59.5,-48.28,;60.83,-47.51,;60.83,-45.97,;59.49,-45.2,;62.16,-45.2,;62.16,-43.66,;63.49,-45.97,;62.15,-48.28,;63.48,-47.51,;64.24,-46.17,;64.82,-48.28,;64.82,-49.83,;63.48,-50.6,;62.15,-49.83,;60.82,-50.6,;60.66,-52.13,;59.15,-52.45,;58.38,-53.78,;56.85,-53.78,;56.09,-55.11,;54.55,-55.11,;56.07,-52.44,;56.85,-51.12,;58.39,-51.12,;59.42,-49.98,;54.15,-43.67,;55.48,-42.9,;55.48,-41.36,;54.14,-40.59,;52.8,-41.37,;52.81,-42.9,)| Show InChI InChI=1S/C32H28ClN3O4/c1-3-8-26(19-9-5-4-6-10-19)36-31(37)20-13-15-22(24(17-20)32(38)39)29-23(11-7-12-25(29)33)30-34-27-16-14-21(40-2)18-28(27)35-30/h4-7,9-18,26H,3,8H2,1-2H3,(H,34,35)(H,36,37)(H,38,39)/t26-/m1/s1 | UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 0.120 | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb
Curated by ChEMBL
| Assay Description
Agonist activity at rat APJ-R expressed in HEK293 cells assessed as inhibition of forskolin- stimulated cAMP accumulation incubated for 30 mins by HT... |
J Med Chem 62: 10456-10465 (2019)
Article DOI: 10.1021/acs.jmedchem.9b01513 |
More data for this
Ligand-Target Pair | |
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