BDBM50506737 CHEMBL4555254

SMILES: CC(C)Cn1c(=O)[nH]c(C(=O)N[C@H]2CC[C@H](CC2)c2ccccc2)c(O)c1=O

InChI Key: InChIKey=VBKQYPZEJLYVPT-IYBDPMFKSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50506737   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Endothelial lipase (Homo sapiens (Human))	BDBM50506737 (CHEMBL4555254) Show SMILES CC(C)Cn1c(=O)[nH]c(C(=O)N[C@H]2CC[C@H](CC2)c2ccccc2)c(O)c1=O |r,wU:12.11,15.18,(50.18,-52.33,;48.85,-51.57,;47.52,-52.33,;48.85,-50.03,;47.52,-49.27,;46.18,-50.04,;46.18,-51.58,;44.85,-49.27,;44.85,-47.73,;43.51,-46.97,;43.5,-45.43,;42.18,-47.74,;40.84,-46.98,;39.52,-47.75,;38.18,-46.98,;38.18,-45.44,;39.51,-44.67,;40.84,-45.44,;36.84,-44.67,;36.85,-43.13,;35.51,-42.36,;34.18,-43.13,;34.18,-44.68,;35.52,-45.44,;46.18,-46.95,;46.17,-45.41,;47.51,-47.72,;48.85,-46.96,)| Show InChI InChI=1S/C21H27N3O4/c1-13(2)12-24-20(27)18(25)17(23-21(24)28)19(26)22-16-10-8-15(9-11-16)14-6-4-3-5-7-14/h3-7,13,15-16,25H,8-12H2,1-2H3,(H,22,26)(H,23,28)/t15-,16+	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of endothelial lipase (unknown origin) using D31-POPC-HDL as substrate after 2 hrs in presence of human serum by LC/MS analysis				Bioorg Med Chem Lett 28: 3721-3725 (2018) Article DOI: 10.1016/j.bmcl.2018.10.022
					More data for this Ligand-Target Pair
Endothelial lipase (Homo sapiens (Human))	BDBM50506737 (CHEMBL4555254) Show SMILES CC(C)Cn1c(=O)[nH]c(C(=O)N[C@H]2CC[C@H](CC2)c2ccccc2)c(O)c1=O |r,wU:12.11,15.18,(50.18,-52.33,;48.85,-51.57,;47.52,-52.33,;48.85,-50.03,;47.52,-49.27,;46.18,-50.04,;46.18,-51.58,;44.85,-49.27,;44.85,-47.73,;43.51,-46.97,;43.5,-45.43,;42.18,-47.74,;40.84,-46.98,;39.52,-47.75,;38.18,-46.98,;38.18,-45.44,;39.51,-44.67,;40.84,-45.44,;36.84,-44.67,;36.85,-43.13,;35.51,-42.36,;34.18,-43.13,;34.18,-44.68,;35.52,-45.44,;46.18,-46.95,;46.17,-45.41,;47.51,-47.72,;48.85,-46.96,)| Show InChI InChI=1S/C21H27N3O4/c1-13(2)12-24-20(27)18(25)17(23-21(24)28)19(26)22-16-10-8-15(9-11-16)14-6-4-3-5-7-14/h3-7,13,15-16,25H,8-12H2,1-2H3,(H,22,26)(H,23,28)/t15-,16+	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	59	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Curated by ChEMBL					Assay Description Inhibition of recombinant human endothelial lipase expressed in African green monkey COS7 cells using HDL as substrate pretreated for 10 mins followe...				Bioorg Med Chem Lett 28: 3721-3725 (2018) Article DOI: 10.1016/j.bmcl.2018.10.022
					More data for this Ligand-Target Pair