BDBM50507408 CHEMBL4561977
SMILES: OC(=O)CNC(=O)c1c(O)c2COCc2n(Cc2ccc(OC(F)(F)F)cc2)c1=O
InChI Key: InChIKey=BDPOWDVIVMVEAP-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Prolyl hydroxylase EGLN3 (Homo sapiens (Human)) | BDBM50507408![]() (CHEMBL4561977) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co., Inc. Curated by ChEMBL | Assay Description Inhibition of recombinant human HIF-PHD3 expressed in baculovirus-infected Sf9 cells using biotin labelled DLDLEMLAPYIPMDDDFQL and 2-oxoglutarate as ... | ACS Med Chem Lett 9: 1193-1198 (2018) Article DOI: 10.1021/acsmedchemlett.8b00274 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Egl nine homolog 1 (Homo sapiens (Human)) | BDBM50507408![]() (CHEMBL4561977) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co., Inc. Curated by ChEMBL | Assay Description Inhibition of recombinant human HIF-PHD2 expressed in baculovirus-infected Sf9 cells using biotin labelled DLDLEMLAPYIPMDDDFQL and 2-oxoglutarate as ... | ACS Med Chem Lett 9: 1193-1198 (2018) Article DOI: 10.1021/acsmedchemlett.8b00274 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hypoxia-inducible factor prolyl hydroxylase (Homo sapiens (Human)) | BDBM50507408![]() (CHEMBL4561977) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co., Inc. Curated by ChEMBL | Assay Description Inhibition of recombinant human HIF-PHD1 expressed in baculovirus-infected Sf9 cells using biotin labelled DLDLEMLAPYIPMDDDFQL and 2-oxoglutarate as ... | ACS Med Chem Lett 9: 1193-1198 (2018) Article DOI: 10.1021/acsmedchemlett.8b00274 | |||||||||||
More data for this Ligand-Target Pair |