BDBM50508015 CHEMBL4470337

SMILES: Cc1cccc2c(ncnc12)C1CCN(CC1)C(=O)c1ccc(OC(F)(F)F)cc1

InChI Key: InChIKey=ALRANRPSROSEJQ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50508015   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Extracellular signal-regulated kinase 5 (ERK5) (Homo sapiens (Human))	BDBM50508015 (CHEMBL4470337) Show SMILES Cc1cccc2c(ncnc12)C1CCN(CC1)C(=O)c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C22H20F3N3O2/c1-14-3-2-4-18-19(14)26-13-27-20(18)15-9-11-28(12-10-15)21(29)16-5-7-17(8-6-16)30-22(23,24)25/h2-8,13,15H,9-12H2,1H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Bayer AG Curated by ChEMBL					Assay Description Inhibition of His-tagged MAP2K5 activated N-terminal GST-tagged recombinant human ERK5 (1 to 398 residues) expressed in Escherichia coli using biotin...				J Med Chem 62: 928-940 (2019) Article DOI: 10.1021/acs.jmedchem.8b01606
					More data for this Ligand-Target Pair