BDBM50508589 CHEMBL4466246
SMILES: Nc1c(sc(NCC=C)c1C#N)C(=O)c1ccc(Cl)s1
InChI Key: InChIKey=HYZRUYIVRFEMQJ-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Maternal embryonic leucine zipper kinase (Homo sapiens (Human)) | BDBM50508589![]() (CHEMBL4466246) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 638 | n/a | n/a | n/a | n/a | n/a | n/a |
Selvita S.A Curated by ChEMBL | Assay Description Inhibition of recombinant human MELK expressed in Escherichia coli using ZIPtide as substrate measured after 0.5 hrs by ADP-Glo assay | Bioorg Med Chem Lett 29: 607-613 (2019) Article DOI: 10.1016/j.bmcl.2018.12.051 | |||||||||||
More data for this Ligand-Target Pair |