BDBM50509149 CHEMBL3421836

SMILES: C[C@@H]1N([C@@H](CO)Cc2c(CC(C)(C)O)cccc12)C(=O)Cc1c(Cl)cccc1Cl

InChI Key: InChIKey=QBKZBAUOKUPKIJ-GOEBONIOSA-N

Data: 2 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50509149   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50509149 (CHEMBL3421836) Show SMILES C[C@@H]1N([C@@H](CO)Cc2c(CC(C)(C)O)cccc12)C(=O)Cc1c(Cl)cccc1Cl |r| Show InChI InChI=1S/C23H27Cl2NO3/c1-14-17-7-4-6-15(12-23(2,3)29)18(17)10-16(13-27)26(14)22(28)11-19-20(24)8-5-9-21(19)25/h4-9,14,16,27,29H,10-13H2,1-3H3/t14-,16+/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	76	n/a	n/a	n/a	n/a
AMRI UK Ltd Curated by ChEMBL					Assay Description Positive allosteric modulator activity at human D1 receptor stably expressed in HEK293 cells assessed as potentiation of EC20 dopamine-induced cAMP a...				J Med Chem 62: 8711-8732 (2019) Article DOI: 10.1021/acs.jmedchem.9b01234
					More data for this Ligand-Target Pair
D(1A) dopamine receptor (Homo sapiens (Human))	BDBM50509149 (CHEMBL3421836) Show SMILES C[C@@H]1N([C@@H](CO)Cc2c(CC(C)(C)O)cccc12)C(=O)Cc1c(Cl)cccc1Cl |r| Show InChI InChI=1S/C23H27Cl2NO3/c1-14-17-7-4-6-15(12-23(2,3)29)18(17)10-16(13-27)26(14)22(28)11-19-20(24)8-5-9-21(19)25/h4-9,14,16,27,29H,10-13H2,1-3H3/t14-,16+/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3.70	n/a	n/a	n/a	n/a
UCB Pharma Curated by ChEMBL					Assay Description Positive allosteric modulation of human D1R expressed in HEK293 cells assessed as increase in dopamine-induced cAMP accumulation after 60 mins by HTR...				J Med Chem 62: 128-140 (2019) Article DOI: 10.1021/acs.jmedchem.8b01767
					More data for this Ligand-Target Pair