BDBM50511621 CHEMBL4457356

SMILES: Cc1nc(C)c(s1)-c1ncc(Cl)c(Nc2ccc3n(C)c(=O)n(CCC(C)(C)O)c3c2)n1

InChI Key: InChIKey=NDZZEROMSRMWNH-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50511621   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
BCoR-BCL6 (Homo sapiens)	BDBM50511621 (CHEMBL4457356) Show SMILES Cc1nc(C)c(s1)-c1ncc(Cl)c(Nc2ccc3n(C)c(=O)n(CCC(C)(C)O)c3c2)n1 Show InChI InChI=1S/C22H25ClN6O2S/c1-12-18(32-13(2)25-12)20-24-11-15(23)19(27-20)26-14-6-7-16-17(10-14)29(21(30)28(16)5)9-8-22(3,4)31/h6-7,10-11,31H,8-9H2,1-5H3,(H,24,26,27)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of recombinant His-tagged human BCL6 expressed in Escherichia coli BL21 AI cell incubated for 2 hrs by TR-FRET assay				J Med Chem 63: 4047-4068 (2020) Article DOI: 10.1021/acs.jmedchem.9b02076
					More data for this Ligand-Target Pair