BDBM50514510 CHEMBL4442889

SMILES: CN1CCN(CC1)c1ccc(Nc2ncc(c(Nc3ccccc3NC(=O)C=C)n2)-c2ccc(Oc3ccccc3)cc2)cc1

InChI Key: InChIKey=DRVQAPPKJMZKCF-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50514510   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calmodulin/Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50514510 (CHEMBL4442889) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(c(Nc3ccccc3NC(=O)C=C)n2)-c2ccc(Oc3ccccc3)cc2)cc1 Show InChI InChI=1S/C36H35N7O2/c1-3-34(44)39-32-11-7-8-12-33(32)40-35-31(26-13-19-30(20-14-26)45-29-9-5-4-6-10-29)25-37-36(41-35)38-27-15-17-28(18-16-27)43-23-21-42(2)22-24-43/h3-20,25H,1,21-24H2,2H3,(H,39,44)(H2,37,38,40,41)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of recombinant human His-tagged full length SRC expressed in baculovirus expression system using tyrosine-2 peptide as substrate incubated...				J Med Chem 63: 1624-1641 (2020) Article DOI: 10.1021/acs.jmedchem.9b01502
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 (Homo sapiens (Human))	BDBM50514510 (CHEMBL4442889) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(c(Nc3ccccc3NC(=O)C=C)n2)-c2ccc(Oc3ccccc3)cc2)cc1 Show InChI InChI=1S/C36H35N7O2/c1-3-34(44)39-32-11-7-8-12-33(32)40-35-31(26-13-19-30(20-14-26)45-29-9-5-4-6-10-29)25-37-36(41-35)38-27-15-17-28(18-16-27)43-23-21-42(2)22-24-43/h3-20,25H,1,21-24H2,2H3,(H,39,44)(H2,37,38,40,41)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.46E+3	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of tracer 222 binding to recombinant human His-tagged TAK1 (437 to 504 residues) expressed in baculovirus expression system using tyrosine...				J Med Chem 63: 1624-1641 (2020) Article DOI: 10.1021/acs.jmedchem.9b01502
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM50514510 (CHEMBL4442889) Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc(c(Nc3ccccc3NC(=O)C=C)n2)-c2ccc(Oc3ccccc3)cc2)cc1 Show InChI InChI=1S/C36H35N7O2/c1-3-34(44)39-32-11-7-8-12-33(32)40-35-31(26-13-19-30(20-14-26)45-29-9-5-4-6-10-29)25-37-36(41-35)38-27-15-17-28(18-16-27)43-23-21-42(2)22-24-43/h3-20,25H,1,21-24H2,2H3,(H,39,44)(H2,37,38,40,41)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	89	n/a	n/a	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of recombinant human His-tagged FGFR1 (308 to 731 residues) expressed in baculovirus expression system using tyrosine-4 peptide as substra...				J Med Chem 63: 1624-1641 (2020) Article DOI: 10.1021/acs.jmedchem.9b01502
					More data for this Ligand-Target Pair