BDBM50514660 DCFPYL::Dcfpyl::US10894807, ID P002
SMILES: OC(=O)CC[C@H](NC(=O)N[C@@H](CCCCNC(=O)c1ccc(F)nc1)C(O)=O)C(O)=O
InChI Key: InChIKey=OLWVRJUNLXQDSP-RYUDHWBXSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Glutamate carboxypeptidase II (Homo sapiens (Human)) | BDBM50514660 (DCFPYL | Dcfpyl | US10894807, ID P002) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 15.6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Siemens Medical Solutions USA, Inc. US Patent | Assay Description The inhibitory activity of all compounds was determined using a fluorescent assay of human PSMA activity. The enzyme used in the assay was purchased ... | US Patent US10894807 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Glutamate carboxypeptidase II (Homo sapiens (Human)) | BDBM50514660 (DCFPYL | Dcfpyl | US10894807, ID P002) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea University Curated by ChEMBL | Assay Description Inhibition of PSMA in human LNCaP cell extracts in presence of N-acetylaspartylglutamate by Amplex red glutamic acid dependent fluorescence-based NAA... | J Med Chem 63: 3261-3273 (2020) Article DOI: 10.1021/acs.jmedchem.9b02022 | |||||||||||
More data for this Ligand-Target Pair |