BDBM50517633 CHEMBL4471150

SMILES: CC(C)[C@H](NC(=O)[C@H](Cc1ccc(CN)cc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](CCC1CCCCC1)C(=O)[C@@]1(C)CO1

InChI Key: InChIKey=KBHBYJJWABADGJ-ICQXYBJGSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50517633   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
20S proteasome (Homo sapiens (Human))	BDBM50517633 (CHEMBL4471150) Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccc(CN)cc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](CCC1CCCCC1)C(=O)[C@@]1(C)CO1 |r| Show InChI InChI=1S/C37H51N7O5/c1-24(2)32(36(48)40-29(33(45)37(3)23-49-37)19-18-25-10-6-4-7-11-25)42-34(46)30(20-27-14-16-28(22-38)17-15-27)41-35(47)31(43-44-39)21-26-12-8-5-9-13-26/h5,8-9,12-17,24-25,29-32H,4,6-7,10-11,18-23,38H2,1-3H3,(H,40,48)(H,41,47)(H,42,46)/t29-,30-,31-,32-,37+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Leiden Institute of Chemistry and Netherlands Proteomics Centre Curated by ChEMBL					Assay Description Inhibition of 20S constitutive proteasome beta 2 trypsin-like activity (unknown origin) by cell based ABPP assay				J Med Chem 62: 1626-1642 (2019) Article DOI: 10.1021/acs.jmedchem.8b01884
					More data for this Ligand-Target Pair
Proteasome subunit beta type-10 (Homo sapiens (Human))	BDBM50517633 (CHEMBL4471150) Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccc(CN)cc1)NC(=O)[C@H](Cc1ccccc1)N=[N+]=[N-])C(=O)N[C@@H](CCC1CCCCC1)C(=O)[C@@]1(C)CO1 |r| Show InChI InChI=1S/C37H51N7O5/c1-24(2)32(36(48)40-29(33(45)37(3)23-49-37)19-18-25-10-6-4-7-11-25)42-34(46)30(20-27-14-16-28(22-38)17-15-27)41-35(47)31(43-44-39)21-26-12-8-5-9-13-26/h5,8-9,12-17,24-25,29-32H,4,6-7,10-11,18-23,38H2,1-3H3,(H,40,48)(H,41,47)(H,42,46)/t29-,30-,31-,32-,37+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	39	n/a	n/a	n/a	n/a	n/a	n/a
Leiden Institute of Chemistry and Netherlands Proteomics Centre Curated by ChEMBL					Assay Description Inhibition of 20S immunoproteasome beta 2 (unknown origin) by cell based ABPP assay				J Med Chem 62: 1626-1642 (2019) Article DOI: 10.1021/acs.jmedchem.8b01884
					More data for this Ligand-Target Pair