BindingDB logo
myBDB logout

null

SMILES: CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn(CC#N)c3ncnc(N)c23)no1

InChI Key: InChIKey=AMIXSBFSWJBUFS-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50521489   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM50521489
PNG
(CHEMBL4440175)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn(CC#N)c3ncnc(N)c23)no1
Show InChI InChI=1S/C22H22N8O2/c1-22(2,3)16-10-17(29-32-16)28-21(31)27-14-6-4-13(5-7-14)15-11-30(9-8-23)20-18(15)19(24)25-12-26-20/h4-7,10-12H,9H2,1-3H3,(H2,24,25,26)(H2,27,28,29,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 9n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of recombinant human FLT3 (564 to end residues) using EAIYAAPFAKKK as substrate measured after 40 mins in presence of [gamma-33P]-ATP by s...

J Med Chem 62: 4158-4173 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00223
More data for this
Ligand-Target Pair