BDBM50521496 CHEMBL4435457

SMILES: CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn(CCC#N)c3ncnc(N)c23)no1

InChI Key: InChIKey=YWNGZCYLQFXXHD-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50521496   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50521496 (CHEMBL4435457) Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn(CCC#N)c3ncnc(N)c23)no1 Show InChI InChI=1S/C23H24N8O2/c1-23(2,3)17-11-18(30-33-17)29-22(32)28-15-7-5-14(6-8-15)16-12-31(10-4-9-24)21-19(16)20(25)26-13-27-21/h5-8,11-13H,4,10H2,1-3H3,(H2,25,26,27)(H2,28,29,30,32)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of recombinant human FLT3 (564 to end residues) using EAIYAAPFAKKK as substrate measured after 40 mins in presence of [gamma-33P]-ATP by s...				J Med Chem 62: 4158-4173 (2019) Article DOI: 10.1021/acs.jmedchem.9b00223
					More data for this Ligand-Target Pair