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BDBM50528412 CHEMBL4529738

SMILES: Cn1ncc(Cl)c1-c1coc(c1)C(=O)N[C@@H]1CNCC[C@H]1c1ccc(F)c(F)c1

InChI Key: InChIKey=XHJRBDCMLYCIII-SUMWQHHRSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50528412   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
RAC-alpha serine/threonine-protein kinase


(Homo sapiens (Human))		BDBM50528412
PNG
(CHEMBL4529738)
Show SMILES Cn1ncc(Cl)c1-c1coc(c1)C(=O)N[C@@H]1CNCC[C@H]1c1ccc(F)c(F)c1 |r|
Show InChI InChI=1S/C20H19ClF2N4O2/c1-27-19(14(21)8-25-27)12-7-18(29-10-12)20(28)26-17-9-24-5-4-13(17)11-2-3-15(22)16(23)6-11/h2-3,6-8,10,13,17,24H,4-5,9H2,1H3,(H,26,28)/t13-,17+/m0/s1
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5.10n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human Akt1 expressed in Escherichia coli using STK Substrate 2-biotin as substrate incubated for 1 hr by HTRF assay

J Med Chem 62: 7264-7288 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00891
More data for this
Ligand-Target Pair