BindingDB PrimarySearch

BDBM50531540 CHEBI:75998::GSK-1120212::GSK1120212::JTP 74057::JTP-74057::Mekinist::TMT-212::TMT212::TRAMETINIB::Tmt212::Trametinib

SMILES: CC(=O)Nc1cccc(c1)-n1c2c(C)c(=O)n(C)c(Nc3ccc(I)cc3F)c2c(=O)n(C2CC2)c1=O

InChI Key: InChIKey=LIRYPHYGHXZJBZ-UHFFFAOYSA-N

Data: 2 IC50 1 EC50

PDB links: 3 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50531540
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Multidrug resistance protein 1/Multidrug resistance associated protein 1 (Homo sapiens (Human))	BDBM50531540 (CHEBI:75998 \| GSK-1120212 \| GSK1120212 \| JTP 74057...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	n/a	n/a	247	n/a	n/a	n/a	n/a
Rheinische Friedrich-Wilhelms-University of Bonn Curated by ChEMBL					Assay Description Inhibition of ABCB1 in human A2780/ADR cells assessed as potentiation of daunorubicin-induced cytotoxicity measured after 72 hrs by MTT assay				Eur J Med Chem 164: 193-213 (2019) Article DOI: 10.1016/j.ejmech.2018.12.019
					More data for this Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1/Mitogen-activated protein kinase 1/RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50531540 (CHEBI:75998 \| GSK-1120212 \| GSK1120212 \| JTP 74057...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
Mansoura University Curated by ChEMBL					Assay Description Inhibition of MEK1 (unknown origin)				Eur J Med Chem 168: 315-329 (2019) Article DOI: 10.1016/j.ejmech.2019.02.050
Mansoura University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Dual specificity mitogen-activated protein kinase kinase; MEK1/2 (Homo sapiens (Human))	BDBM50531540 (CHEBI:75998 \| GSK-1120212 \| GSK1120212 \| JTP 74057...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
VHL-MAP2K1/MAP2K2 (Homo sapiens (Human))	BDBM50531540 (CHEBI:75998 \| GSK-1120212 \| GSK1120212 \| JTP 74057...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB	n/a	n/a	2.16	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Dual specificity mitogen-activated protein kinase kinase; MEK1/2 (Homo sapiens (Human))	BDBM50531540 (CHEBI:75998 \| GSK-1120212 \| GSK1120212 \| JTP 74057...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Mansoura University Curated by ChEMBL					Assay Description Inhibition of MEK2 (unknown origin)				Eur J Med Chem 168: 315-329 (2019) Article DOI: 10.1016/j.ejmech.2019.02.050
Mansoura University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)