null

SMILES: CCc1cccc(N2CCN(CC(O)CCNC(=O)c3cc4ccccc4o3)CC2)c1Cl

InChI Key: InChIKey=ANDAVALYLUYQOC-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50533619   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50533619 (CHEMBL4517102) Show SMILES CCc1cccc(N2CCN(CC(O)CCNC(=O)c3cc4ccccc4o3)CC2)c1Cl Show InChI InChI=1S/C25H30ClN3O3/c1-2-18-7-5-8-21(24(18)26)29-14-12-28(13-15-29)17-20(30)10-11-27-25(31)23-16-19-6-3-4-9-22(19)32-23/h3-9,16,20,30H,2,10-15,17H2,1H3,(H,27,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.985	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL					Assay Description Displacement of [3H]N-methylspiperone from human dopamine D3 receptor expressed in HEK293 cell membranes incubated for 1 hr by liquid scintillation c...				J Med Chem 59: 7634-50 (2016) Article DOI: 10.1021/acs.jmedchem.6b00860
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50533619 (CHEMBL4517102) Show SMILES CCc1cccc(N2CCN(CC(O)CCNC(=O)c3cc4ccccc4o3)CC2)c1Cl Show InChI InChI=1S/C25H30ClN3O3/c1-2-18-7-5-8-21(24(18)26)29-14-12-28(13-15-29)17-20(30)10-11-27-25(31)23-16-19-6-3-4-9-22(19)32-23/h3-9,16,20,30H,2,10-15,17H2,1H3,(H,27,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	3.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL					Assay Description Displacement of [125I]DOI from 5-HT2A receptor (unknown origin)				J Med Chem 59: 7634-50 (2016) Article DOI: 10.1021/acs.jmedchem.6b00860
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50533619 (CHEMBL4517102) Show SMILES CCc1cccc(N2CCN(CC(O)CCNC(=O)c3cc4ccccc4o3)CC2)c1Cl Show InChI InChI=1S/C25H30ClN3O3/c1-2-18-7-5-8-21(24(18)26)29-14-12-28(13-15-29)17-20(30)10-11-27-25(31)23-16-19-6-3-4-9-22(19)32-23/h3-9,16,20,30H,2,10-15,17H2,1H3,(H,27,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	28	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL					Assay Description Displacement of [3H]-8-OH-DPAT from 5-HT1A receptor (unknown origin)				J Med Chem 59: 7634-50 (2016) Article DOI: 10.1021/acs.jmedchem.6b00860
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50533619 (CHEMBL4517102) Show SMILES CCc1cccc(N2CCN(CC(O)CCNC(=O)c3cc4ccccc4o3)CC2)c1Cl Show InChI InChI=1S/C25H30ClN3O3/c1-2-18-7-5-8-21(24(18)26)29-14-12-28(13-15-29)17-20(30)10-11-27-25(31)23-16-19-6-3-4-9-22(19)32-23/h3-9,16,20,30H,2,10-15,17H2,1H3,(H,27,31)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	89	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL					Assay Description Displacement of [125I]DOI from 5-HT2C receptor (unknown origin)				J Med Chem 59: 7634-50 (2016) Article DOI: 10.1021/acs.jmedchem.6b00860
					More data for this Ligand-Target Pair
D(2) dopamine receptor (Homo sapiens (Human))	BDBM50533619 (CHEMBL4517102) Show SMILES CCc1cccc(N2CCN(CC(O)CCNC(=O)c3cc4ccccc4o3)CC2)c1Cl Show InChI InChI=1S/C25H30ClN3O3/c1-2-18-7-5-8-21(24(18)26)29-14-12-28(13-15-29)17-20(30)10-11-27-25(31)23-16-19-6-3-4-9-22(19)32-23/h3-9,16,20,30H,2,10-15,17H2,1H3,(H,27,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	164	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL					Assay Description Displacement of [3H]N-methylspiperone from human dopamine D2L receptor expressed in HEK293 cell membranes incubated for 1 hr by liquid scintillation ...				J Med Chem 59: 7634-50 (2016) Article DOI: 10.1021/acs.jmedchem.6b00860
					More data for this Ligand-Target Pair
D(4) dopamine receptor (Homo sapiens (Human))	BDBM50533619 (CHEMBL4517102) Show SMILES CCc1cccc(N2CCN(CC(O)CCNC(=O)c3cc4ccccc4o3)CC2)c1Cl Show InChI InChI=1S/C25H30ClN3O3/c1-2-18-7-5-8-21(24(18)26)29-14-12-28(13-15-29)17-20(30)10-11-27-25(31)23-16-19-6-3-4-9-22(19)32-23/h3-9,16,20,30H,2,10-15,17H2,1H3,(H,27,31)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	2.38E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL					Assay Description Displacement of [3H]N-methylspiperone from human dopamine D4.4 receptor expressed in HEK293 cell membranes incubated for 1 hr by liquid scintillation...				J Med Chem 59: 7634-50 (2016) Article DOI: 10.1021/acs.jmedchem.6b00860
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50533619 (CHEMBL4517102) Show SMILES CCc1cccc(N2CCN(CC(O)CCNC(=O)c3cc4ccccc4o3)CC2)c1Cl Show InChI InChI=1S/C25H30ClN3O3/c1-2-18-7-5-8-21(24(18)26)29-14-12-28(13-15-29)17-20(30)10-11-27-25(31)23-16-19-6-3-4-9-22(19)32-23/h3-9,16,20,30H,2,10-15,17H2,1H3,(H,27,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL					Assay Description Antagonist activity at human dopamine D3 receptor expressed in CHO cells assessed as inhibition of quinpirole-stimulated mitogenesis incubated for 16...				J Med Chem 59: 7634-50 (2016) Article DOI: 10.1021/acs.jmedchem.6b00860
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50533619 (CHEMBL4517102) Show SMILES CCc1cccc(N2CCN(CC(O)CCNC(=O)c3cc4ccccc4o3)CC2)c1Cl Show InChI InChI=1S/C25H30ClN3O3/c1-2-18-7-5-8-21(24(18)26)29-14-12-28(13-15-29)17-20(30)10-11-27-25(31)23-16-19-6-3-4-9-22(19)32-23/h3-9,16,20,30H,2,10-15,17H2,1H3,(H,27,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	196	n/a	n/a	n/a	n/a
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL					Assay Description Agonist activity at human dopamine D3 receptor expressed in CHO cells assessed as stimulation of mitogenesis incubated for 16 hrs in presence of [3H]...				J Med Chem 59: 7634-50 (2016) Article DOI: 10.1021/acs.jmedchem.6b00860
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Homo sapiens (Human))	BDBM50533619 (CHEMBL4517102) Show SMILES CCc1cccc(N2CCN(CC(O)CCNC(=O)c3cc4ccccc4o3)CC2)c1Cl Show InChI InChI=1S/C25H30ClN3O3/c1-2-18-7-5-8-21(24(18)26)29-14-12-28(13-15-29)17-20(30)10-11-27-25(31)23-16-19-6-3-4-9-22(19)32-23/h3-9,16,20,30H,2,10-15,17H2,1H3,(H,27,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	118	n/a	n/a	n/a	n/a
National Institute on Drug Abuse-Intramural Research Program Curated by ChEMBL					Assay Description Agonist activity at 5-HT1A receptor (unknown origin) by [35S]GTPgammaS binding assay				J Med Chem 59: 7634-50 (2016) Article DOI: 10.1021/acs.jmedchem.6b00860
					More data for this Ligand-Target Pair