BDBM50534300 CHEMBL4442125

SMILES: Fc1ccc(COc2cccc(c2)-c2cn(nn2)[C@@H]2CN3CCC2CC3)cc1

InChI Key: InChIKey=KBCGDBMDBJDDGG-JOCHJYFZSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50534300   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Neuronal acetylcholine receptor; alpha3/beta4 (Homo sapiens (Human))	BDBM50534300 (CHEMBL4442125) Show SMILES Fc1ccc(COc2cccc(c2)-c2cn(nn2)[C@@H]2CN3CCC2CC3)cc1 |r,wD:18.19,THB:15:18:21.22:25.24,(49.35,-52.09,;48.58,-50.75,;47.04,-50.75,;46.28,-49.41,;47.06,-48.08,;46.29,-46.74,;44.75,-46.74,;43.99,-45.4,;44.77,-44.06,;43.99,-42.72,;42.46,-42.72,;41.69,-44.05,;42.45,-45.39,;40.15,-44.05,;39.1,-45.18,;37.7,-44.53,;37.89,-43,;39.4,-42.7,;36.36,-45.28,;36.15,-46.67,;34.62,-46.01,;33.25,-46.64,;33.54,-45.24,;34.88,-44.64,;34.82,-43,;34.36,-44.11,;48.59,-48.08,;49.36,-49.41,)| Show InChI InChI=1S/C22H23FN4O/c23-19-6-4-16(5-7-19)15-28-20-3-1-2-18(12-20)21-13-27(25-24-21)22-14-26-10-8-17(22)9-11-26/h1-7,12-13,17,22H,8-11,14-15H2/t22-/m1/s1	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	7.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Mahidol University Curated by ChEMBL					Assay Description Displacement of [3H]epibatidine from human alpha3beta4 nAChR transfected in HEK293 cell membranes after 120 mins by liquid scintillation counting				ACS Med Chem Lett 7: 890-895 (2016) Article DOI: 10.1021/acsmedchemlett.6b00146
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-7 subunit (Homo sapiens (Human))	BDBM50534300 (CHEMBL4442125) Show SMILES Fc1ccc(COc2cccc(c2)-c2cn(nn2)[C@@H]2CN3CCC2CC3)cc1 |r,wD:18.19,THB:15:18:21.22:25.24,(49.35,-52.09,;48.58,-50.75,;47.04,-50.75,;46.28,-49.41,;47.06,-48.08,;46.29,-46.74,;44.75,-46.74,;43.99,-45.4,;44.77,-44.06,;43.99,-42.72,;42.46,-42.72,;41.69,-44.05,;42.45,-45.39,;40.15,-44.05,;39.1,-45.18,;37.7,-44.53,;37.89,-43,;39.4,-42.7,;36.36,-45.28,;36.15,-46.67,;34.62,-46.01,;33.25,-46.64,;33.54,-45.24,;34.88,-44.64,;34.82,-43,;34.36,-44.11,;48.59,-48.08,;49.36,-49.41,)| Show InChI InChI=1S/C22H23FN4O/c23-19-6-4-16(5-7-19)15-28-20-3-1-2-18(12-20)21-13-27(25-24-21)22-14-26-10-8-17(22)9-11-26/h1-7,12-13,17,22H,8-11,14-15H2/t22-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	149	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Mahidol University Curated by ChEMBL					Assay Description Displacement of [3H]MLA from human alpha7 nAChR transfected in human SH-SY5Y cell membranes after 120 mins by liquid scintillation counting				ACS Med Chem Lett 7: 890-895 (2016) Article DOI: 10.1021/acsmedchemlett.6b00146
					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor Alpha-4/Beta-2 (Homo sapiens (Human))	BDBM50534300 (CHEMBL4442125) Show SMILES Fc1ccc(COc2cccc(c2)-c2cn(nn2)[C@@H]2CN3CCC2CC3)cc1 |r,wD:18.19,THB:15:18:21.22:25.24,(49.35,-52.09,;48.58,-50.75,;47.04,-50.75,;46.28,-49.41,;47.06,-48.08,;46.29,-46.74,;44.75,-46.74,;43.99,-45.4,;44.77,-44.06,;43.99,-42.72,;42.46,-42.72,;41.69,-44.05,;42.45,-45.39,;40.15,-44.05,;39.1,-45.18,;37.7,-44.53,;37.89,-43,;39.4,-42.7,;36.36,-45.28,;36.15,-46.67,;34.62,-46.01,;33.25,-46.64,;33.54,-45.24,;34.88,-44.64,;34.82,-43,;34.36,-44.11,;48.59,-48.08,;49.36,-49.41,)| Show InChI InChI=1S/C22H23FN4O/c23-19-6-4-16(5-7-19)15-28-20-3-1-2-18(12-20)21-13-27(25-24-21)22-14-26-10-8-17(22)9-11-26/h1-7,12-13,17,22H,8-11,14-15H2/t22-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	537	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Mahidol University Curated by ChEMBL					Assay Description Displacement of [3H]epibatidine from human alpha4beta2 nAChR transfected in HEK293 cell membranes after 120 mins by liquid scintillation counting				ACS Med Chem Lett 7: 890-895 (2016) Article DOI: 10.1021/acsmedchemlett.6b00146
					More data for this Ligand-Target Pair