null
SMILES: [H][C@]12CCc3c(nc(nc3[C@]1(C)C=C(C#N)C(=O)[C@@H]2C)-c1ccncc1)-c1ccncc1
InChI Key: InChIKey=BMMMKLNFEJZQHB-LVJZWUNYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544851 (CHEMBL4647611 | US11292781, Compound T29) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | PubMed | n/a | n/a | 254 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at Gal4-fused RORgammat LBD (unknown origin) by reporter gene assay | Bioorg Med Chem Lett 30: (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544851 (CHEMBL4647611 | US11292781, Compound T29) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | n/a | n/a | 337 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor ROR-gamma (Homo sapiens (Human)) | BDBM50544851 (CHEMBL4647611 | US11292781, Compound T29) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | PubMed | n/a | n/a | 128 | n/a | n/a | n/a | n/a | n/a | n/a |
Reata Pharmaceuticals, Inc. Curated by ChEMBL | Assay Description Inverse agonist activity at RORgammat in human CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by reduction in m... | Bioorg Med Chem Lett 30: (2020) | |||||||||||
More data for this Ligand-Target Pair |