null
SMILES: NS(=O)(=O)OC[C@H]1C[C@H](C[C@@H]1O)Nc1ncncc1C(=O)c1cc(C2OCCc3ccc(Cl)cc23)c(Cl)s1
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SUMO-activating enzyme subunit 1/2 (Homo sapiens (Human)) | BDBM50575595![]() (CHEMBL4849766) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant SAE (unknown origin) assessed as reduction in transfer of SUMO1 to UBC9 using SUMO1 as a substrate in presence of ATP at Km... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01491 BindingDB Entry DOI: 10.7270/Q2PK0KZ8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NEDD8-activating enzyme E1 catalytic subunit (Homo sapiens) | BDBM50575595![]() (CHEMBL4849766) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of recombinant NAE (unknown origin) in presence of ATP at Km concentration by HTRF assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01491 BindingDB Entry DOI: 10.7270/Q2PK0KZ8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
SUMO-activating enzyme subunit 1/2 (Homo sapiens (Human)) | BDBM50575595![]() (CHEMBL4849766) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of SAE in human HCT116 cells assessed as redistribution of SUMO2/3 proteins from nucleus to cytosol preincubated for 2 hrs followed by com... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01491 BindingDB Entry DOI: 10.7270/Q2PK0KZ8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
SUMO-activating enzyme subunit 1/2 (Homo sapiens (Human)) | BDBM50575595![]() (CHEMBL4849766) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of SAE in human HCT116 cells assessed as redistribution of SUMO2/3 proteins from nucleus to cytosol preincubated for 2 hrs followed by com... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01491 BindingDB Entry DOI: 10.7270/Q2PK0KZ8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
SUMO-activating enzyme subunit 1/2 (Homo sapiens (Human)) | BDBM50575595![]() (CHEMBL4849766) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of SAE in human HCT116 cells assessed as reduction in redistribution of SUMO2/3 proteins from nucleus to cytosol incubated for 4 hrs by im... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01491 BindingDB Entry DOI: 10.7270/Q2PK0KZ8 | |||||||||||
More data for this Ligand-Target Pair |