null

SMILES: CNC(=O)c1cc(cc2c1OC[C@@]2(C)c1ccccc1)C(=O)N[C@H]1CC[C@H](O)CC1

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50576471   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM50576471 (CHEMBL4851898) Show SMILES CNC(=O)c1cc(cc2c1OC[C@@]2(C)c1ccccc1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:12.14,26.29,wD:23.25,(62.68,-21.5,;62.69,-23.04,;64.03,-23.81,;65.36,-23.03,;64.04,-25.35,;65.37,-26.11,;65.38,-27.66,;64.04,-28.43,;62.7,-27.66,;62.7,-26.12,;61.25,-25.65,;60.34,-26.89,;61.24,-28.13,;59.9,-28.9,;61.23,-29.67,;59.89,-30.43,;59.88,-31.97,;61.21,-32.75,;62.56,-31.98,;62.56,-30.44,;66.71,-28.43,;66.72,-29.97,;68.05,-27.66,;69.38,-28.42,;69.37,-29.96,;70.7,-30.74,;72.04,-29.97,;73.37,-30.75,;72.04,-28.43,;70.71,-27.65,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<5.01E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of 6His-Thr-BRD4 (1 to 477 residues) BD1 domain (unknown origin) incubated for 30 mins by TR-FRET assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00344 BindingDB Entry DOI: 10.7270/Q2S46WSG
					More data for this Ligand-Target Pair
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM50576471 (CHEMBL4851898) Show SMILES CNC(=O)c1cc(cc2c1OC[C@@]2(C)c1ccccc1)C(=O)N[C@H]1CC[C@H](O)CC1 |r,wU:12.14,26.29,wD:23.25,(62.68,-21.5,;62.69,-23.04,;64.03,-23.81,;65.36,-23.03,;64.04,-25.35,;65.37,-26.11,;65.38,-27.66,;64.04,-28.43,;62.7,-27.66,;62.7,-26.12,;61.25,-25.65,;60.34,-26.89,;61.24,-28.13,;59.9,-28.9,;61.23,-29.67,;59.89,-30.43,;59.88,-31.97,;61.21,-32.75,;62.56,-31.98,;62.56,-30.44,;66.71,-28.43,;66.72,-29.97,;68.05,-27.66,;69.38,-28.42,;69.37,-29.96,;70.7,-30.74,;72.04,-29.97,;73.37,-30.75,;72.04,-28.43,;70.71,-27.65,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	316	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of 6His-Thr-BRD4 (1 to 477 residues) BD2 domain Y390A mutant (unknown origin) incubated for 30 mins by TR-FRET assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00344 BindingDB Entry DOI: 10.7270/Q2S46WSG
					More data for this Ligand-Target Pair