null

SMILES: Cc1cn([C@H]2C[C@H]([C@@H](CO)O2)n2cc(CNC(=O)Nc3cccc(c3)S(N)(=O)=O)nn2)c(=O)[nH]c1=O

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50580099   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Carbonic anhydrase 2 (Homo sapiens (Human))	BDBM50580099 (CHEMBL5078071) Show SMILES Cc1cn([C@H]2C[C@H]([C@@H](CO)O2)n2cc(CNC(=O)Nc3cccc(c3)S(N)(=O)=O)nn2)c(=O)[nH]c1=O |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	6.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydration assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00756 BindingDB Entry DOI: 10.7270/Q2V4103G
					More data for this Ligand-Target Pair
Carbonic anhydrase 12 (Homo sapiens (Human))	BDBM50580099 (CHEMBL5078071) Show SMILES Cc1cn([C@H]2C[C@H]([C@@H](CO)O2)n2cc(CNC(=O)Nc3cccc(c3)S(N)(=O)=O)nn2)c(=O)[nH]c1=O |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	8.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human carbonic anhydrase 12 by stopped-flow CO2 hydration assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00756 BindingDB Entry DOI: 10.7270/Q2V4103G
					More data for this Ligand-Target Pair
Carbonic anhydrase 7 (Homo sapiens (Human))	BDBM50580099 (CHEMBL5078071) Show SMILES Cc1cn([C@H]2C[C@H]([C@@H](CO)O2)n2cc(CNC(=O)Nc3cccc(c3)S(N)(=O)=O)nn2)c(=O)[nH]c1=O |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	9.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human carbonic anhydrase 7 by stopped-flow CO2 hydration assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00756 BindingDB Entry DOI: 10.7270/Q2V4103G
					More data for this Ligand-Target Pair
Carbonic anhydrase 5B, mitochondrial (Homo sapiens (Human))	BDBM50580099 (CHEMBL5078071) Show SMILES Cc1cn([C@H]2C[C@H]([C@@H](CO)O2)n2cc(CNC(=O)Nc3cccc(c3)S(N)(=O)=O)nn2)c(=O)[nH]c1=O |r| Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	48	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human carbonic anhydrase 5B by stopped-flow CO2 hydration assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00756 BindingDB Entry DOI: 10.7270/Q2V4103G
					More data for this Ligand-Target Pair
Carbonic anhydrase 1 (Homo sapiens (Human))	BDBM50580099 (CHEMBL5078071) Show SMILES Cc1cn([C@H]2C[C@H]([C@@H](CO)O2)n2cc(CNC(=O)Nc3cccc(c3)S(N)(=O)=O)nn2)c(=O)[nH]c1=O |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	290	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydration assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00756 BindingDB Entry DOI: 10.7270/Q2V4103G
					More data for this Ligand-Target Pair
Carbonic anhydrase 5A, mitochondrial (Homo sapiens (Human))	BDBM50580099 (CHEMBL5078071) Show SMILES Cc1cn([C@H]2C[C@H]([C@@H](CO)O2)n2cc(CNC(=O)Nc3cccc(c3)S(N)(=O)=O)nn2)c(=O)[nH]c1=O |r| Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	3.24E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human carbonic anhydrase 5A by stopped-flow CO2 hydration assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00756 BindingDB Entry DOI: 10.7270/Q2V4103G
					More data for this Ligand-Target Pair
Carbonic anhydrase 9 (Homo sapiens (Human))	BDBM50580099 (CHEMBL5078071) Show SMILES Cc1cn([C@H]2C[C@H]([C@@H](CO)O2)n2cc(CNC(=O)Nc3cccc(c3)S(N)(=O)=O)nn2)c(=O)[nH]c1=O |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human carbonic anhydrase 9 by stopped-flow CO2 hydration assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00756 BindingDB Entry DOI: 10.7270/Q2V4103G
					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50580099 (CHEMBL5078071) Show SMILES Cc1cn([C@H]2C[C@H]([C@@H](CO)O2)n2cc(CNC(=O)Nc3cccc(c3)S(N)(=O)=O)nn2)c(=O)[nH]c1=O |r| Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	850	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of telomerase in human HCT-116 cells by TRAP assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00756 BindingDB Entry DOI: 10.7270/Q2V4103G
					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50580099 (CHEMBL5078071) Show SMILES Cc1cn([C@H]2C[C@H]([C@@H](CO)O2)n2cc(CNC(=O)Nc3cccc(c3)S(N)(=O)=O)nn2)c(=O)[nH]c1=O |r| Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	900	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of telomerase in human COLO 205 cells by TRAP assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00756 BindingDB Entry DOI: 10.7270/Q2V4103G
					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50580099 (CHEMBL5078071) Show SMILES Cc1cn([C@H]2C[C@H]([C@@H](CO)O2)n2cc(CNC(=O)Nc3cccc(c3)S(N)(=O)=O)nn2)c(=O)[nH]c1=O |r| Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of telomerase in human HT-29 cells by TRAP assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00756 BindingDB Entry DOI: 10.7270/Q2V4103G
					More data for this Ligand-Target Pair
Telomerase reverse transcriptase (Homo sapiens (Human))	BDBM50580099 (CHEMBL5078071) Show SMILES Cc1cn([C@H]2C[C@H]([C@@H](CO)O2)n2cc(CNC(=O)Nc3cccc(c3)S(N)(=O)=O)nn2)c(=O)[nH]c1=O |r| Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of telomerase in human SW-620 cells by TRAP assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00756 BindingDB Entry DOI: 10.7270/Q2V4103G
					More data for this Ligand-Target Pair