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SMILES: CCN1CCN(Cc2c(OC)cc(C)[nH]c2=O)C(=O)c2c(Cl)c(ccc12)-c1c(C)noc1C

InChI Key:

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50586163   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))		BDBM50586163
PNG
(CHEMBL5094306)
Show SMILES CCN1CCN(Cc2c(OC)cc(C)[nH]c2=O)C(=O)c2c(Cl)c(ccc12)-c1c(C)noc1C |(.24,-4.48,;-.85,-3.39,;-.45,-1.9,;1.05,-1.54,;1.72,-.17,;1.05,1.21,;2.14,2.3,;3.62,1.9,;4.02,.41,;2.93,-.68,;3.33,-2.17,;5.51,.01,;6.6,1.1,;8.09,.7,;6.2,2.59,;4.71,2.99,;4.31,4.48,;-.46,1.55,;-.85,3.04,;-1.65,.6,;-2.98,1.37,;-2.98,2.91,;-4.32,.6,;-4.32,-.95,;-2.98,-1.71,;-1.65,-.94,;-5.65,1.37,;-7.06,.74,;-7.45,-.74,;-8.09,1.89,;-7.32,3.22,;-5.81,2.9,;-4.72,3.99,)|
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 489n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of EZH2 (unknown origin) using 3H-SAM as substrate incubated for 1 hour by filter binding method

Citation and Details

Article DOI: 10.1021/acsmedchemlett.1c00448
BindingDB Entry DOI: 10.7270/Q2J10735
More data for this
Ligand-Target Pair