null

SMILES: CCC(=C(c1ccc(O)cc1)c1ccc(\C=C\C(=O)NCCCCNC(=O)CCCCCCCn2c(=S)[nH]c3ccccc3c2=O)cc1)c1ccccc1

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50586400   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Estrogen receptor (Homo sapiens (Human))	BDBM50586400 (CHEMBL5086315) Show SMILES CCC(=C(c1ccc(O)cc1)c1ccc(\C=C\C(=O)NCCCCNC(=O)CCCCCCCn2c(=S)[nH]c3ccccc3c2=O)cc1)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at ERalpha (unknown origin) assessed as inhibition of fluorescein-labeled PGC-1 coactivator recruitment incubated for 10 mins mea...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c02230 BindingDB Entry DOI: 10.7270/Q26H4N92
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM50586400 (CHEMBL5086315) Show SMILES CCC(=C(c1ccc(O)cc1)c1ccc(\C=C\C(=O)NCCCCNC(=O)CCCCCCCn2c(=S)[nH]c3ccccc3c2=O)cc1)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at ERalpha (unknown origin) assessed as inhibition of fluorescein-labeled PGC-1 coactivator recruitment incubated for 30 mins mea...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c02230 BindingDB Entry DOI: 10.7270/Q26H4N92
					More data for this Ligand-Target Pair
Estrogen receptor beta (Homo sapiens (Human))	BDBM50586400 (CHEMBL5086315) Show SMILES CCC(=C(c1ccc(O)cc1)c1ccc(\C=C\C(=O)NCCCCNC(=O)CCCCCCCn2c(=S)[nH]c3ccccc3c2=O)cc1)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at ERbeta (unknown origin) assessed as inhibition of fluorescein-labeled PGC-1 coactivator recruitment incubated for 30 mins meas...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c02230 BindingDB Entry DOI: 10.7270/Q26H4N92
					More data for this Ligand-Target Pair
Estrogen receptor beta (Homo sapiens (Human))	BDBM50586400 (CHEMBL5086315) Show SMILES CCC(=C(c1ccc(O)cc1)c1ccc(\C=C\C(=O)NCCCCNC(=O)CCCCCCCn2c(=S)[nH]c3ccccc3c2=O)cc1)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.820	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of fluorescent-labeled E2 from LBD of ERbeta (unknown origin) by TR-FRET assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c02230 BindingDB Entry DOI: 10.7270/Q26H4N92
					More data for this Ligand-Target Pair
Estrogen receptor beta (Homo sapiens (Human))	BDBM50586400 (CHEMBL5086315) Show SMILES CCC(=C(c1ccc(O)cc1)c1ccc(\C=C\C(=O)NCCCCNC(=O)CCCCCCCn2c(=S)[nH]c3ccccc3c2=O)cc1)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at ERbeta (unknown origin) expressed in human U2OS cells assessed as inhibition of E2-induced transactivation by dual luciferase ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c02230 BindingDB Entry DOI: 10.7270/Q26H4N92
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM50586400 (CHEMBL5086315) Show SMILES CCC(=C(c1ccc(O)cc1)c1ccc(\C=C\C(=O)NCCCCNC(=O)CCCCCCCn2c(=S)[nH]c3ccccc3c2=O)cc1)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of fluorescent-labeled E2 from LBD of ERalpha (unknown origin) by TR-FRET assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c02230 BindingDB Entry DOI: 10.7270/Q26H4N92
					More data for this Ligand-Target Pair
Estrogen receptor (Homo sapiens (Human))	BDBM50586400 (CHEMBL5086315) Show SMILES CCC(=C(c1ccc(O)cc1)c1ccc(\C=C\C(=O)NCCCCNC(=O)CCCCCCCn2c(=S)[nH]c3ccccc3c2=O)cc1)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at ERalpha (unknown origin) expressed in human U2OS cells assessed as inhibition of E2-induced transactivation by dual luciferase...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c02230 BindingDB Entry DOI: 10.7270/Q26H4N92
					More data for this Ligand-Target Pair