null
SMILES: Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCCCCCCCOc1cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c13)c1nnc(C)n-21)c1ccc(Cl)cc1
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bromodomain-containing protein 4 [49-170]/DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human)) | BDBM511613 (US11059801, Compound dBET21) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 175 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description AlphaScreen technology was used to detect CRBN-DDB1/BRD4 dimerization induced by dBET molecules. In brief, GST-BRD4[49-170] (Sigma Aldrich) and CRBN-... | Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA damage-binding protein 1/Protein cereblon (Homo sapiens (Human)) | BDBM511613 (US11059801, Compound dBET21) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB... | Citation and Details BindingDB Entry DOI: 10.7270/Q2G44TFM | |||||||||||
More data for this Ligand-Target Pair |