null
SMILES: Oc1ccc2C(=C(CSc2c1)c1ccc(Cl)cc1F)c1ccc(O[C@H]2CCN(CCCF)C2)cc1
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Estrogen receptor [298-554] (Homo sapiens (Human)) | BDBM521194![]() (3-(4-chloro-2- fluoro-phenyl)- 4-[4-[(3S)-1-(3- fl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8BT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor [298-554,Y537S] (Homo sapiens (Human)) | BDBM521194![]() (3-(4-chloro-2- fluoro-phenyl)- 4-[4-[(3S)-1-(3- fl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8BT3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Estrogen receptor [298-554,D538G] (Homo sapiens (Human)) | BDBM521194![]() (3-(4-chloro-2- fluoro-phenyl)- 4-[4-[(3S)-1-(3- fl...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | US Patent | n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonistic potency of compounds was evaluated using LanthaScreenŽ TR-FRET ERα Coactivator Assay (ThermoFisher) with modifications. It is a com... | Citation and Details BindingDB Entry DOI: 10.7270/Q2NZ8BT3 | |||||||||||
More data for this Ligand-Target Pair |