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null

SMILES: COCc1nn(Cc2ccc(Cn3ccccc3=O)cc2)cc1C(=O)NCc1ncc(Cl)cc1C#N

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 528091
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Plasma kallikrein (Homo sapiens (Human))	BDBM528091 (N-[(5-chloro-3-cyanopyridin-2-yl)methyl]-3-(methox...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	187	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Plasma kallikrein inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MG7SP5
TBA					More data for this Ligand-Target Pair
Kallikrein-1 (Homo sapiens (Human))	BDBM528091 (N-[(5-chloro-3-cyanopyridin-2-yl)methyl]-3-(methox...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description KLK1 inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MG7SP5
TBA					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM528091 (N-[(5-chloro-3-cyanopyridin-2-yl)methyl]-3-(methox...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00921 BindingDB Entry DOI: 10.7270/Q2HT2TBQ
TBA					More data for this Ligand-Target Pair
Coagulation factor XII (Homo sapiens (Human))	BDBM528091 (N-[(5-chloro-3-cyanopyridin-2-yl)methyl]-3-(methox...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Factor XIIa inhibitory activity in vitro was determined using standard published methods (see e.g. Shori et al., Biochem. Pharmacol., 1992, 43, 1209;...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MG7SP5
TBA					More data for this Ligand-Target Pair
Coagulation factor XI (Homo sapiens (Human))	BDBM528091 (N-[(5-chloro-3-cyanopyridin-2-yl)methyl]-3-(methox...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description FXIa inhibitory activity in vitro was determined using standard published methods (see e.g. Johansen et al., Int. J. Tiss. Reac. 1986, 8, 185; Shori ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MG7SP5
TBA					More data for this Ligand-Target Pair