null
SMILES: CO[C@@H](c1ccc(F)cc1)C(F)(F)CNC(=O)c1c(C)ccc(c1F)-c1ccn2nc(N)nc2c1
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mixed lineage kinase domain-like protein (Homo sapiens) | BDBM534497 (3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022086828 | n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description HT29-L23 human colorectal adenocarcinoma cells were maintained in RPMI 1640 medium containing 10% heat-inactivated FBS, 1% Penicillin-Streptomycin an... | Citation and Details BindingDB Entry DOI: 10.7270/Q2M32ZZ4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM534497 (3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022086828 | n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE... | Citation and Details BindingDB Entry DOI: 10.7270/Q2M32ZZ4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mixed lineage kinase domain-like protein (Homo sapiens) | BDBM534497 (3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022086828 | n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description HT29-L23 human colorectal adenocarcinoma cells were maintained in RPMI 1640 medium containing 10% heat-inactivated FBS, 1% Penicillin-Streptomycin an... | Citation and Details BindingDB Entry DOI: 10.7270/Q2M32ZZ4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human)) | BDBM534497 (3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | WIPO WO2022086828 | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE... | Citation and Details BindingDB Entry DOI: 10.7270/Q2M32ZZ4 | |||||||||||
More data for this Ligand-Target Pair |