Found 12 hits for monomerid = 85026 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
HTR4
(RAT) | BDBM85026
(N-(1-Butylpiperidine-4-ylmethyl)-1,2-(trimethylene...)Show InChI InChI=1S/C22H31N3O2/c1-2-3-11-24-13-9-17(10-14-24)16-23-21(26)20-18-7-4-5-8-19(18)25-12-6-15-27-22(20)25/h4-5,7-8,17H,2-3,6,9-16H2,1H3,(H,23,26) | UniProtKB/SwissProt
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| Article PubMed
| 0.00560 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS UPR 9023
Curated by PDSP Ki Database
| |
Neuroreport 8: 3189-96 (1997)
Article DOI: 10.1097/00001756-199710200-00002 BindingDB Entry DOI: 10.7270/Q2TD9VWM |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 4 (5-HT4)
(Homo sapiens (Human)) | BDBM85026
(N-(1-Butylpiperidine-4-ylmethyl)-1,2-(trimethylene...)Show InChI InChI=1S/C22H31N3O2/c1-2-3-11-24-13-9-17(10-14-24)16-23-21(26)20-18-7-4-5-8-19(18)25-12-6-15-27-22(20)25/h4-5,7-8,17H,2-3,6,9-16H2,1H3,(H,23,26) | UniProtKB/SwissProt UniProtKB/TrEMBL
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| Article PubMed
| 0.0100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS UPR 9023
Curated by PDSP Ki Database
| |
Neuroreport 8: 3189-96 (1997)
Article DOI: 10.1097/00001756-199710200-00002 BindingDB Entry DOI: 10.7270/Q2TD9VWM |
More data for this Ligand-Target Pair | |
Serotonin (5-HT) receptor
(Homo sapiens (Human)) | BDBM85026
(N-(1-Butylpiperidine-4-ylmethyl)-1,2-(trimethylene...)Show InChI InChI=1S/C22H31N3O2/c1-2-3-11-24-13-9-17(10-14-24)16-23-21(26)20-18-7-4-5-8-19(18)25-12-6-15-27-22(20)25/h4-5,7-8,17H,2-3,6,9-16H2,1H3,(H,23,26) | UniProtKB/SwissProt UniProtKB/TrEMBL
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| Article PubMed
| 0.0525 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Drug Discovery Laboratory AS
Curated by ChEMBL
| Assay Description Displacement of [3H]GR113808 from human 5HT4 receptor expressed in HEK293 cells by liquid scintillation counting |
Bioorg Med Chem 18: 8600-13 (2010)
Article DOI: 10.1016/j.bmc.2010.10.011 BindingDB Entry DOI: 10.7270/Q2FR00GH |
More data for this Ligand-Target Pair | |
Serotonin (5-HT) receptor
(Homo sapiens (Human)) | BDBM85026
(N-(1-Butylpiperidine-4-ylmethyl)-1,2-(trimethylene...)Show InChI InChI=1S/C22H31N3O2/c1-2-3-11-24-13-9-17(10-14-24)16-23-21(26)20-18-7-4-5-8-19(18)25-12-6-15-27-22(20)25/h4-5,7-8,17H,2-3,6,9-16H2,1H3,(H,23,26) | UniProtKB/SwissProt UniProtKB/TrEMBL
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| Article PubMed
| 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Drug Discovery Laboratory AS
Curated by ChEMBL
| Assay Description Displacement of [3H]GR113808 from human 5-HT4B receptor expressed in HEK293 cells after 1 hr by liquid scintillation counting analysis |
Eur J Med Chem 64: 629-37 (2013)
Article DOI: 10.1016/j.ejmech.2013.03.060 BindingDB Entry DOI: 10.7270/Q27947NT |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 4 (5-HT4)
(Homo sapiens (Human)) | BDBM85026
(N-(1-Butylpiperidine-4-ylmethyl)-1,2-(trimethylene...)Show InChI InChI=1S/C22H31N3O2/c1-2-3-11-24-13-9-17(10-14-24)16-23-21(26)20-18-7-4-5-8-19(18)25-12-6-15-27-22(20)25/h4-5,7-8,17H,2-3,6,9-16H2,1H3,(H,23,26) | UniProtKB/SwissProt UniProtKB/TrEMBL
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| Article PubMed
| 0.158 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Angelini Santa Palomba Research Center
Curated by ChEMBL
| Assay Description Displacement of [3H](1-(2-(methylsulfonamido)ethyl)piperidin-4-yl)methyl 1-methyl-1H-indole-3-carboxylate from human 5HT4R expressed in HEK293 cells |
J Med Chem 55: 9446-66 (2012)
Article DOI: 10.1021/jm300573d BindingDB Entry DOI: 10.7270/Q27082JT |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 4 (5-HT4)
(Homo sapiens (Human)) | BDBM85026
(N-(1-Butylpiperidine-4-ylmethyl)-1,2-(trimethylene...)Show InChI InChI=1S/C22H31N3O2/c1-2-3-11-24-13-9-17(10-14-24)16-23-21(26)20-18-7-4-5-8-19(18)25-12-6-15-27-22(20)25/h4-5,7-8,17H,2-3,6,9-16H2,1H3,(H,23,26) | UniProtKB/SwissProt UniProtKB/TrEMBL
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| Article PubMed
| 0.300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS UPR 9023
Curated by PDSP Ki Database
| |
Neuroreport 8: 3189-96 (1997)
Article DOI: 10.1097/00001756-199710200-00002 BindingDB Entry DOI: 10.7270/Q2TD9VWM |
More data for this Ligand-Target Pair | |
HTR4
(GUINEA PIG) | BDBM85026
(N-(1-Butylpiperidine-4-ylmethyl)-1,2-(trimethylene...)Show InChI InChI=1S/C22H31N3O2/c1-2-3-11-24-13-9-17(10-14-24)16-23-21(26)20-18-7-4-5-8-19(18)25-12-6-15-27-22(20)25/h4-5,7-8,17H,2-3,6,9-16H2,1H3,(H,23,26) | UniProtKB/SwissProt
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| Article PubMed
| 0.390 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Bioscience
Curated by PDSP Ki Database
| |
FASEB J 10: 1398-407 (1996)
Article DOI: 10.1096/fasebj.10.12.8903510 BindingDB Entry DOI: 10.7270/Q2TQ602G |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 4 (5-HT4)
(Homo sapiens (Human)) | BDBM85026
(N-(1-Butylpiperidine-4-ylmethyl)-1,2-(trimethylene...)Show InChI InChI=1S/C22H31N3O2/c1-2-3-11-24-13-9-17(10-14-24)16-23-21(26)20-18-7-4-5-8-19(18)25-12-6-15-27-22(20)25/h4-5,7-8,17H,2-3,6,9-16H2,1H3,(H,23,26) | UniProtKB/SwissProt UniProtKB/TrEMBL
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| Article PubMed
| 0.398 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oslo
Curated by ChEMBL
| Assay Description Displacement of [3H]GR113808 from human 5HT4b receptor expressed in HEK293 cell membranes |
Bioorg Med Chem Lett 24: 4598-602 (2014)
Article DOI: 10.1016/j.bmcl.2014.06.083 BindingDB Entry DOI: 10.7270/Q28W3FW7 |
More data for this Ligand-Target Pair | |
HTR4
(RAT) | BDBM85026
(N-(1-Butylpiperidine-4-ylmethyl)-1,2-(trimethylene...)Show InChI InChI=1S/C22H31N3O2/c1-2-3-11-24-13-9-17(10-14-24)16-23-21(26)20-18-7-4-5-8-19(18)25-12-6-15-27-22(20)25/h4-5,7-8,17H,2-3,6,9-16H2,1H3,(H,23,26) | UniProtKB/SwissProt
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| Article PubMed
| 0.470 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
CNRS UPR 9023
Curated by PDSP Ki Database
| |
Neuroreport 8: 3189-96 (1997)
Article DOI: 10.1097/00001756-199710200-00002 BindingDB Entry DOI: 10.7270/Q2TD9VWM |
More data for this Ligand-Target Pair | |
HTR4
(GUINEA PIG) | BDBM85026
(N-(1-Butylpiperidine-4-ylmethyl)-1,2-(trimethylene...)Show InChI InChI=1S/C22H31N3O2/c1-2-3-11-24-13-9-17(10-14-24)16-23-21(26)20-18-7-4-5-8-19(18)25-12-6-15-27-22(20)25/h4-5,7-8,17H,2-3,6,9-16H2,1H3,(H,23,26) | UniProtKB/SwissProt
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| Article PubMed
| 1.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oslo
Curated by ChEMBL
| Assay Description Displacement of [125I]SB207710 from 5-HT4 receptor in guinea pig brain membranes |
Bioorg Med Chem 21: 7134-45 (2013)
Article DOI: 10.1016/j.bmc.2013.09.004 BindingDB Entry DOI: 10.7270/Q2G44RRT |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 3A
(Homo sapiens (Human)) | BDBM85026
(N-(1-Butylpiperidine-4-ylmethyl)-1,2-(trimethylene...)Show InChI InChI=1S/C22H31N3O2/c1-2-3-11-24-13-9-17(10-14-24)16-23-21(26)20-18-7-4-5-8-19(18)25-12-6-15-27-22(20)25/h4-5,7-8,17H,2-3,6,9-16H2,1H3,(H,23,26) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Université de Caen
Curated by ChEMBL
| Assay Description Binding affinity at 5HT3 receptor |
Bioorg Med Chem 17: 2607-22 (2009)
Article DOI: 10.1016/j.bmc.2008.11.045 BindingDB Entry DOI: 10.7270/Q2CJ8DCG |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 4 (5-HT4)
(Homo sapiens (Human)) | BDBM85026
(N-(1-Butylpiperidine-4-ylmethyl)-1,2-(trimethylene...)Show InChI InChI=1S/C22H31N3O2/c1-2-3-11-24-13-9-17(10-14-24)16-23-21(26)20-18-7-4-5-8-19(18)25-12-6-15-27-22(20)25/h4-5,7-8,17H,2-3,6,9-16H2,1H3,(H,23,26) | UniProtKB/SwissProt UniProtKB/TrEMBL
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| PubMed
| n/a | n/a | 0.630 | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals
Curated by ChEMBL
| Assay Description Binding affinity was determined against 5-hydroxytryptamine 3 receptor |
J Med Chem 38: 4760-3 (1996)
BindingDB Entry DOI: 10.7270/Q2B56M1M |
More data for this Ligand-Target Pair | |