BDBM92406 PDK1 inhibitor, 7
SMILES: Fc1ccc(Cn2cccc(C(=O)NC(COc3ccc4[nH]c(=O)[nH]c4c3)c3ccccc3)c2=O)cc1F
InChI Key: InChIKey=AHMXYULEXZAPCS-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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3-phosphoinositide dependent protein kinase-1 (Homo sapiens (Human)) | BDBM92406 (PDK1 inhibitor, 7) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 1 | n/a | n/a | n/a | n/a |
Merck Research Laboratories | Assay Description Enzyme potency (PDK1 EC50)was determined using recombinant, purified full-length human PDK1 enzyme and AKT-Thr-308-tide as substrate. | J Biol Chem 286: 6433-48 (2011) Article DOI: 10.1074/jbc.M110.156463 BindingDB Entry DOI: 10.7270/Q21C1VGQ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |