BDBM99419 US8497281, 197::US9120769, 130::US9663470, 130

SMILES: Nc1cc(ccc1F)C(=O)N1CCCC2[C@@H]1Cc1ccccc21

InChI Key: InChIKey=UGNYNFVKUHGDMO-PKHIMPSTSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 99419   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM99419 (US8497281, 197 | US9120769, 130 | US9663470, 130) Show SMILES Nc1cc(ccc1F)C(=O)N1CCCC2[C@@H]1Cc1ccccc21 |r| Show InChI InChI=1S/C19H19FN2O/c20-16-8-7-13(10-17(16)21)19(23)22-9-3-6-15-14-5-2-1-4-12(14)11-18(15)22/h1-2,4-5,7-8,10,15,18H,3,6,9,11,21H2/t15?,18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.14E+3	n/a	n/a	n/a	n/a	6.0	37
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH US Patent					Assay Description In vitro inhibition of 11beta-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluoresence) technology (cisbio international...				US Patent US8497281 (2013) BindingDB Entry DOI: 10.7270/Q2G44NXT
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM99419 (US8497281, 197 | US9120769, 130 | US9663470, 130) Show SMILES Nc1cc(ccc1F)C(=O)N1CCCC2[C@@H]1Cc1ccccc21 |r| Show InChI InChI=1S/C19H19FN2O/c20-16-8-7-13(10-17(16)21)19(23)22-9-3-6-15-14-5-2-1-4-12(14)11-18(15)22/h1-2,4-5,7-8,10,15,18H,3,6,9,11,21H2/t15?,18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.14E+3	n/a	n/a	n/a	n/a	n/a	n/a
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International Gmbh US Patent					Assay Description In vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internatio...				US Patent US9663470 (2017) BindingDB Entry DOI: 10.7270/Q2V40X8H
					More data for this Ligand-Target Pair
11-beta-hydroxysteroid dehydrogenase 1 (Homo sapiens (Human))	BDBM99419 (US8497281, 197 | US9120769, 130 | US9663470, 130) Show SMILES Nc1cc(ccc1F)C(=O)N1CCCC2[C@@H]1Cc1ccccc21 |r| Show InChI InChI=1S/C19H19FN2O/c20-16-8-7-13(10-17(16)21)19(23)22-9-3-6-15-14-5-2-1-4-12(14)11-18(15)22/h1-2,4-5,7-8,10,15,18H,3,6,9,11,21H2/t15?,18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.14E+3	n/a	n/a	n/a	n/a	6.0	n/a
Boehringer-Ingelheim International GmbH US Patent					Assay Description n vitro inhibition of 11β-HSD1 by test compounds is determined with HTRF (Homogeneous Time-Resolved Fluorescence) technology (cisbio internation...				US Patent US9120769 (2015) BindingDB Entry DOI: 10.7270/Q2XW4HK9
					More data for this Ligand-Target Pair