Found 13 hits in this display Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Lysosomal acid glucosylceramidase
(Homo sapiens (Human)) | BDBM50182798
((3R,4r,5S)-piperidine-3,4,5-triol | 1,5-Dideoxy-1,...)Show InChI InChI=1S/C5H11NO3/c7-3-1-6-2-4(8)5(3)9/h3-9H,1-2H2/t3-,4+,5+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University Graz
Curated by ChEMBL
| Assay Description Inhibition of human lysosomal beta-glucocerebrosidase |
Bioorg Med Chem Lett 24: 2777-80 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.069 BindingDB Entry DOI: 10.7270/Q2RV0Q8B |
More data for this Ligand-Target Pair | |
Lysosomal acid glucosylceramidase
(Homo sapiens (Human)) | BDBM50182798
((3R,4r,5S)-piperidine-3,4,5-triol | 1,5-Dideoxy-1,...)Show InChI InChI=1S/C5H11NO3/c7-3-1-6-2-4(8)5(3)9/h3-9H,1-2H2/t3-,4+,5+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | 5.0 | n/a |
University of British Columbia
Curated by ChEMBL
| Assay Description Competitive inhibition of wild type human glucocerebrosidase using 2,4-dinitrophenyl beta-D-glucopyranoside as substrate after 3 mins by Dixon and Li... |
J Med Chem 55: 2737-45 (2012)
Article DOI: 10.1021/jm201633y BindingDB Entry DOI: 10.7270/Q2639QSX |
More data for this Ligand-Target Pair | |
Beta-xylosidase
(Thermoanaerobacter saccharolyticum) | BDBM50182802
(5-(dimethylamino)-N-(6-((3R,4r,5S)-3,4,5-trihydrox...)Show SMILES CN(C)c1cccc2c(cccc12)S(=O)(=O)NCCCCCCN1C[C@H](O)[C@@H](O)[C@H](O)C1 Show InChI InChI=1S/C23H35N3O5S/c1-25(2)19-11-7-10-18-17(19)9-8-12-22(18)32(30,31)24-13-5-3-4-6-14-26-15-20(27)23(29)21(28)16-26/h7-12,20-21,23-24,27-29H,3-6,13-16H2,1-2H3/t20-,21+,23+ | PDB MMDB
UniProtKB/SwissProt
B.MOAD GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 7.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Technische Universität Graz
Curated by ChEMBL
| Assay Description Inhibition of Thermoanaerobacterium saccharolyticum beta-xylosidase |
Bioorg Med Chem Lett 16: 2067-70 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.095 BindingDB Entry DOI: 10.7270/Q26Q1WV2 |
More data for this Ligand-Target Pair | |
Beta-glucosidase
(Agrobacterium tumefaciens) | BDBM50182798
((3R,4r,5S)-piperidine-3,4,5-triol | 1,5-Dideoxy-1,...)Show InChI InChI=1S/C5H11NO3/c7-3-1-6-2-4(8)5(3)9/h3-9H,1-2H2/t3-,4+,5+ | UniProtKB/SwissProt
GoogleScholar AffyNet
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| Article PubMed
| 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Technical University Graz
Curated by ChEMBL
| Assay Description Inhibition of Agrobacterium sp. beta glucosidase |
Bioorg Med Chem Lett 24: 2777-80 (2014)
Article DOI: 10.1016/j.bmcl.2014.03.069 BindingDB Entry DOI: 10.7270/Q2RV0Q8B |
More data for this Ligand-Target Pair | |
Beta-xylosidase
(Thermoanaerobacter saccharolyticum) | BDBM50182798
((3R,4r,5S)-piperidine-3,4,5-triol | 1,5-Dideoxy-1,...)Show InChI InChI=1S/C5H11NO3/c7-3-1-6-2-4(8)5(3)9/h3-9H,1-2H2/t3-,4+,5+ | PDB MMDB
UniProtKB/SwissProt
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| Article PubMed
| 2.06E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Technische Universität Graz
Curated by ChEMBL
| Assay Description Inhibition of Thermoanaerobacterium saccharolyticum beta-xylosidase |
Bioorg Med Chem Lett 16: 2067-70 (2006)
Article DOI: 10.1016/j.bmcl.2006.01.095 BindingDB Entry DOI: 10.7270/Q26Q1WV2 |
More data for this Ligand-Target Pair | |
Lysosomal acid glucosylceramidase
(Homo sapiens (Human)) | BDBM50182798
((3R,4r,5S)-piperidine-3,4,5-triol | 1,5-Dideoxy-1,...)Show InChI InChI=1S/C5H11NO3/c7-3-1-6-2-4(8)5(3)9/h3-9H,1-2H2/t3-,4+,5+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114499 BindingDB Entry DOI: 10.7270/Q2Z89HFH |
More data for this Ligand-Target Pair | |
Lysosomal acid glucosylceramidase
(Homo sapiens (Human)) | BDBM50182798
((3R,4r,5S)-piperidine-3,4,5-triol | 1,5-Dideoxy-1,...)Show InChI InChI=1S/C5H11NO3/c7-3-1-6-2-4(8)5(3)9/h3-9H,1-2H2/t3-,4+,5+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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Patents
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| Article PubMed
| n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Inhibition of human lysosomal beta-glucosidase |
Bioorg Med Chem 16: 7330-6 (2008)
Article DOI: 10.1016/j.bmc.2008.06.026 BindingDB Entry DOI: 10.7270/Q27D2W2B |
More data for this Ligand-Target Pair | |
Lysosomal acid glucosylceramidase
(Homo sapiens (Human)) | BDBM50182798
((3R,4r,5S)-piperidine-3,4,5-triol | 1,5-Dideoxy-1,...)Show InChI InChI=1S/C5H11NO3/c7-3-1-6-2-4(8)5(3)9/h3-9H,1-2H2/t3-,4+,5+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
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| Article
| n/a | n/a | 8.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Compound was evaluated for inhibition of beta-glucosidase from almonds(sigma G 4511). |
Bioorg Med Chem Lett 6: 553-558 (1996)
Article DOI: 10.1016/0960-894X(96)00068-6 BindingDB Entry DOI: 10.7270/Q2ZS2WHG |
More data for this Ligand-Target Pair | |
Beta-galactosidase
(Homo sapiens (Human)) | BDBM50182798
((3R,4r,5S)-piperidine-3,4,5-triol | 1,5-Dideoxy-1,...)Show InChI InChI=1S/C5H11NO3/c7-3-1-6-2-4(8)5(3)9/h3-9H,1-2H2/t3-,4+,5+ | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
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| Article
| n/a | n/a | 4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Compound was evaluated for inhibition of beta-galactosidase from aspergillus oryzae (sigma G 7256). |
Bioorg Med Chem Lett 6: 553-558 (1996)
Article DOI: 10.1016/0960-894X(96)00068-6 BindingDB Entry DOI: 10.7270/Q2ZS2WHG |
More data for this Ligand-Target Pair | |
Alpha-galactosidase A
(Homo sapiens (Human)) | BDBM50182798
((3R,4r,5S)-piperidine-3,4,5-triol | 1,5-Dideoxy-1,...)Show InChI InChI=1S/C5H11NO3/c7-3-1-6-2-4(8)5(3)9/h3-9H,1-2H2/t3-,4+,5+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
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| Article
| n/a | n/a | 4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Compound was evaluated for inhibition of alpha-galactosidase from green coffee beans (sigma G 8507). |
Bioorg Med Chem Lett 6: 553-558 (1996)
Article DOI: 10.1016/0960-894X(96)00068-6 BindingDB Entry DOI: 10.7270/Q2ZS2WHG |
More data for this Ligand-Target Pair | |
alpha-1,2-Mannosidase
(Glycine max) | BDBM50182798
((3R,4r,5S)-piperidine-3,4,5-triol | 1,5-Dideoxy-1,...)Show InChI InChI=1S/C5H11NO3/c7-3-1-6-2-4(8)5(3)9/h3-9H,1-2H2/t3-,4+,5+ | KEGG
UniProtKB/TrEMBL
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| Article
| n/a | n/a | 3.60E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of jack bean alpha-mannosidase |
Bioorg Med Chem Lett 6: 553-558 (1996)
Article DOI: 10.1016/0960-894X(96)00068-6 BindingDB Entry DOI: 10.7270/Q2ZS2WHG |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Homo sapiens (Human)) | BDBM50182798
((3R,4r,5S)-piperidine-3,4,5-triol | 1,5-Dideoxy-1,...)Show InChI InChI=1S/C5H11NO3/c7-3-1-6-2-4(8)5(3)9/h3-9H,1-2H2/t3-,4+,5+ | PDB
NCI pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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Patents
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| Article
| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Compound was evaluated for inhibition of alpha-glucosidase from yeast(sigma G 7256). |
Bioorg Med Chem Lett 6: 553-558 (1996)
Article DOI: 10.1016/0960-894X(96)00068-6 BindingDB Entry DOI: 10.7270/Q2ZS2WHG |
More data for this Ligand-Target Pair | |
Tissue alpha-L-fucosidase
(Homo sapiens (Human)) | BDBM50182798
((3R,4r,5S)-piperidine-3,4,5-triol | 1,5-Dideoxy-1,...)Show InChI InChI=1S/C5H11NO3/c7-3-1-6-2-4(8)5(3)9/h3-9H,1-2H2/t3-,4+,5+ | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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| Article
| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Compound was evaluated for inhibition of alpha-fucosidase from bovine kidney(sigma F 5884). |
Bioorg Med Chem Lett 6: 553-558 (1996)
Article DOI: 10.1016/0960-894X(96)00068-6 BindingDB Entry DOI: 10.7270/Q2ZS2WHG |
More data for this Ligand-Target Pair | |