Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
C-C chemokine receptor type 1 (Homo sapiens (Human)) | BDBM50056504 (CHEMBL3334824) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol Myers Squibb Company Curated by ChEMBL | Assay Description Displacement of [125I]MIP-1alpha from CCR1 in human THP1 cells | J Med Chem 57: 7550-64 (2014) Article DOI: 10.1021/jm5003167 BindingDB Entry DOI: 10.7270/Q2TB18JC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 1 (Homo sapiens (Human)) | BDBM50056504 (CHEMBL3334824) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Curated by ChEMBL | Assay Description Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assay | Bioorg Med Chem Lett 29: 435-440 (2019) Article DOI: 10.1016/j.bmcl.2018.11.015 BindingDB Entry DOI: 10.7270/Q2D79FSV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 1 (Homo sapiens (Human)) | BDBM50056504 (CHEMBL3334824) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Curated by ChEMBL | Assay Description Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha... | Bioorg Med Chem Lett 29: 435-440 (2019) Article DOI: 10.1016/j.bmcl.2018.11.015 BindingDB Entry DOI: 10.7270/Q2D79FSV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 1 (Homo sapiens (Human)) | BDBM50056504 (CHEMBL3334824) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol Myers Squibb Company Curated by ChEMBL | Assay Description Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of HCC4-induced chemotaxis after 60 mins | J Med Chem 57: 7550-64 (2014) Article DOI: 10.1021/jm5003167 BindingDB Entry DOI: 10.7270/Q2TB18JC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 1 (Homo sapiens (Human)) | BDBM50056504 (CHEMBL3334824) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol Myers Squibb Company Curated by ChEMBL | Assay Description Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of RANTES-induced chemotaxis after 60 mins | J Med Chem 57: 7550-64 (2014) Article DOI: 10.1021/jm5003167 BindingDB Entry DOI: 10.7270/Q2TB18JC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 1 (Homo sapiens (Human)) | BDBM50056504 (CHEMBL3334824) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol Myers Squibb Company Curated by ChEMBL | Assay Description Displacement of [125I]hMIP-1alpha from CCR1 in human PBMC | J Med Chem 57: 7550-64 (2014) Article DOI: 10.1021/jm5003167 BindingDB Entry DOI: 10.7270/Q2TB18JC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 1 (Homo sapiens (Human)) | BDBM50056504 (CHEMBL3334824) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol Myers Squibb Company Curated by ChEMBL | Assay Description Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha-induced chemotaxis after 60 mins | J Med Chem 57: 7550-64 (2014) Article DOI: 10.1021/jm5003167 BindingDB Entry DOI: 10.7270/Q2TB18JC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 1 (Homo sapiens (Human)) | BDBM50056504 (CHEMBL3334824) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol Myers Squibb Company Curated by ChEMBL | Assay Description Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MIP-1alpha induced chemotaxis after 60 mins | J Med Chem 57: 7550-64 (2014) Article DOI: 10.1021/jm5003167 BindingDB Entry DOI: 10.7270/Q2TB18JC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 1 (Homo sapiens (Human)) | BDBM50056504 (CHEMBL3334824) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol Myers Squibb Company Curated by ChEMBL | Assay Description Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of HCC1-induced chemotaxis after 60 mins | J Med Chem 57: 7550-64 (2014) Article DOI: 10.1021/jm5003167 BindingDB Entry DOI: 10.7270/Q2TB18JC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 1 (Homo sapiens (Human)) | BDBM50056504 (CHEMBL3334824) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol Myers Squibb Company Curated by ChEMBL | Assay Description Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MCP3-induced chemotaxis after 60 mins | J Med Chem 57: 7550-64 (2014) Article DOI: 10.1021/jm5003167 BindingDB Entry DOI: 10.7270/Q2TB18JC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 1 (Homo sapiens (Human)) | BDBM50056504 (CHEMBL3334824) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol Myers Squibb Company Curated by ChEMBL | Assay Description Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of MPIF1-induced chemotaxis after 60 mins | J Med Chem 57: 7550-64 (2014) Article DOI: 10.1021/jm5003167 BindingDB Entry DOI: 10.7270/Q2TB18JC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 1 (Homo sapiens (Human)) | BDBM50056504 (CHEMBL3334824) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol Myers Squibb Company Curated by ChEMBL | Assay Description Antagonist activity at CCR1 receptor in human THP1 cells assessed as inhibition of LKN1-induced chemotaxis after 60 mins | J Med Chem 57: 7550-64 (2014) Article DOI: 10.1021/jm5003167 BindingDB Entry DOI: 10.7270/Q2TB18JC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 1 (Homo sapiens (Human)) | BDBM50056504 (CHEMBL3334824) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol Myers Squibb Company Curated by ChEMBL | Assay Description Antagonist activity at CCR1 receptor in human whole blood assessed as blocked of MIP-1alpha-mediated CD11b upregulation preincubated for 1 hr | J Med Chem 57: 7550-64 (2014) Article DOI: 10.1021/jm5003167 BindingDB Entry DOI: 10.7270/Q2TB18JC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 1 (Homo sapiens (Human)) | BDBM50056504 (CHEMBL3334824) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol Myers Squibb Company Curated by ChEMBL | Assay Description Antagonist activity at CCR1 receptor in human whole blood assessed as blocked of LKN1-mediated CD11b upregulation preincubated for 1 hr | J Med Chem 57: 7550-64 (2014) Article DOI: 10.1021/jm5003167 BindingDB Entry DOI: 10.7270/Q2TB18JC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Chemokine (C-C motif) receptor 1 (Canis familiaris) | BDBM50056504 (CHEMBL3334824) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 635 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol Myers Squibb Company Curated by ChEMBL | Assay Description Displacement of [125I]hMIP-1alpha from dog PBMC CCR1 | J Med Chem 57: 7550-64 (2014) Article DOI: 10.1021/jm5003167 BindingDB Entry DOI: 10.7270/Q2TB18JC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-C chemokine receptor type 1 (Mus musculus) | BDBM50056504 (CHEMBL3334824) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol Myers Squibb Company Curated by ChEMBL | Assay Description Displacement of [125I]hMIP-1alpha from mouse CCR1 | J Med Chem 57: 7550-64 (2014) Article DOI: 10.1021/jm5003167 BindingDB Entry DOI: 10.7270/Q2TB18JC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nuclear receptor subfamily 1 group I member 2 (Homo sapiens (Human)) | BDBM50056504 (CHEMBL3334824) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | >2.50E+4 | n/a | n/a | n/a | n/a |
Bristol Myers Squibb Company Curated by ChEMBL | Assay Description Transactivation of human full-length PXR transfected in human HepG2 cells after 24 hrs by luciferase reporter gene assay | J Med Chem 57: 7550-64 (2014) Article DOI: 10.1021/jm5003167 BindingDB Entry DOI: 10.7270/Q2TB18JC | |||||||||||
More data for this Ligand-Target Pair |