Found 93 hits with Last Name = 'fernandez-carvajal' and Initial = 'a' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50465610
(CHEMBL4295040)Show SMILES COC(=O)[C@H](Cc1c[nH]c2ccccc12)N(Cc1ccccc1)Cc1ccccc1 |r| Show InChI InChI=1S/C26H26N2O2/c1-30-26(29)25(16-22-17-27-24-15-9-8-14-23(22)24)28(18-20-10-4-2-5-11-20)19-21-12-6-3-7-13-21/h2-15,17,25,27H,16,18-19H2,1H3/t25-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salerno
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced channel currents by whole cell patch clamp method |
J Med Chem 61: 6140-6152 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00545 BindingDB Entry DOI: 10.7270/Q2FN18V3 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50465611
(CHEMBL4284808)Show InChI InChI=1S/C24H30N2/c1-3-9-20(10-4-1)18-26(19-21-11-5-2-6-12-21)16-15-22-17-25-24-14-8-7-13-23(22)24/h1,3-4,7-10,13-14,17,21,25H,2,5-6,11-12,15-16,18-19H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salerno
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced channel currents by whole cell patch clamp method |
J Med Chem 61: 6140-6152 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00545 BindingDB Entry DOI: 10.7270/Q2FN18V3 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50544523
(CHEMBL4647674)Show SMILES [H][C@@]12Cc3c([nH]c4ccccc34)[C@H](N1C(=O)N(Cc1ccc(F)cc1)C2=O)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C26H19ClFN3O2/c27-17-9-7-16(8-10-17)24-23-20(19-3-1-2-4-21(19)29-23)13-22-25(32)30(26(33)31(22)24)14-15-5-11-18(28)12-6-15/h1-12,22,24,29H,13-14H2/t22-,24+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salerno
Curated by ChEMBL
| Assay Description Antagonist activity at human TRPM8 expressed in HEK-293/TRPM8 exon1 K3 cells assessed as inhibition of menthol-induced current response by whole-cell... |
J Med Chem 63: 9672-9694 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00816 BindingDB Entry DOI: 10.7270/Q2GF0Z2X |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50544513
(CHEMBL4649088)Show SMILES [H][C@@]12Cc3c(CN1C(=O)[C@@H](Cc1ccccc1)NC2=O)[nH]c1ccccc31 |r| Show InChI InChI=1S/C21H19N3O2/c25-20-19-11-15-14-8-4-5-9-16(14)22-18(15)12-24(19)21(26)17(23-20)10-13-6-2-1-3-7-13/h1-9,17,19,22H,10-12H2,(H,23,25)/t17-,19+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 6.60 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salerno
Curated by ChEMBL
| Assay Description Antagonist activity at human TRPM8 expressed in HEK-293/TRPM8 exon1 K3 cells assessed as inhibition of menthol-induced current response by whole-cell... |
J Med Chem 63: 9672-9694 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00816 BindingDB Entry DOI: 10.7270/Q2GF0Z2X |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50544531
(CHEMBL4648953)Show SMILES [H][C@@]12Cc3c([nH]c4ccccc34)[C@@H](N1C(=O)N(C2=O)c1cccc(c1)C(F)(F)F)c1ccc(F)cc1 |r| Show InChI InChI=1S/C26H17F4N3O2/c27-16-10-8-14(9-11-16)23-22-19(18-6-1-2-7-20(18)31-22)13-21-24(34)32(25(35)33(21)23)17-5-3-4-15(12-17)26(28,29)30/h1-12,21,23,31H,13H2/t21-,23-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 7.70 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salerno
Curated by ChEMBL
| Assay Description Antagonist activity at human TRPM8 expressed in HEK-293/TRPM8 exon1 K3 cells assessed as inhibition of menthol-induced current response by whole-cell... |
J Med Chem 63: 9672-9694 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00816 BindingDB Entry DOI: 10.7270/Q2GF0Z2X |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50544501
(CHEMBL4647444)Show SMILES COC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1Cc1ccccc1)c1ccccc1 |r| Show InChI InChI=1S/C26H24N2O2/c1-30-26(29)23-16-21-20-14-8-9-15-22(20)27-24(21)25(19-12-6-3-7-13-19)28(23)17-18-10-4-2-5-11-18/h2-15,23,25,27H,16-17H2,1H3/t23-,25+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salerno
Curated by ChEMBL
| Assay Description Antagonist activity at human TRPM8 expressed in HEK-293/TRPM8 exon1 K3 cells assessed as inhibition of menthol-induced current response by whole-cell... |
J Med Chem 63: 9672-9694 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00816 BindingDB Entry DOI: 10.7270/Q2GF0Z2X |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50544506
(CHEMBL4647464)Show SMILES COC(=O)CC[C@H]1N[C@@H](Cc2c1[nH]c1ccccc21)C(=O)NCc1ccc(F)cc1 |r| Show InChI InChI=1S/C23H24FN3O3/c1-30-21(28)11-10-19-22-17(16-4-2-3-5-18(16)27-22)12-20(26-19)23(29)25-13-14-6-8-15(24)9-7-14/h2-9,19-20,26-27H,10-13H2,1H3,(H,25,29)/t19-,20+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salerno
Curated by ChEMBL
| Assay Description Antagonist activity at human TRPM8 expressed in HEK-293/TRPM8 exon1 K3 cells assessed as inhibition of menthol-induced current response by whole-cell... |
J Med Chem 63: 9672-9694 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00816 BindingDB Entry DOI: 10.7270/Q2GF0Z2X |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50544503
(CHEMBL4644158)Show SMILES Fc1ccc(CNC(=O)[C@@H]2Cc3c(CN2)[nH]c2ccccc32)cc1 |r| Show InChI InChI=1S/C19H18FN3O/c20-13-7-5-12(6-8-13)10-22-19(24)17-9-15-14-3-1-2-4-16(14)23-18(15)11-21-17/h1-8,17,21,23H,9-11H2,(H,22,24)/t17-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salerno
Curated by ChEMBL
| Assay Description Antagonist activity at human TRPM8 expressed in HEK-293/TRPM8 exon1 K3 cells assessed as inhibition of menthol-induced current response by whole-cell... |
J Med Chem 63: 9672-9694 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00816 BindingDB Entry DOI: 10.7270/Q2GF0Z2X |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50465610
(CHEMBL4295040)Show SMILES COC(=O)[C@H](Cc1c[nH]c2ccccc12)N(Cc1ccccc1)Cc1ccccc1 |r| Show InChI InChI=1S/C26H26N2O2/c1-30-26(29)25(16-22-17-27-24-15-9-8-14-23(22)24)28(18-20-10-4-2-5-11-20)19-21-12-6-3-7-13-21/h2-15,17,25,27H,16,18-19H2,1H3/t25-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salerno
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced calcium flux incubated for 60 mins by Fluo-4 NW-d... |
J Med Chem 61: 6140-6152 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00545 BindingDB Entry DOI: 10.7270/Q2FN18V3 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50592161
(CHEMBL5198220)Show SMILES COC(=O)[C@H](Cc1ccc(cc1)[N+]([O-])=O)N(Cc1ccccc1)Cc1ccccc1 |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114435 BindingDB Entry DOI: 10.7270/Q2ZP4B36 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50544500
(CHEMBL4649195)Show SMILES COC(=O)C(Cc1c[nH]c2ccccc12)N(Cc1ccccc1)Cc1ccccc1 Show InChI InChI=1S/C26H26N2O2/c1-30-26(29)25(16-22-17-27-24-15-9-8-14-23(22)24)28(18-20-10-4-2-5-11-20)19-21-12-6-3-7-13-21/h2-15,17,25,27H,16,18-19H2,1H3 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salerno
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b... |
J Med Chem 63: 9672-9694 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00816 BindingDB Entry DOI: 10.7270/Q2GF0Z2X |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50461837
(CHEMBL4226608)Show SMILES [#6]-[#8]-c1cc(-[#6]-[#7]-[#6](=O)-[#6]-[#8]-[#6](=O)\[#6]=[#6](/[#6])-[#6]-[#6]\[#6]=[#6](\[#6])-[#6])c(I)cc1-[#8] Show InChI InChI=1S/C20H26INO5/c1-13(2)6-5-7-14(3)8-20(25)27-12-19(24)22-11-15-9-18(26-4)17(23)10-16(15)21/h6,8-10,23H,5,7,11-12H2,1-4H3,(H,22,24)/b14-8+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ del Piemonte Orientale
Curated by ChEMBL
| Assay Description Antagonist activity at TRPV1 (unknown origin) expressed in human SH-SY5Y cells assessed as inhibition of capsaicin-induced calcium increase after 25 ... |
J Med Chem 61: 4436-4455 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00109 BindingDB Entry DOI: 10.7270/Q2PK0JSM |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50592164
(CHEMBL5208212)Show SMILES COC(=O)[C@H](Cc1ccc(O)c(O)c1)N(Cc1ccccc1)Cc1ccccc1 |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114435 BindingDB Entry DOI: 10.7270/Q2ZP4B36 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50592165
(CHEMBL5198707)Show SMILES COC(=O)[C@H](Cc1ccc(N)cc1)N(Cc1ccccc1)Cc1ccccc1 |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114435 BindingDB Entry DOI: 10.7270/Q2ZP4B36 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50592161
(CHEMBL5198220)Show SMILES COC(=O)[C@H](Cc1ccc(cc1)[N+]([O-])=O)N(Cc1ccccc1)Cc1ccccc1 |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114435 BindingDB Entry DOI: 10.7270/Q2ZP4B36 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50544531
(CHEMBL4648953)Show SMILES [H][C@@]12Cc3c([nH]c4ccccc34)[C@@H](N1C(=O)N(C2=O)c1cccc(c1)C(F)(F)F)c1ccc(F)cc1 |r| Show InChI InChI=1S/C26H17F4N3O2/c27-16-10-8-14(9-11-16)23-22-19(18-6-1-2-7-20(18)31-22)13-21-24(34)32(25(35)33(21)23)17-5-3-4-15(12-17)26(28,29)30/h1-12,21,23,31H,13H2/t21-,23-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salerno
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b... |
J Med Chem 63: 9672-9694 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00816 BindingDB Entry DOI: 10.7270/Q2GF0Z2X |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50592165
(CHEMBL5198707)Show SMILES COC(=O)[C@H](Cc1ccc(N)cc1)N(Cc1ccccc1)Cc1ccccc1 |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114435 BindingDB Entry DOI: 10.7270/Q2ZP4B36 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50592163
(CHEMBL5169807)Show SMILES COC(=O)[C@H](Cc1ccc(O)cc1)N(Cc1ccccc1)Cc1ccccc1 |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114435 BindingDB Entry DOI: 10.7270/Q2ZP4B36 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50592159
(CHEMBL5193429)Show SMILES COC(=O)[C@H](Cc1ccc(Cl)cc1)N(Cc1ccccc1)Cc1ccccc1 |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114435 BindingDB Entry DOI: 10.7270/Q2ZP4B36 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50592160
(CHEMBL5182352)Show SMILES COC(=O)[C@H](Cc1ccc(C)cc1)N(Cc1ccccc1)Cc1ccccc1 |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114435 BindingDB Entry DOI: 10.7270/Q2ZP4B36 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50592162
(CHEMBL5205458)Show SMILES COC(=O)[C@H](Cc1ccccc1)N(Cc1ccccc1)Cc1ccccc1 |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114435 BindingDB Entry DOI: 10.7270/Q2ZP4B36 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50544513
(CHEMBL4649088)Show SMILES [H][C@@]12Cc3c(CN1C(=O)[C@@H](Cc1ccccc1)NC2=O)[nH]c1ccccc31 |r| Show InChI InChI=1S/C21H19N3O2/c25-20-19-11-15-14-8-4-5-9-16(14)22-18(15)12-24(19)21(26)17(23-20)10-13-6-2-1-3-7-13/h1-9,17,19,22H,10-12H2,(H,23,25)/t17-,19+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salerno
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b... |
J Med Chem 63: 9672-9694 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00816 BindingDB Entry DOI: 10.7270/Q2GF0Z2X |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50133817
(4-(3-Chloro-pyridin-2-yl)-piperazine-1-carboxylic ...)Show SMILES CC(C)(C)c1ccc(NC(=O)N2CCN(CC2)c2ncccc2Cl)cc1 Show InChI InChI=1S/C20H25ClN4O/c1-20(2,3)15-6-8-16(9-7-15)23-19(26)25-13-11-24(12-14-25)18-17(21)5-4-10-22-18/h4-10H,11-14H2,1-3H3,(H,23,26) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 475 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salerno
Curated by ChEMBL
| Assay Description Antagonist activity at TRPM8 (unknown origin) assessed as reduction in menthol-induced calcium influx |
J Med Chem 61: 6140-6152 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00545 BindingDB Entry DOI: 10.7270/Q2FN18V3 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50592164
(CHEMBL5208212)Show SMILES COC(=O)[C@H](Cc1ccc(O)c(O)c1)N(Cc1ccccc1)Cc1ccccc1 |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 490 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114435 BindingDB Entry DOI: 10.7270/Q2ZP4B36 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50544523
(CHEMBL4647674)Show SMILES [H][C@@]12Cc3c([nH]c4ccccc34)[C@H](N1C(=O)N(Cc1ccc(F)cc1)C2=O)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C26H19ClFN3O2/c27-17-9-7-16(8-10-17)24-23-20(19-3-1-2-4-21(19)29-23)13-22-25(32)30(26(33)31(22)24)14-15-5-11-18(28)12-6-15/h1-12,22,24,29H,13-14H2/t22-,24+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salerno
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b... |
J Med Chem 63: 9672-9694 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00816 BindingDB Entry DOI: 10.7270/Q2GF0Z2X |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50465611
(CHEMBL4284808)Show InChI InChI=1S/C24H30N2/c1-3-9-20(10-4-1)18-26(19-21-11-5-2-6-12-21)16-15-22-17-25-24-14-8-7-13-23(22)24/h1,3-4,7-10,13-14,17,21,25H,2,5-6,11-12,15-16,18-19H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salerno
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced calcium flux incubated for 60 mins by Fluo-4 NW-d... |
J Med Chem 61: 6140-6152 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00545 BindingDB Entry DOI: 10.7270/Q2FN18V3 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50544521
(CHEMBL4634053)Show SMILES [H][C@@]12Cc3c([nH]c4ccccc34)[C@H](N1C(=O)N(Cc1ccc(C)cc1)C2=O)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C27H22ClN3O2/c1-16-6-8-17(9-7-16)15-30-26(32)23-14-21-20-4-2-3-5-22(20)29-24(21)25(31(23)27(30)33)18-10-12-19(28)13-11-18/h2-13,23,25,29H,14-15H2,1H3/t23-,25+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salerno
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b... |
J Med Chem 63: 9672-9694 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00816 BindingDB Entry DOI: 10.7270/Q2GF0Z2X |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50592157
(CHEMBL5193818)Show SMILES Oc1cc2C[C@H](N[C@H](c3ccc(F)cc3)c2cc1O)C(=O)NCc1ccc(F)cc1 |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 850 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114435 BindingDB Entry DOI: 10.7270/Q2ZP4B36 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50465615
(CHEMBL4282067)Show SMILES COC(=O)[C@@H](Cc1c[nH]c2ccccc12)N(Cc1ccccc1)Cc1ccccc1 |r| Show InChI InChI=1S/C26H26N2O2/c1-30-26(29)25(16-22-17-27-24-15-9-8-14-23(22)24)28(18-20-10-4-2-5-11-20)19-21-12-6-3-7-13-21/h2-15,17,25,27H,16,18-19H2,1H3/t25-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 865 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salerno
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced channel currents by whole cell patch clamp method |
J Med Chem 61: 6140-6152 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00545 BindingDB Entry DOI: 10.7270/Q2FN18V3 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50544501
(CHEMBL4647444)Show SMILES COC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1Cc1ccccc1)c1ccccc1 |r| Show InChI InChI=1S/C26H24N2O2/c1-30-26(29)23-16-21-20-14-8-9-15-22(20)27-24(21)25(19-12-6-3-7-13-19)28(23)17-18-10-4-2-5-11-18/h2-15,23,25,27H,16-17H2,1H3/t23-,25+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salerno
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b... |
J Med Chem 63: 9672-9694 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00816 BindingDB Entry DOI: 10.7270/Q2GF0Z2X |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50544503
(CHEMBL4644158)Show SMILES Fc1ccc(CNC(=O)[C@@H]2Cc3c(CN2)[nH]c2ccccc32)cc1 |r| Show InChI InChI=1S/C19H18FN3O/c20-13-7-5-12(6-8-13)10-22-19(24)17-9-15-14-3-1-2-4-16(14)23-18(15)11-21-17/h1-8,17,21,23H,9-11H2,(H,22,24)/t17-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salerno
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b... |
J Med Chem 63: 9672-9694 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00816 BindingDB Entry DOI: 10.7270/Q2GF0Z2X |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50461844
(CHEMBL4227926)Show InChI InChI=1S/C22H34INO5/c1-3-4-5-6-7-8-9-10-11-12-22(27)29-16-21(26)24-15-17-13-20(28-2)19(25)14-18(17)23/h13-14,25H,3-12,15-16H2,1-2H3,(H,24,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 930 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ del Piemonte Orientale
Curated by ChEMBL
| Assay Description Antagonist activity at TRPV1 (unknown origin) expressed in human SH-SY5Y cells assessed as inhibition of capsaicin-induced calcium increase after 25 ... |
J Med Chem 61: 4436-4455 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00109 BindingDB Entry DOI: 10.7270/Q2PK0JSM |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50544506
(CHEMBL4647464)Show SMILES COC(=O)CC[C@H]1N[C@@H](Cc2c1[nH]c1ccccc21)C(=O)NCc1ccc(F)cc1 |r| Show InChI InChI=1S/C23H24FN3O3/c1-30-21(28)11-10-19-22-17(16-4-2-3-5-18(16)27-22)12-20(26-19)23(29)25-13-14-6-8-15(24)9-7-14/h2-9,19-20,26-27H,10-13H2,1H3,(H,25,29)/t19-,20+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salerno
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b... |
J Med Chem 63: 9672-9694 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00816 BindingDB Entry DOI: 10.7270/Q2GF0Z2X |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50592155
(CHEMBL5203685)Show SMILES [H][C@@]12Cc3cc(O)c(O)cc3[C@H](N1C(=O)N(C2=O)c1cccc(c1)C(F)(F)F)c1ccc(F)cc1 |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114435 BindingDB Entry DOI: 10.7270/Q2ZP4B36 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50544515
(CHEMBL4645828)Show SMILES [H][C@@]12Cc3c([nH]c4ccccc34)[C@H](CC(C)C)N1C(=O)[C@H](Cc1ccccc1)NC2=O |r| Show InChI InChI=1S/C25H27N3O2/c1-15(2)12-21-23-18(17-10-6-7-11-19(17)26-23)14-22-24(29)27-20(25(30)28(21)22)13-16-8-4-3-5-9-16/h3-11,15,20-22,26H,12-14H2,1-2H3,(H,27,29)/t20-,21-,22-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salerno
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b... |
J Med Chem 63: 9672-9694 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00816 BindingDB Entry DOI: 10.7270/Q2GF0Z2X |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily V member 1
(Homo sapiens (Human)) | BDBM50461847
(CHEMBL4226335)Show InChI InChI=1S/C18H26INO5/c1-3-4-5-6-7-8-18(23)25-12-17(22)20-11-13-9-16(24-2)15(21)10-14(13)19/h9-10,21H,3-8,11-12H2,1-2H3,(H,20,22) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.34E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ del Piemonte Orientale
Curated by ChEMBL
| Assay Description Antagonist activity at TRPV1 (unknown origin) expressed in human SH-SY5Y cells assessed as inhibition of capsaicin-induced calcium increase after 25 ... |
J Med Chem 61: 4436-4455 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00109 BindingDB Entry DOI: 10.7270/Q2PK0JSM |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50544516
(CHEMBL4643039)Show SMILES [H][C@@]12Cc3c([nH]c4ccccc34)[C@H](N1C(=O)CNC2=O)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C20H16ClN3O2/c21-12-7-5-11(6-8-12)19-18-14(13-3-1-2-4-15(13)23-18)9-16-20(26)22-10-17(25)24(16)19/h1-8,16,19,23H,9-10H2,(H,22,26)/t16-,19+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salerno
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b... |
J Med Chem 63: 9672-9694 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00816 BindingDB Entry DOI: 10.7270/Q2GF0Z2X |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50465618
(CHEMBL4291622)Show SMILES O=C(CN1CCc2c([nH]c3ccccc23)C1c1ccccc1)c1ccccc1 Show InChI InChI=1S/C25H22N2O/c28-23(18-9-3-1-4-10-18)17-27-16-15-21-20-13-7-8-14-22(20)26-24(21)25(27)19-11-5-2-6-12-19/h1-14,25-26H,15-17H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salerno
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced calcium flux incubated for 60 mins by Fluo-4 NW-d... |
J Med Chem 61: 6140-6152 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00545 BindingDB Entry DOI: 10.7270/Q2FN18V3 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50544512
(CHEMBL229543)Show SMILES [H][C@@]12Cc3c(CN1C(=O)[C@H](Cc1ccccc1)NC2=O)[nH]c1ccccc31 Show InChI InChI=1S/C21H19N3O2/c25-20-19-11-15-14-8-4-5-9-16(14)22-18(15)12-24(19)21(26)17(23-20)10-13-6-2-1-3-7-13/h1-9,17,19,22H,10-12H2,(H,23,25)/t17-,19-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salerno
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b... |
J Med Chem 63: 9672-9694 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00816 BindingDB Entry DOI: 10.7270/Q2GF0Z2X |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50544502
(CHEMBL4634045)Show SMILES COC(=O)[C@@H]1Cc2c([nH]c3ccccc23)[C@@H](N1Cc1ccccc1)c1ccccc1 |r| Show InChI InChI=1S/C26H24N2O2/c1-30-26(29)23-16-21-20-14-8-9-15-22(20)27-24(21)25(19-12-6-3-7-13-19)28(23)17-18-10-4-2-5-11-18/h2-15,23,25,27H,16-17H2,1H3/t23-,25-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salerno
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b... |
J Med Chem 63: 9672-9694 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00816 BindingDB Entry DOI: 10.7270/Q2GF0Z2X |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50592153
(CHEMBL5176697)Show SMILES [H][C@@]12Cc3cc(O)c(O)cc3[C@H](N1C(=O)N(Cc1ccc(F)cc1)C2=O)c1ccc(F)cc1 |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114435 BindingDB Entry DOI: 10.7270/Q2ZP4B36 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50544517
(CHEMBL4641209)Show SMILES [H][C@@]12Cc3c([nH]c4ccccc34)[C@@H](N1C(=O)CNC2=O)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C20H16ClN3O2/c21-12-7-5-11(6-8-12)19-18-14(13-3-1-2-4-15(13)23-18)9-16-20(26)22-10-17(25)24(16)19/h1-8,16,19,23H,9-10H2,(H,22,26)/t16-,19-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salerno
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b... |
J Med Chem 63: 9672-9694 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00816 BindingDB Entry DOI: 10.7270/Q2GF0Z2X |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50465619
(CHEMBL4287812)Show SMILES C(Cc1c[nH]c2ccc(OCc3ccccc3)cc12)N(Cc1ccccc1)Cc1ccccc1 Show InChI InChI=1S/C31H30N2O/c1-4-10-25(11-5-1)22-33(23-26-12-6-2-7-13-26)19-18-28-21-32-31-17-16-29(20-30(28)31)34-24-27-14-8-3-9-15-27/h1-17,20-21,32H,18-19,22-24H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salerno
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced calcium flux incubated for 60 mins by Fluo-4 NW-d... |
J Med Chem 61: 6140-6152 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00545 BindingDB Entry DOI: 10.7270/Q2FN18V3 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50592156
(CHEMBL5206192)Show SMILES [H][C@]12Cc3cc(O)c(O)cc3[C@@H](N1C(=O)N(C2=O)c1cccc(c1)C(F)(F)F)c1ccc(F)cc1 |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114435 BindingDB Entry DOI: 10.7270/Q2ZP4B36 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50592154
(CHEMBL5173566)Show SMILES [H][C@]12Cc3cc(O)c(O)cc3[C@@H](N1C(=O)N(Cc1ccc(F)cc1)C2=O)c1ccc(F)cc1 |r| | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114435 BindingDB Entry DOI: 10.7270/Q2ZP4B36 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50465614
(CHEMBL4292679)Show SMILES [O-][N+](=O)c1ccc(Sc2[nH]c3ccccc3c2CCN(Cc2ccccc2)Cc2ccccc2)c(c1)[N+]([O-])=O Show InChI InChI=1S/C30H26N4O4S/c35-33(36)24-15-16-29(28(19-24)34(37)38)39-30-26(25-13-7-8-14-27(25)31-30)17-18-32(20-22-9-3-1-4-10-22)21-23-11-5-2-6-12-23/h1-16,19,31H,17-18,20-21H2 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salerno
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as reduction in menthol-induced calcium flux incubated for 60 mins by Fluo-4 NW-d... |
J Med Chem 61: 6140-6152 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00545 BindingDB Entry DOI: 10.7270/Q2FN18V3 |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50544522
(CHEMBL4637725)Show SMILES [H][C@]12Cc3c([nH]c4ccccc34)[C@@H](N1C(=O)N(Cc1ccc(C)cc1)C2=O)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C27H22ClN3O2/c1-16-6-8-17(9-7-16)15-30-26(32)23-14-21-20-4-2-3-5-22(20)29-24(21)25(31(23)27(30)33)18-10-12-19(28)13-11-18/h2-13,23,25,29H,14-15H2,1H3/t23-,25+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salerno
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b... |
J Med Chem 63: 9672-9694 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00816 BindingDB Entry DOI: 10.7270/Q2GF0Z2X |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50544519
(CHEMBL4640958)Show SMILES [H][C@@]12Cc3c([nH]c4ccccc34)[C@@H](CC(C)C)N1C(=O)N(Cc1ccc(OC)cc1)C2=O |r| Show InChI InChI=1S/C25H27N3O3/c1-15(2)12-21-23-19(18-6-4-5-7-20(18)26-23)13-22-24(29)27(25(30)28(21)22)14-16-8-10-17(31-3)11-9-16/h4-11,15,21-22,26H,12-14H2,1-3H3/t21-,22+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salerno
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b... |
J Med Chem 63: 9672-9694 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00816 BindingDB Entry DOI: 10.7270/Q2GF0Z2X |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50544529
(CHEMBL4640675)Show SMILES [H][C@@]12Cc3c([nH]c4ccccc34)[C@H](N1C(=O)N(C2=O)c1cccc(c1)C(F)(F)F)c1ccc(F)cc1 |r| Show InChI InChI=1S/C26H17F4N3O2/c27-16-10-8-14(9-11-16)23-22-19(18-6-1-2-7-20(18)31-22)13-21-24(34)32(25(35)33(21)23)17-5-3-4-15(12-17)26(28,29)30/h1-12,21,23,31H,13H2/t21-,23+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salerno
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b... |
J Med Chem 63: 9672-9694 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00816 BindingDB Entry DOI: 10.7270/Q2GF0Z2X |
More data for this Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50544507
(CHEMBL4637346)Show SMILES COC(=O)CC[C@@H]1N[C@@H](Cc2c1[nH]c1ccccc21)C(=O)NCc1ccc(F)cc1 |r| Show InChI InChI=1S/C23H24FN3O3/c1-30-21(28)11-10-19-22-17(16-4-2-3-5-18(16)27-22)12-20(26-19)23(29)25-13-14-6-8-15(24)9-7-14/h2-9,19-20,26-27H,10-13H2,1H3,(H,25,29)/t19-,20-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salerno
Curated by ChEMBL
| Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b... |
J Med Chem 63: 9672-9694 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00816 BindingDB Entry DOI: 10.7270/Q2GF0Z2X |
More data for this Ligand-Target Pair | |