Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Prostaglandin G/H synthase 1 (Ovis aries (Sheep)) | BDBM50376383![]() (CHEMBL259972) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari"A.Moro" Curated by ChEMBL | Assay Description Inhibition of ovine COX-1 assessed as inhibition of PGH2 production using arachidonic acid as substrate by TMPD oxidation based colorimetric assay | Eur J Med Chem 94: 252-64 (2015) Article DOI: 10.1016/j.ejmech.2015.02.049 BindingDB Entry DOI: 10.7270/Q2416ZRX | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Prostaglandin G/H synthase 1 (Homo sapiens (Human)) | BDBM50084631![]() (CHEMBL3427203) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari"A.Moro" Curated by ChEMBL | Assay Description Inhibition of LPS-induced COX1 in human whole blood assessed as reduction in TXB2 levels by radioimmunoassay | Eur J Med Chem 94: 252-64 (2015) Article DOI: 10.1016/j.ejmech.2015.02.049 BindingDB Entry DOI: 10.7270/Q2416ZRX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 1 (Ovis aries (Sheep)) | BDBM13065![]() (5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluor...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari"A.Moro" Curated by ChEMBL | Assay Description Inhibition of ovine COX-1 assessed as inhibition of PGH2 production using arachidonic acid as substrate by TMPD oxidation based colorimetric assay | Eur J Med Chem 94: 252-64 (2015) Article DOI: 10.1016/j.ejmech.2015.02.049 BindingDB Entry DOI: 10.7270/Q2416ZRX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 1 (Ovis aries (Sheep)) | BDBM50376383![]() (CHEMBL259972) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Thomas Jefferson University Curated by ChEMBL | Assay Description Inhibition of ovine COX1 catalytic activity using arachidonic acid as substrate preincubated for 5 mins followed by substrate and hemin addition meas... | Eur J Med Chem 138: 661-668 (2017) Article DOI: 10.1016/j.ejmech.2017.06.045 BindingDB Entry DOI: 10.7270/Q2D2215F | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Prostaglandin G/H synthase 2 (Ovis aries (Sheep)) | BDBM50376383![]() (CHEMBL259972) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari"A.Moro" Curated by ChEMBL | Assay Description Inhibition of ovine COX-2 assessed as inhibition of PGH2 production using arachidonic acid as substrate by TMPD oxidation based colorimetric assay | Eur J Med Chem 94: 252-64 (2015) Article DOI: 10.1016/j.ejmech.2015.02.049 BindingDB Entry DOI: 10.7270/Q2416ZRX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 1 (Homo sapiens (Human)) | BDBM50153040![]() (3-(5-Chloro-furan-2-yl)-5-methyl-4-phenyl-isoxazol...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari"A.Moro" Curated by ChEMBL | Assay Description Inhibition of LPS-induced COX1 in human whole blood assessed as reduction in TXB2 levels by radioimmunoassay | Eur J Med Chem 94: 252-64 (2015) Article DOI: 10.1016/j.ejmech.2015.02.049 BindingDB Entry DOI: 10.7270/Q2416ZRX | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Prostaglandin G/H synthase 1 (Ovis aries (Sheep)) | BDBM50084649![]() (CHEMBL3114664) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | CHEMBL MMDB PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari"A.Moro" Curated by ChEMBL | Assay Description Inhibition of ovine COX-1 assessed as inhibition of PGH2 production using arachidonic acid as substrate by TMPD oxidation based colorimetric assay | Eur J Med Chem 94: 252-64 (2015) Article DOI: 10.1016/j.ejmech.2015.02.049 BindingDB Entry DOI: 10.7270/Q2416ZRX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 1 (Ovis aries (Sheep)) | BDBM50084642![]() (CHEMBL3427198) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari"A.Moro" Curated by ChEMBL | Assay Description Inhibition of ovine COX-1 assessed as inhibition of PGH2 production using arachidonic acid as substrate by TMPD oxidation based colorimetric assay | Eur J Med Chem 94: 252-64 (2015) Article DOI: 10.1016/j.ejmech.2015.02.049 BindingDB Entry DOI: 10.7270/Q2416ZRX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 2 (Homo sapiens (Human)) | BDBM50084631![]() (CHEMBL3427203) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari"A.Moro" Curated by ChEMBL | Assay Description Inhibition of LPS-induced COX2 in human whole blood assessed as reduction in PGH2 levels by radioimmunoassay | Eur J Med Chem 94: 252-64 (2015) Article DOI: 10.1016/j.ejmech.2015.02.049 BindingDB Entry DOI: 10.7270/Q2416ZRX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 1 (Ovis aries (Sheep)) | BDBM50084632![]() (CHEMBL3427204) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari"A.Moro" Curated by ChEMBL | Assay Description Inhibition of ovine COX-1 assessed as inhibition of PGH2 production using arachidonic acid as substrate by TMPD oxidation based colorimetric assay | Eur J Med Chem 94: 252-64 (2015) Article DOI: 10.1016/j.ejmech.2015.02.049 BindingDB Entry DOI: 10.7270/Q2416ZRX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 1 (Ovis aries (Sheep)) | BDBM50084645![]() (CHEMBL3114671) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari"A.Moro" Curated by ChEMBL | Assay Description Inhibition of ovine COX-1 assessed as inhibition of PGH2 production using arachidonic acid as substrate by TMPD oxidation based colorimetric assay | Eur J Med Chem 94: 252-64 (2015) Article DOI: 10.1016/j.ejmech.2015.02.049 BindingDB Entry DOI: 10.7270/Q2416ZRX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 1 (Ovis aries (Sheep)) | BDBM50084643![]() (CHEMBL3427197) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari"A.Moro" Curated by ChEMBL | Assay Description Inhibition of ovine COX-1 assessed as inhibition of PGH2 production using arachidonic acid as substrate by TMPD oxidation based colorimetric assay | Eur J Med Chem 94: 252-64 (2015) Article DOI: 10.1016/j.ejmech.2015.02.049 BindingDB Entry DOI: 10.7270/Q2416ZRX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 1 (Ovis aries (Sheep)) | BDBM50153040![]() (3-(5-Chloro-furan-2-yl)-5-methyl-4-phenyl-isoxazol...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 1.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Thomas Jefferson University Curated by ChEMBL | Assay Description Inhibition of ovine COX1 catalytic activity using arachidonic acid as substrate preincubated for 5 mins followed by substrate and hemin addition meas... | Eur J Med Chem 138: 661-668 (2017) Article DOI: 10.1016/j.ejmech.2017.06.045 BindingDB Entry DOI: 10.7270/Q2D2215F | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Prostaglandin G/H synthase 1 (Ovis aries (Sheep)) | BDBM50084639![]() (CHEMBL3427202) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | CHEMBL MMDB PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari"A.Moro" Curated by ChEMBL | Assay Description Inhibition of ovine COX-1 assessed as inhibition of PGH2 production using arachidonic acid as substrate by TMPD oxidation based colorimetric assay | Eur J Med Chem 94: 252-64 (2015) Article DOI: 10.1016/j.ejmech.2015.02.049 BindingDB Entry DOI: 10.7270/Q2416ZRX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 1 (Ovis aries (Sheep)) | BDBM50084644![]() (CHEMBL3114659) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari"A.Moro" Curated by ChEMBL | Assay Description Inhibition of ovine COX-1 assessed as inhibition of PGH2 production using arachidonic acid as substrate by TMPD oxidation based colorimetric assay | Eur J Med Chem 94: 252-64 (2015) Article DOI: 10.1016/j.ejmech.2015.02.049 BindingDB Entry DOI: 10.7270/Q2416ZRX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 1 (Ovis aries (Sheep)) | BDBM50084647![]() (CHEMBL3114661) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari"A.Moro" Curated by ChEMBL | Assay Description Inhibition of ovine COX-1 assessed as inhibition of PGH2 production using arachidonic acid as substrate by TMPD oxidation based colorimetric assay | Eur J Med Chem 94: 252-64 (2015) Article DOI: 10.1016/j.ejmech.2015.02.049 BindingDB Entry DOI: 10.7270/Q2416ZRX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 1 (Ovis aries (Sheep)) | BDBM50153040![]() (3-(5-Chloro-furan-2-yl)-5-methyl-4-phenyl-isoxazol...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 3.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari"A.Moro" Curated by ChEMBL | Assay Description Inhibition of ovine COX-1 assessed as inhibition of PGH2 production using arachidonic acid as substrate by TMPD oxidation based colorimetric assay | Eur J Med Chem 94: 252-64 (2015) Article DOI: 10.1016/j.ejmech.2015.02.049 BindingDB Entry DOI: 10.7270/Q2416ZRX | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Prostaglandin G/H synthase 2 (Ovis aries (Sheep)) | BDBM50376383![]() (CHEMBL259972) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Thomas Jefferson University Curated by ChEMBL | Assay Description Inhibition of recombinant ovine COX2 catalytic activity using arachidonic acid as substrate preincubated for 5 mins followed by substrate and hemin a... | Eur J Med Chem 138: 661-668 (2017) Article DOI: 10.1016/j.ejmech.2017.06.045 BindingDB Entry DOI: 10.7270/Q2D2215F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 2 (Ovis aries (Sheep)) | BDBM50153040![]() (3-(5-Chloro-furan-2-yl)-5-methyl-4-phenyl-isoxazol...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Thomas Jefferson University Curated by ChEMBL | Assay Description Inhibition of recombinant ovine COX2 catalytic activity using arachidonic acid as substrate preincubated for 5 mins followed by substrate and hemin a... | Eur J Med Chem 138: 661-668 (2017) Article DOI: 10.1016/j.ejmech.2017.06.045 BindingDB Entry DOI: 10.7270/Q2D2215F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 2 (Ovis aries (Sheep)) | BDBM13065![]() (5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluor...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 7.49E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari"A.Moro" Curated by ChEMBL | Assay Description Inhibition of ovine COX-2 assessed as inhibition of PGH2 production using arachidonic acid as substrate by TMPD oxidation based colorimetric assay | Eur J Med Chem 94: 252-64 (2015) Article DOI: 10.1016/j.ejmech.2015.02.049 BindingDB Entry DOI: 10.7270/Q2416ZRX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prostaglandin G/H synthase 2 (Homo sapiens (Human)) | BDBM50153040![]() (3-(5-Chloro-furan-2-yl)-5-methyl-4-phenyl-isoxazol...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Bari"A.Moro" Curated by ChEMBL | Assay Description Inhibition of LPS-induced COX2 in human whole blood assessed as reduction in PGH2 levels by radioimmunoassay | Eur J Med Chem 94: 252-64 (2015) Article DOI: 10.1016/j.ejmech.2015.02.049 BindingDB Entry DOI: 10.7270/Q2416ZRX | |||||||||||
More data for this Ligand-Target Pair |