Compile Data Set for Download or QSAR

Found 235 hits with Last Name = 'ravji' and Initial = 'a'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50521692 (CHEMBL4441013) Show SMILES CS(=O)(=O)Nc1cccc(c1)-n1c2cc(ccc2cc2c1nc(=O)n(-c1ccc(Cl)cc1)c2=O)C#N Show InChI InChI=1S/C25H16ClN5O4S/c1-36(34,35)29-18-3-2-4-20(13-18)30-22-11-15(14-27)5-6-16(22)12-21-23(30)28-25(33)31(24(21)32)19-9-7-17(26)8-10-19/h2-13,29H,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.10	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...				J Med Chem 62: 4669-4682 (2019) Article DOI: 10.1021/acs.jmedchem.9b00274 BindingDB Entry DOI: 10.7270/Q2F1934F
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50521699 (CHEMBL4572376) Show SMILES CS(=O)(=O)Nc1ccc(cc1)-n1c2cc(ccc2cc2c1nc(=O)n(-c1ccc(Cl)cc1)c2=O)C#N Show InChI InChI=1S/C25H16ClN5O4S/c1-36(34,35)29-18-6-10-19(11-7-18)30-22-12-15(14-27)2-3-16(22)13-21-23(30)28-25(33)31(24(21)32)20-8-4-17(26)5-9-20/h2-13,29H,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.5	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...				J Med Chem 62: 4669-4682 (2019) Article DOI: 10.1021/acs.jmedchem.9b00274 BindingDB Entry DOI: 10.7270/Q2F1934F
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50521689 (CHEMBL4436202) Show SMILES Oc1cccc(c1)-n1c2cc(ccc2cc2c1nc(=O)n(-c1ccc(Cl)cc1)c2=O)C#N Show InChI InChI=1S/C24H13ClN4O3/c25-16-6-8-17(9-7-16)29-23(31)20-11-15-5-4-14(13-26)10-21(15)28(22(20)27-24(29)32)18-2-1-3-19(30)12-18/h1-12,30H	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.30	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...				J Med Chem 62: 4669-4682 (2019) Article DOI: 10.1021/acs.jmedchem.9b00274 BindingDB Entry DOI: 10.7270/Q2F1934F
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50521691 (CHEMBL4587441) Show SMILES Oc1cccc(c1)-n1c2cc(ccc2cc2c1nc(=O)n(-c1ccc(Cl)c(Cl)c1)c2=O)C#N Show InChI InChI=1S/C24H12Cl2N4O3/c25-19-7-6-16(11-20(19)26)30-23(32)18-9-14-5-4-13(12-27)8-21(14)29(22(18)28-24(30)33)15-2-1-3-17(31)10-15/h1-11,31H	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...				J Med Chem 62: 4669-4682 (2019) Article DOI: 10.1021/acs.jmedchem.9b00274 BindingDB Entry DOI: 10.7270/Q2F1934F
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50521690 (CHEMBL4520052) Show SMILES Oc1cccc(c1)-n1c2cc(ccc2cc2c1nc(=O)n(-c1cccc(Cl)c1)c2=O)C#N Show InChI InChI=1S/C24H13ClN4O3/c25-16-3-1-4-17(11-16)29-23(31)20-10-15-8-7-14(13-26)9-21(15)28(22(20)27-24(29)32)18-5-2-6-19(30)12-18/h1-12,30H	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...				J Med Chem 62: 4669-4682 (2019) Article DOI: 10.1021/acs.jmedchem.9b00274 BindingDB Entry DOI: 10.7270/Q2F1934F
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50521697 (CHEMBL4468174) Show SMILES Oc1ccc(cc1)-n1c2cc(ccc2cc2c1nc(=O)n(-c1ccc(Cl)cc1)c2=O)C#N Show InChI InChI=1S/C24H13ClN4O3/c25-16-3-5-18(6-4-16)29-23(31)20-12-15-2-1-14(13-26)11-21(15)28(22(20)27-24(29)32)17-7-9-19(30)10-8-17/h1-12,30H	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...				J Med Chem 62: 4669-4682 (2019) Article DOI: 10.1021/acs.jmedchem.9b00274 BindingDB Entry DOI: 10.7270/Q2F1934F
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50521687 (CHEMBL4560735) Show SMILES Oc1ccc(cc1)-n1c2cc(ccc2cc2c1nc(=O)n(-c1ccccc1)c2=O)C#N Show InChI InChI=1S/C24H14N4O3/c25-14-15-6-7-16-13-20-22(27(21(16)12-15)18-8-10-19(29)11-9-18)26-24(31)28(23(20)30)17-4-2-1-3-5-17/h1-13,29H	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...				J Med Chem 62: 4669-4682 (2019) Article DOI: 10.1021/acs.jmedchem.9b00274 BindingDB Entry DOI: 10.7270/Q2F1934F
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50521698 (CHEMBL4555612) Show SMILES NC(=O)c1cccc(c1)-n1c(=O)nc2n(-c3ccc(O)cc3)c3cc(ccc3cc2c1=O)C#N Show InChI InChI=1S/C25H15N5O4/c26-13-14-4-5-15-12-20-23(29(21(15)10-14)17-6-8-19(31)9-7-17)28-25(34)30(24(20)33)18-3-1-2-16(11-18)22(27)32/h1-12,31H,(H2,27,32)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...				J Med Chem 62: 4669-4682 (2019) Article DOI: 10.1021/acs.jmedchem.9b00274 BindingDB Entry DOI: 10.7270/Q2F1934F
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50521678 (CHEMBL4521151) Show SMILES COC(=O)c1cccc(c1)-n1c(=O)nc2n(-c3ccc(O)cc3)c3cc(ccc3cc2c1=O)C#N Show InChI InChI=1S/C26H16N4O5/c1-35-25(33)17-3-2-4-19(12-17)30-24(32)21-13-16-6-5-15(14-27)11-22(16)29(23(21)28-26(30)34)18-7-9-20(31)10-8-18/h2-13,31H,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...				J Med Chem 62: 4669-4682 (2019) Article DOI: 10.1021/acs.jmedchem.9b00274 BindingDB Entry DOI: 10.7270/Q2F1934F
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50438848 (CHEMBL2420480) Show SMILES O=c1nc2n(-c3cccc(c3)-c3nnn[nH]3)c3cc(ccc3cc2c(=O)[nH]1)C#N Show InChI InChI=1S/C19H10N8O2/c20-9-10-4-5-11-8-14-17(21-19(29)22-18(14)28)27(15(11)6-10)13-3-1-2-12(7-13)16-23-25-26-24-16/h1-8H,(H,22,28,29)(H,23,24,25,26)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...				J Med Chem 62: 4669-4682 (2019) Article DOI: 10.1021/acs.jmedchem.9b00274 BindingDB Entry DOI: 10.7270/Q2F1934F
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50438864 (CHEMBL2420507) Show SMILES Oc1cccc(c1)-n1c2cc(ccc2cc2c1nc(=O)[nH]c2=O)C#N Show InChI InChI=1S/C18H10N4O3/c19-9-10-4-5-11-7-14-16(20-18(25)21-17(14)24)22(15(11)6-10)12-2-1-3-13(23)8-12/h1-8,23H,(H,21,24,25)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...				J Med Chem 62: 4669-4682 (2019) Article DOI: 10.1021/acs.jmedchem.9b00274 BindingDB Entry DOI: 10.7270/Q2F1934F
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50521701 (CHEMBL4457155) Show SMILES Oc1ccc(cc1)-n1c2cc(ccc2cc2c1nc(=O)n(-c1ccc(Br)cc1)c2=O)C#N Show InChI InChI=1S/C24H13BrN4O3/c25-16-3-5-18(6-4-16)29-23(31)20-12-15-2-1-14(13-26)11-21(15)28(22(20)27-24(29)32)17-7-9-19(30)10-8-17/h1-12,30H	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...				J Med Chem 62: 4669-4682 (2019) Article DOI: 10.1021/acs.jmedchem.9b00274 BindingDB Entry DOI: 10.7270/Q2F1934F
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50521688 (CHEMBL4546104) Show SMILES Oc1ccc(cc1)-n1c2cc(ccc2cc2c1nc(=O)n(-c1ccc(F)cc1)c2=O)C#N Show InChI InChI=1S/C24H13FN4O3/c25-16-3-5-18(6-4-16)29-23(31)20-12-15-2-1-14(13-26)11-21(15)28(22(20)27-24(29)32)17-7-9-19(30)10-8-17/h1-12,30H	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...				J Med Chem 62: 4669-4682 (2019) Article DOI: 10.1021/acs.jmedchem.9b00274 BindingDB Entry DOI: 10.7270/Q2F1934F
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50521702 (CHEMBL4518508) Show SMILES OC(=O)c1cccc(COc2ccc(cc2)-n2c3cc(ccc3cc3c2nc(=O)[nH]c3=O)C#N)c1 Show InChI InChI=1S/C26H16N4O5/c27-13-15-4-5-17-12-21-23(28-26(34)29-24(21)31)30(22(17)11-15)19-6-8-20(9-7-19)35-14-16-2-1-3-18(10-16)25(32)33/h1-12H,14H2,(H,32,33)(H,29,31,34)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...				J Med Chem 62: 4669-4682 (2019) Article DOI: 10.1021/acs.jmedchem.9b00274 BindingDB Entry DOI: 10.7270/Q2F1934F
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50438863 (10-(4-Hydroxyphenyl)-2,4-dioxo-pyrimido[4,5-b]quin...) Show SMILES Oc1ccc(cc1)-n1c2cc(ccc2cc2c1nc(=O)[nH]c2=O)C#N Show InChI InChI=1S/C18H10N4O3/c19-9-10-1-2-11-8-14-16(20-18(25)21-17(14)24)22(15(11)7-10)12-3-5-13(23)6-4-12/h1-8,23H,(H,21,24,25)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...				J Med Chem 62: 4669-4682 (2019) Article DOI: 10.1021/acs.jmedchem.9b00274 BindingDB Entry DOI: 10.7270/Q2F1934F
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50521683 (CHEMBL4576353) Show SMILES COC(=O)c1cccc(COc2ccc(cc2)-n2c3cc(ccc3cc3c2nc(=O)[nH]c3=O)C#N)c1 Show InChI InChI=1S/C27H18N4O5/c1-35-26(33)19-4-2-3-17(11-19)15-36-21-9-7-20(8-10-21)31-23-12-16(14-28)5-6-18(23)13-22-24(31)29-27(34)30-25(22)32/h2-13H,15H2,1H3,(H,30,32,34)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...				J Med Chem 62: 4669-4682 (2019) Article DOI: 10.1021/acs.jmedchem.9b00274 BindingDB Entry DOI: 10.7270/Q2F1934F
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50521686 (CHEMBL4557001) Show SMILES OC(=O)c1cccc(Oc2ccc(cc2)-n2c3cc(ccc3cc3c2nc(=O)[nH]c3=O)C#N)c1 Show InChI InChI=1S/C25H14N4O5/c26-13-14-4-5-15-12-20-22(27-25(33)28-23(20)30)29(21(15)10-14)17-6-8-18(9-7-17)34-19-3-1-2-16(11-19)24(31)32/h1-12H,(H,31,32)(H,28,30,33)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...				J Med Chem 62: 4669-4682 (2019) Article DOI: 10.1021/acs.jmedchem.9b00274 BindingDB Entry DOI: 10.7270/Q2F1934F
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50521681 (CHEMBL4464179) Show SMILES O=c1nc2n(-c3ccc(OCc4ccccc4)cc3)c3cc(ccc3cc2c(=O)[nH]1)C#N Show InChI InChI=1S/C25H16N4O3/c26-14-17-6-7-18-13-21-23(27-25(31)28-24(21)30)29(22(18)12-17)19-8-10-20(11-9-19)32-15-16-4-2-1-3-5-16/h1-13H,15H2,(H,28,30,31)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...				J Med Chem 62: 4669-4682 (2019) Article DOI: 10.1021/acs.jmedchem.9b00274 BindingDB Entry DOI: 10.7270/Q2F1934F
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50521693 (CHEMBL4471861) Show SMILES Clc1ccc(cc1)-n1c(=O)nc2n(-c3ccccc3)c3cc(ccc3cc2c1=O)C#N Show InChI InChI=1S/C24H13ClN4O2/c25-17-8-10-19(11-9-17)29-23(30)20-13-16-7-6-15(14-26)12-21(16)28(22(20)27-24(29)31)18-4-2-1-3-5-18/h1-13H	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...				J Med Chem 62: 4669-4682 (2019) Article DOI: 10.1021/acs.jmedchem.9b00274 BindingDB Entry DOI: 10.7270/Q2F1934F
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50521703 (CHEMBL4536546) Show SMILES O=c1nc2n(-c3cccc(Oc4ccccc4)c3)c3cc(ccc3cc2c(=O)[nH]1)C#N Show InChI InChI=1S/C24H14N4O3/c25-14-15-9-10-16-12-20-22(26-24(30)27-23(20)29)28(21(16)11-15)17-5-4-8-19(13-17)31-18-6-2-1-3-7-18/h1-13H,(H,27,29,30)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...				J Med Chem 62: 4669-4682 (2019) Article DOI: 10.1021/acs.jmedchem.9b00274 BindingDB Entry DOI: 10.7270/Q2F1934F
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50521680 (CHEMBL4444838) Show SMILES Cn1c(=O)nc2n(-c3ccc(O)cc3)c3cc(ccc3cc2c1=O)C#N Show InChI InChI=1S/C19H12N4O3/c1-22-18(25)15-9-12-3-2-11(10-20)8-16(12)23(17(15)21-19(22)26)13-4-6-14(24)7-5-13/h2-9,24H,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...				J Med Chem 62: 4669-4682 (2019) Article DOI: 10.1021/acs.jmedchem.9b00274 BindingDB Entry DOI: 10.7270/Q2F1934F
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50521677 (CHEMBL4590491) Show SMILES O=c1nc2n(-c3cccc(OCc4ccccc4)c3)c3cc(ccc3cc2c(=O)[nH]1)C#N Show InChI InChI=1S/C25H16N4O3/c26-14-17-9-10-18-12-21-23(27-25(31)28-24(21)30)29(22(18)11-17)19-7-4-8-20(13-19)32-15-16-5-2-1-3-6-16/h1-13H,15H2,(H,28,30,31)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...				J Med Chem 62: 4669-4682 (2019) Article DOI: 10.1021/acs.jmedchem.9b00274 BindingDB Entry DOI: 10.7270/Q2F1934F
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50438865 (2,4-Dioxo-10-phenyl-pyrimido[4,5-b]quinoline-8-car...) Show SMILES O=c1nc2n(-c3ccccc3)c3cc(ccc3cc2c(=O)[nH]1)C#N Show InChI InChI=1S/C18H10N4O2/c19-10-11-6-7-12-9-14-16(20-18(24)21-17(14)23)22(15(12)8-11)13-4-2-1-3-5-13/h1-9H,(H,21,23,24)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	640	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...				J Med Chem 62: 4669-4682 (2019) Article DOI: 10.1021/acs.jmedchem.9b00274 BindingDB Entry DOI: 10.7270/Q2F1934F
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50521679 (CHEMBL4470162) Show SMILES FC(F)Oc1ccc(cc1)-n1c2cc(ccc2cc2c1nc(=O)[nH]c2=O)C#N Show InChI InChI=1S/C19H10F2N4O3/c20-18(21)28-13-5-3-12(4-6-13)25-15-7-10(9-22)1-2-11(15)8-14-16(25)23-19(27)24-17(14)26/h1-8,18H,(H,24,26,27)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	880	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...				J Med Chem 62: 4669-4682 (2019) Article DOI: 10.1021/acs.jmedchem.9b00274 BindingDB Entry DOI: 10.7270/Q2F1934F
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50521696 (CHEMBL4585923) Show SMILES COC(=O)c1cccc(Oc2ccc(cc2)-n2c3cc(ccc3cc3c2nc(=O)[nH]c3=O)C#N)c1 Show InChI InChI=1S/C26H16N4O5/c1-34-25(32)17-3-2-4-20(12-17)35-19-9-7-18(8-10-19)30-22-11-15(14-27)5-6-16(22)13-21-23(30)28-26(33)29-24(21)31/h2-13H,1H3,(H,29,31,33)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	930	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...				J Med Chem 62: 4669-4682 (2019) Article DOI: 10.1021/acs.jmedchem.9b00274 BindingDB Entry DOI: 10.7270/Q2F1934F
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50521694 (CHEMBL4470609) Show SMILES O=c1nc2n(-c3ccc4OCOc4c3)c3cc(ccc3cc2c(=O)[nH]1)C#N Show InChI InChI=1S/C19H10N4O4/c20-8-10-1-2-11-6-13-17(21-19(25)22-18(13)24)23(14(11)5-10)12-3-4-15-16(7-12)27-9-26-15/h1-7H,9H2,(H,22,24,25)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	960	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...				J Med Chem 62: 4669-4682 (2019) Article DOI: 10.1021/acs.jmedchem.9b00274 BindingDB Entry DOI: 10.7270/Q2F1934F
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50521695 (CHEMBL4473892) Show SMILES Clc1cccc(COc2ccc(cc2)-n2c3cc(ccc3cc3c2nc(=O)[nH]c3=O)C#N)c1 Show InChI InChI=1S/C25H15ClN4O3/c26-18-3-1-2-16(10-18)14-33-20-8-6-19(7-9-20)30-22-11-15(13-27)4-5-17(22)12-21-23(30)28-25(32)29-24(21)31/h1-12H,14H2,(H,29,31,32)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	990	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...				J Med Chem 62: 4669-4682 (2019) Article DOI: 10.1021/acs.jmedchem.9b00274 BindingDB Entry DOI: 10.7270/Q2F1934F
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50237810 (CHEMBL4061238) Show SMILES COc1cnc-2c(c1)C(=O)c1c-2n(CCCN2CCC(N)CC2)c(=O)c2cc(ccc12)[N+]([O-])=O Show InChI InChI=1S/C24H25N5O5/c1-34-16-12-19-21(26-13-16)22-20(23(19)30)17-4-3-15(29(32)33)11-18(17)24(31)28(22)8-2-7-27-9-5-14(25)6-10-27/h3-4,11-14H,2,5-10,25H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of recombinant human Tdp2 assessed as decrease in alpha 32P-cordycepin-3'-labeled DNA breaks after 15 mins by PAGE analysis				J Med Chem 60: 3275-3288 (2017) Article DOI: 10.1021/acs.jmedchem.6b01565 BindingDB Entry DOI: 10.7270/Q24Q7X72
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1 (Homo sapiens (Human))	BDBM50237812 (CHEMBL4099532) Show SMILES CCNCCCn1c2-c3ncc(OC)cc3C(=O)c2c2ccc(cc2c1=O)[N+]([O-])=O Show InChI InChI=1S/C21H20N4O5/c1-3-22-7-4-8-24-19-17(20(26)16-10-13(30-2)11-23-18(16)19)14-6-5-12(25(28)29)9-15(14)21(24)27/h5-6,9-11,22H,3-4,7-8H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of recombinant Tdp1 (unknown origin) assessed as decrease in hydrolysis of phosphodiester linkage between tyrosine residue and the 3' end ...				J Med Chem 60: 3275-3288 (2017) Article DOI: 10.1021/acs.jmedchem.6b01565 BindingDB Entry DOI: 10.7270/Q24Q7X72
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1 (Homo sapiens (Human))	BDBM50237810 (CHEMBL4061238) Show SMILES COc1cnc-2c(c1)C(=O)c1c-2n(CCCN2CCC(N)CC2)c(=O)c2cc(ccc12)[N+]([O-])=O Show InChI InChI=1S/C24H25N5O5/c1-34-16-12-19-21(26-13-16)22-20(23(19)30)17-4-3-15(29(32)33)11-18(17)24(31)28(22)8-2-7-27-9-5-14(25)6-10-27/h3-4,11-14H,2,5-10,25H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of recombinant Tdp1 (unknown origin) assessed as decrease in hydrolysis of phosphodiester linkage between tyrosine residue and the 3' end ...				J Med Chem 60: 3275-3288 (2017) Article DOI: 10.1021/acs.jmedchem.6b01565 BindingDB Entry DOI: 10.7270/Q24Q7X72
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50237809 (CHEMBL126159) Show SMILES COc1cc2c3C(=O)c4cc5OCOc5cc4-c3n(CCCNCCO)c(=O)c2cc1OC Show InChI InChI=1S/C24H24N2O7/c1-30-17-8-13-16(11-18(17)31-2)24(29)26(6-3-4-25-5-7-27)22-14-9-19-20(33-12-32-19)10-15(14)23(28)21(13)22/h8-11,25,27H,3-7,12H2,1-2H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of recombinant human Tdp2 assessed as decrease in alpha 32P-cordycepin-3'-labeled DNA breaks after 15 mins by PAGE analysis				J Med Chem 60: 3275-3288 (2017) Article DOI: 10.1021/acs.jmedchem.6b01565 BindingDB Entry DOI: 10.7270/Q24Q7X72
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1 (Homo sapiens (Human))	BDBM50237804 (CHEMBL4097105) Show SMILES COc1cnc-2c(c1)C(=O)c1c-2n(CCCNC2=NCCS2)c(=O)c2cc(ccc12)[N+]([O-])=O |t:19| Show InChI InChI=1S/C22H19N5O5S/c1-32-13-10-16-18(25-11-13)19-17(20(16)28)14-4-3-12(27(30)31)9-15(14)21(29)26(19)7-2-5-23-22-24-6-8-33-22/h3-4,9-11H,2,5-8H2,1H3,(H,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of Cyclin-dependent kinase 2 cyclin A				J Med Chem 60: 3275-3288 (2017) Article DOI: 10.1021/acs.jmedchem.6b01565 BindingDB Entry DOI: 10.7270/Q24Q7X72
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1 (Homo sapiens (Human))	BDBM50237801 (CHEMBL4081000) Show SMILES COc1cnc-2c(c1)C(=O)c1c-2n(CCCN2CCCC2)c(=O)c2cc(ccc12)[N+]([O-])=O Show InChI InChI=1S/C23H22N4O5/c1-32-15-12-18-20(24-13-15)21-19(22(18)28)16-6-5-14(27(30)31)11-17(16)23(29)26(21)10-4-9-25-7-2-3-8-25/h5-6,11-13H,2-4,7-10H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of Cyclin-dependent kinase 2 cyclin A				J Med Chem 60: 3275-3288 (2017) Article DOI: 10.1021/acs.jmedchem.6b01565 BindingDB Entry DOI: 10.7270/Q24Q7X72
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1 (Homo sapiens (Human))	BDBM50237803 (CHEMBL4069903) Show SMILES CNCCCn1c2-c3ncc(OC)cc3C(=O)c2c2ccc(cc2c1=O)[N+]([O-])=O Show InChI InChI=1S/C20H18N4O5/c1-21-6-3-7-23-18-16(19(25)15-9-12(29-2)10-22-17(15)18)13-5-4-11(24(27)28)8-14(13)20(23)26/h4-5,8-10,21H,3,6-7H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Purdue University Curated by ChEMBL					Assay Description Inhibition of Cyclin-dependent kinase 2 cyclin A				J Med Chem 60: 3275-3288 (2017) Article DOI: 10.1021/acs.jmedchem.6b01565 BindingDB Entry DOI: 10.7270/Q24Q7X72
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50521700 (CHEMBL4449643) Show SMILES FC(F)(F)Oc1ccc(cc1)-n1c2cc(ccc2cc2c1nc(=O)[nH]c2=O)C#N Show InChI InChI=1S/C19H9F3N4O3/c20-19(21,22)29-13-5-3-12(4-6-13)26-15-7-10(9-23)1-2-11(15)8-14-16(26)24-18(28)25-17(14)27/h1-8H,(H,25,27,28)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...				J Med Chem 62: 4669-4682 (2019) Article DOI: 10.1021/acs.jmedchem.9b00274 BindingDB Entry DOI: 10.7270/Q2F1934F
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50521704 (CHEMBL4585941) Show SMILES O=c1nc2n(-c3ccc(Oc4ccccc4)cc3)c3cc(ccc3cc2c(=O)[nH]1)C#N Show InChI InChI=1S/C24H14N4O3/c25-14-15-6-7-16-13-20-22(26-24(30)27-23(20)29)28(21(16)12-15)17-8-10-19(11-9-17)31-18-4-2-1-3-5-18/h1-13H,(H,27,29,30)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...				J Med Chem 62: 4669-4682 (2019) Article DOI: 10.1021/acs.jmedchem.9b00274 BindingDB Entry DOI: 10.7270/Q2F1934F
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50521682 (CHEMBL4473717) Show SMILES Brc1ccc(COc2ccc(cc2)-n2c3cc(ccc3cc3c2nc(=O)[nH]c3=O)C#N)cc1 Show InChI InChI=1S/C25H15BrN4O3/c26-18-5-2-15(3-6-18)14-33-20-9-7-19(8-10-20)30-22-11-16(13-27)1-4-17(22)12-21-23(30)28-25(32)29-24(21)31/h1-12H,14H2,(H,29,31,32)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...				J Med Chem 62: 4669-4682 (2019) Article DOI: 10.1021/acs.jmedchem.9b00274 BindingDB Entry DOI: 10.7270/Q2F1934F
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50521705 (CHEMBL4581905) Show SMILES FC1(F)Oc2ccc(cc2O1)-n1c2cc(ccc2cc2c1nc(=O)[nH]c2=O)C#N Show InChI InChI=1S/C19H8F2N4O4/c20-19(21)28-14-4-3-11(7-15(14)29-19)25-13-5-9(8-22)1-2-10(13)6-12-16(25)23-18(27)24-17(12)26/h1-7H,(H,24,26,27)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...				J Med Chem 62: 4669-4682 (2019) Article DOI: 10.1021/acs.jmedchem.9b00274 BindingDB Entry DOI: 10.7270/Q2F1934F
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50521676 (CHEMBL4525013) Show SMILES Clc1ccc(COc2ccc(cc2)-n2c3cc(ccc3cc3c2nc(=O)[nH]c3=O)C#N)cc1 Show InChI InChI=1S/C25H15ClN4O3/c26-18-5-2-15(3-6-18)14-33-20-9-7-19(8-10-20)30-22-11-16(13-27)1-4-17(22)12-21-23(30)28-25(32)29-24(21)31/h1-12H,14H2,(H,29,31,32)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...				J Med Chem 62: 4669-4682 (2019) Article DOI: 10.1021/acs.jmedchem.9b00274 BindingDB Entry DOI: 10.7270/Q2F1934F
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50375597 (CHEMBL4169615) Show SMILES CCOC(=O)c1noc2c1C(=O)c1cccnc1C2=O Show InChI InChI=1S/C13H8N2O5/c1-2-19-13(18)9-7-10(16)6-4-3-5-14-8(6)11(17)12(7)20-15-9/h3-5H,2H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of recombinant human TDP2 using TY18 (alpha-[32P]-cordycepin-3'-labeled) as substrate after 15 mins by PAGE analysis				Eur J Med Chem 151: 777-796 (2018) Article DOI: 10.1016/j.ejmech.2018.04.024 BindingDB Entry DOI: 10.7270/Q20R9RZ8
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50375597 (CHEMBL4169615) Show SMILES CCOC(=O)c1noc2c1C(=O)c1cccnc1C2=O Show InChI InChI=1S/C13H8N2O5/c1-2-19-13(18)9-7-10(16)6-4-3-5-14-8(6)11(17)12(7)20-15-9/h3-5H,2H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human TDP2 expressed in TDP2 deficient chicken DT40 whole cell extracts using TY19 DNA as substrate after 15 mins by by PAGE analysis				Eur J Med Chem 151: 777-796 (2018) Article DOI: 10.1016/j.ejmech.2018.04.024 BindingDB Entry DOI: 10.7270/Q20R9RZ8
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50378160 (CHEMBL4161684) Show SMILES CCOC(=O)c1noc2c1C(=O)c1ncccc1C2=O Show InChI InChI=1S/C13H8N2O5/c1-2-19-13(18)9-7-11(17)8-6(4-3-5-14-8)10(16)12(7)20-15-9/h3-5H,2H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human TDP2 expressed in TDP2 deficient chicken DT40 whole cell extracts using TY19 DNA as substrate after 15 mins by by PAGE analysis				Eur J Med Chem 151: 777-796 (2018) Article DOI: 10.1016/j.ejmech.2018.04.024 BindingDB Entry DOI: 10.7270/Q20R9RZ8
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50378160 (CHEMBL4161684) Show SMILES CCOC(=O)c1noc2c1C(=O)c1ncccc1C2=O Show InChI InChI=1S/C13H8N2O5/c1-2-19-13(18)9-7-11(17)8-6(4-3-5-14-8)10(16)12(7)20-15-9/h3-5H,2H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of recombinant human TDP2 using TY18 (alpha-[32P]-cordycepin-3'-labeled) as substrate after 15 mins by PAGE analysis				Eur J Med Chem 151: 777-796 (2018) Article DOI: 10.1016/j.ejmech.2018.04.024 BindingDB Entry DOI: 10.7270/Q20R9RZ8
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50521685 (CHEMBL4469686) Show SMILES Fc1ccc(Oc2ccc(cc2)-n2c3cc(ccc3cc3c2nc(=O)[nH]c3=O)C#N)cc1 Show InChI InChI=1S/C24H13FN4O3/c25-16-3-7-18(8-4-16)32-19-9-5-17(6-10-19)29-21-11-14(13-26)1-2-15(21)12-20-22(29)27-24(31)28-23(20)30/h1-12H,(H,28,30,31)	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute Curated by ChEMBL					Assay Description Inhibition of humanized zebrafish TDP2 using 5'-(6-FAM-NHS) as substrate preincubated for 10 mins followed by substrate addition and measured after 6...				J Med Chem 62: 4669-4682 (2019) Article DOI: 10.1021/acs.jmedchem.9b00274 BindingDB Entry DOI: 10.7270/Q2F1934F
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50378166 (CHEMBL4166190) Show SMILES Cc1oc2c(c1C(=O)Oc1ccccc1O)C(=O)c1ncccc1C2=O Show InChI InChI=1S/C19H11NO6/c1-9-13(19(24)26-12-7-3-2-6-11(12)21)14-17(23)15-10(5-4-8-20-15)16(22)18(14)25-9/h2-8,21H,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human TDP2 expressed in TDP2 deficient chicken DT40 whole cell extracts using TY19 DNA as substrate after 15 mins by by PAGE analysis				Eur J Med Chem 151: 777-796 (2018) Article DOI: 10.1016/j.ejmech.2018.04.024 BindingDB Entry DOI: 10.7270/Q20R9RZ8
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1 (Homo sapiens (Human))	BDBM50450516 (CHEMBL4163805) Show SMILES COc1cc2c(OCCN3CCCC3)nc3c4cc5OCOc5cc4ccc3c2cc1OC Show InChI InChI=1S/C26H26N2O5/c1-29-21-13-19-17-6-5-16-11-23-24(33-15-32-23)12-18(16)25(17)27-26(20(19)14-22(21)30-2)31-10-9-28-7-3-4-8-28/h5-6,11-14H,3-4,7-10,15H2,1-2H3	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of recombinant human TDP1 using 5'FAM-AGGATCTAAAAGACTT-BHQ-3' as substrate preincubated for 30 mins followed by substrate addition by fluo...				J Med Chem 61: 9908-9930 (2018) Article DOI: 10.1021/acs.jmedchem.8b00639 BindingDB Entry DOI: 10.7270/Q27S7RCD
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50376549 (CHEMBL4166131) Show SMILES Cc1oc2c(c1C(=O)Oc1ccc(Cl)cc1)C(=O)c1ncccc1C2=O Show InChI InChI=1S/C19H10ClNO5/c1-9-13(19(24)26-11-6-4-10(20)5-7-11)14-17(23)15-12(3-2-8-21-15)16(22)18(14)25-9/h2-8H,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human TDP2 expressed in TDP2 deficient chicken DT40 whole cell extracts using TY19 DNA as substrate after 15 mins by by PAGE analysis				Eur J Med Chem 151: 777-796 (2018) Article DOI: 10.1016/j.ejmech.2018.04.024 BindingDB Entry DOI: 10.7270/Q20R9RZ8
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50378166 (CHEMBL4166190) Show SMILES Cc1oc2c(c1C(=O)Oc1ccccc1O)C(=O)c1ncccc1C2=O Show InChI InChI=1S/C19H11NO6/c1-9-13(19(24)26-12-7-3-2-6-11(12)21)14-17(23)15-10(5-4-8-20-15)16(22)18(14)25-9/h2-8,21H,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of recombinant human TDP2 using TY18 (alpha-[32P]-cordycepin-3'-labeled) as substrate after 15 mins by PAGE analysis				Eur J Med Chem 151: 777-796 (2018) Article DOI: 10.1016/j.ejmech.2018.04.024 BindingDB Entry DOI: 10.7270/Q20R9RZ8
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50378145 (CHEMBL4176761) Show SMILES Cc1oc2c(c1C(=O)Oc1cccnc1)C(=O)c1ncccc1C2=O Show InChI InChI=1S/C18H10N2O5/c1-9-12(18(23)25-10-4-2-6-19-8-10)13-16(22)14-11(5-3-7-20-14)15(21)17(13)24-9/h2-8H,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of human TDP2 expressed in TDP2 deficient chicken DT40 whole cell extracts using TY19 DNA as substrate after 15 mins by by PAGE analysis				Eur J Med Chem 151: 777-796 (2018) Article DOI: 10.1016/j.ejmech.2018.04.024 BindingDB Entry DOI: 10.7270/Q20R9RZ8
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Homo sapiens (Human))	BDBM50372749 (CHEMBL4164245) Show SMILES Cc1oc2c(c1C(=O)Oc1cccc(c1)-c1cn(CCCO)nn1)C(=O)c1ncccc1C2=O Show InChI InChI=1S/C24H18N4O6/c1-13-18(19-22(31)20-16(7-3-8-25-20)21(30)23(19)33-13)24(32)34-15-6-2-5-14(11-15)17-12-28(27-26-17)9-4-10-29/h2-3,5-8,11-12,29H,4,9-10H2,1H3	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-sen University Curated by ChEMBL					Assay Description Inhibition of recombinant human TDP2 using TY18 (alpha-[32P]-cordycepin-3'-labeled) as substrate after 15 mins by PAGE analysis				Eur J Med Chem 151: 777-796 (2018) Article DOI: 10.1016/j.ejmech.2018.04.024 BindingDB Entry DOI: 10.7270/Q20R9RZ8
					More data for this Ligand-Target Pair

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