Compile Data Set for Download or QSAR

Found 720 hits with Last Name = 'lugovskoy' and Initial = 'aa'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348595 (US10577374, Compound 318 | US9790229, Compound 318) Show SMILES O=C1C(CCCN1[C@@H]1CCCN(C1)c1ncnc2[nH]ccc12)Nc1ccccc1S(=O)(=O)N1CCCCC1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...				US Patent US10577374 (2020) BindingDB Entry DOI: 10.7270/Q2805502
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348596 (US10577374, Compound 319 | US9790229, Compound 319) Show SMILES Nc1ncnc(N2CCC[C@H](C2)N2CCCC(Nc3ccccc3S(=O)(=O)c3ccccc3)C2=O)c1F |r| Show InChI InChI=1S/C26H29FN6O3S/c27-23-24(28)29-17-30-25(23)32-14-6-8-18(16-32)33-15-7-12-21(26(33)34)31-20-11-4-5-13-22(20)37(35,36)19-9-2-1-3-10-19/h1-5,9-11,13,17-18,21,31H,6-8,12,14-16H2,(H2,28,29,30)/t18-,21?/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...				US Patent US10577374 (2020) BindingDB Entry DOI: 10.7270/Q2805502
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348597 (US10577374, Compound 320 | US9790229, Compound 320) Show SMILES Nc1ncnc(N2CCC[C@H](C2)N2CCCC(Nc3ccccc3S(=O)(=O)C3CCCCC3)C2=O)c1F |r| Show InChI InChI=1S/C26H35FN6O3S/c27-23-24(28)29-17-30-25(23)32-14-6-8-18(16-32)33-15-7-12-21(26(33)34)31-20-11-4-5-13-22(20)37(35,36)19-9-2-1-3-10-19/h4-5,11,13,17-19,21,31H,1-3,6-10,12,14-16H2,(H2,28,29,30)/t18-,21?/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...				US Patent US10577374 (2020) BindingDB Entry DOI: 10.7270/Q2805502
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348599 (US10577374, Compound 322 | US9790229, Compound 322) Show SMILES FC(F)(F)[C@H]1CCN(C[C@@H]1N1CC[C@@H](Nc2cc(Cl)cc(Cl)c2)C1=O)c1ncnc2[nH]ccc12 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...				US Patent US10577374 (2020) BindingDB Entry DOI: 10.7270/Q2805502
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348600 (US10577374, Compound 323 | US9790229, Compound 323) Show SMILES Clc1cc(Cl)cc(N[C@@H]2CCN([C@@H]3CCCN(C3)c3ncnc4[nH]ccc34)C2=O)c1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...				US Patent US10577374 (2020) BindingDB Entry DOI: 10.7270/Q2805502
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348601 (US10577374, Compound 324 | US9790229, Compound 324) Show SMILES Nc1ncnc(N2CC[C@H](O)[C@H](C2)N2CCCC(Nc3cc(F)cc(Cl)c3)C2=O)c1F |r| Show InChI InChI=1S/C20H23ClF2N6O2/c21-11-6-12(22)8-13(7-11)27-14-2-1-4-29(20(14)31)15-9-28(5-3-16(15)30)19-17(23)18(24)25-10-26-19/h6-8,10,14-16,27,30H,1-5,9H2,(H2,24,25,26)/t14?,15-,16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...				US Patent US10577374 (2020) BindingDB Entry DOI: 10.7270/Q2805502
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348603 (US10577374, Compound 326 | US9790229, Compound 326) Show SMILES Nc1ncnc(N2CC[C@H](O)[C@H](C2)N2CCC[C@@H](Nc3cc(Cl)cc(Cl)c3)C2=O)c1F |r| Show InChI InChI=1S/C20H23Cl2FN6O2/c21-11-6-12(22)8-13(7-11)27-14-2-1-4-29(20(14)31)15-9-28(5-3-16(15)30)19-17(23)18(24)25-10-26-19/h6-8,10,14-16,27,30H,1-5,9H2,(H2,24,25,26)/t14-,15+,16+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...				US Patent US10577374 (2020) BindingDB Entry DOI: 10.7270/Q2805502
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348604 (US10577374, Compound 327 | US9790229, Compound 327) Show SMILES Nc1ncnc(N2CC[C@@H](O)[C@@H](C2)N2CCC[C@@H](Nc3cc(Cl)cc(Cl)c3)C2=O)c1F |r| Show InChI InChI=1S/C20H23Cl2FN6O2/c21-11-6-12(22)8-13(7-11)27-14-2-1-4-29(20(14)31)15-9-28(5-3-16(15)30)19-17(23)18(24)25-10-26-19/h6-8,10,14-16,27,30H,1-5,9H2,(H2,24,25,26)/t14-,15-,16-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...				US Patent US10577374 (2020) BindingDB Entry DOI: 10.7270/Q2805502
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348606 (US10577374, Compound 329 | US9790229, Compound 329) Show SMILES Nc1ncnc(N2CC[C@@H]([C@H](C2)N2CCCC(Nc3cc(F)cc(Cl)c3)C2=O)C(F)(F)F)c1F |r| Show InChI InChI=1S/C21H22ClF5N6O/c22-11-6-12(23)8-13(7-11)31-15-2-1-4-33(20(15)34)16-9-32(5-3-14(16)21(25,26)27)19-17(24)18(28)29-10-30-19/h6-8,10,14-16,31H,1-5,9H2,(H2,28,29,30)/t14-,15?,16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...				US Patent US10577374 (2020) BindingDB Entry DOI: 10.7270/Q2805502
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348609 (US10577374, Compound 332 | US9790229, Compound 332) Show SMILES Nc1ncnc(N2CC[C@@H]([C@H](C2)N2CCC[C@@H](Nc3cc(F)cc(Cl)c3)C2=O)C(F)(F)F)c1F |r| Show InChI InChI=1S/C21H22ClF5N6O/c22-11-6-12(23)8-13(7-11)31-15-2-1-4-33(20(15)34)16-9-32(5-3-14(16)21(25,26)27)19-17(24)18(28)29-10-30-19/h6-8,10,14-16,31H,1-5,9H2,(H2,28,29,30)/t14-,15+,16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...				US Patent US10577374 (2020) BindingDB Entry DOI: 10.7270/Q2805502
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348611 (US10577374, Compound 334 | US9790229, Compound 334) Show SMILES Nc1ncnc(N2CC[C@@H]([C@H](C2)N2CCCC(Nc3cc(Cl)cc(Cl)c3)C2=O)C(F)(F)F)c1F |r| Show InChI InChI=1S/C21H22Cl2F4N6O/c22-11-6-12(23)8-13(7-11)31-15-2-1-4-33(20(15)34)16-9-32(5-3-14(16)21(25,26)27)19-17(24)18(28)29-10-30-19/h6-8,10,14-16,31H,1-5,9H2,(H2,28,29,30)/t14-,15?,16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...				US Patent US10577374 (2020) BindingDB Entry DOI: 10.7270/Q2805502
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348612 (US10577374, Compound 335 | US9790229, Compound 335) Show SMILES Nc1ncnc(N2CC[C@H]([C@@H](C2)N2CCC[C@@H](Nc3cc(Cl)cc(Cl)c3)C2=O)C(F)(F)F)c1F |r| Show InChI InChI=1S/C21H22Cl2F4N6O/c22-11-6-12(23)8-13(7-11)31-15-2-1-4-33(20(15)34)16-9-32(5-3-14(16)21(25,26)27)19-17(24)18(28)29-10-30-19/h6-8,10,14-16,31H,1-5,9H2,(H2,28,29,30)/t14-,15-,16-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...				US Patent US10577374 (2020) BindingDB Entry DOI: 10.7270/Q2805502
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348614 (US10577374, Compound 337 | US9790229, Compound 337) Show SMILES Nc1ncnc(N2CC[C@@H]([C@H](C2)N2CCC[C@@H](Nc3cc(Cl)cc(Cl)c3)C2=O)C(F)(F)F)c1F |r| Show InChI InChI=1S/C21H22Cl2F4N6O/c22-11-6-12(23)8-13(7-11)31-15-2-1-4-33(20(15)34)16-9-32(5-3-14(16)21(25,26)27)19-17(24)18(28)29-10-30-19/h6-8,10,14-16,31H,1-5,9H2,(H2,28,29,30)/t14-,15+,16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...				US Patent US10577374 (2020) BindingDB Entry DOI: 10.7270/Q2805502
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348616 (US10577374, Compound 339 | US9790229, Compound 339) Show SMILES FC(F)(F)[C@H]1CCN(C[C@@H]1N1CCCC(Nc2cc(Cl)cc(Cl)c2)C1=O)c1ncnc2[nH]ccc12 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...				US Patent US10577374 (2020) BindingDB Entry DOI: 10.7270/Q2805502
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348618 (US10577374, Compound 341 | US9790229, Compound 341) Show SMILES Nc1ncnc(N2CC[C@@H](F)[C@H](C2)N2CCC[C@@H](Nc3cc(F)cc(Cl)c3)C2=O)c1F |r| Show InChI InChI=1S/C20H22ClF3N6O/c21-11-6-12(22)8-13(7-11)28-15-2-1-4-30(20(15)31)16-9-29(5-3-14(16)23)19-17(24)18(25)26-10-27-19/h6-8,10,14-16,28H,1-5,9H2,(H2,25,26,27)/t14-,15-,16+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...				US Patent US10577374 (2020) BindingDB Entry DOI: 10.7270/Q2805502
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348621 (US10577374, Compound 344 | US9790229, Compound 344) Show SMILES Nc1ncnc(N2CCOCC(C2)N2CCCC(Nc3cc(Cl)cc(Cl)c3)C2=O)c1F Show InChI InChI=1S/C20H23Cl2FN6O2/c21-12-6-13(22)8-14(7-12)27-16-2-1-3-29(20(16)30)15-9-28(4-5-31-10-15)19-17(23)18(24)25-11-26-19/h6-8,11,15-16,27H,1-5,9-10H2,(H2,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...				US Patent US10577374 (2020) BindingDB Entry DOI: 10.7270/Q2805502
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348622 (US10577374, Compound 345 | US9790229, Compound 345) Show SMILES Nc1ncnc(N2CCOCC(C2)N2CCCC(Nc3cc(F)cc(Cl)c3)C2=O)c1F Show InChI InChI=1S/C20H23ClF2N6O2/c21-12-6-13(22)8-14(7-12)27-16-2-1-3-29(20(16)30)15-9-28(4-5-31-10-15)19-17(23)18(24)25-11-26-19/h6-8,11,15-16,27H,1-5,9-10H2,(H2,24,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...				US Patent US10577374 (2020) BindingDB Entry DOI: 10.7270/Q2805502
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348623 (US10577374, Compound 346 | US9790229, Compound 346) Show SMILES Nc1ncnc(N2CCC[C@H](C2)N2CCCC[C@@H](Nc3cc(F)cc(Cl)c3)C2=O)c1F |r| Show InChI InChI=1S/C21H25ClF2N6O/c22-13-8-14(23)10-15(9-13)28-17-5-1-2-7-30(21(17)31)16-4-3-6-29(11-16)20-18(24)19(25)26-12-27-20/h8-10,12,16-17,28H,1-7,11H2,(H2,25,26,27)/t16-,17-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...				US Patent US10577374 (2020) BindingDB Entry DOI: 10.7270/Q2805502
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348624 (US10577374, Compound 347 | US9790229, Compound 347) Show SMILES Nc1ncnc(N2CCC[C@H](C2)N2CC=CC[C@@H](Nc3cc(F)cc(Cl)c3)C2=O)c1F |r,c:15| Show InChI InChI=1S/C21H23ClF2N6O/c22-13-8-14(23)10-15(9-13)28-17-5-1-2-7-30(21(17)31)16-4-3-6-29(11-16)20-18(24)19(25)26-12-27-20/h1-2,8-10,12,16-17,28H,3-7,11H2,(H2,25,26,27)/t16-,17-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...				US Patent US10577374 (2020) BindingDB Entry DOI: 10.7270/Q2805502
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348625 (US10577374, Compound 348 | US9790229, Compound 348) Show SMILES Nc1ncnc(N2CCC[C@H](C2)N2CC(O)C(O)C[C@@H](Nc3cc(F)cc(Cl)c3)C2=O)c1F |r| Show InChI InChI=1S/C21H25ClF2N6O3/c22-11-4-12(23)6-13(5-11)28-15-7-16(31)17(32)9-30(21(15)33)14-2-1-3-29(8-14)20-18(24)19(25)26-10-27-20/h4-6,10,14-17,28,31-32H,1-3,7-9H2,(H2,25,26,27)/t14-,15-,16?,17?/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...				US Patent US10577374 (2020) BindingDB Entry DOI: 10.7270/Q2805502
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348626 (US10577374, Compound 349 | US9790229, Compound 349) Show SMILES Nc1ncnc(N2CCC(C(C2)N2CC=CC[C@@H](Nc3cc(F)cc(Cl)c3)C2=O)C(F)(F)F)c1F |r,c:15| Show InChI InChI=1S/C22H22ClF5N6O/c23-12-7-13(24)9-14(8-12)32-16-3-1-2-5-34(21(16)35)17-10-33(6-4-15(17)22(26,27)28)20-18(25)19(29)30-11-31-20/h1-2,7-9,11,15-17,32H,3-6,10H2,(H2,29,30,31)/t15?,16-,17?/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...				US Patent US10577374 (2020) BindingDB Entry DOI: 10.7270/Q2805502
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348627 (US10577374, Compound 350 | US9790229, Compound 350) Show SMILES Nc1ncnc(N2CC[C@H]([C@@H](C2)N2CC=CC[C@@H](Nc3cc(F)cc(Cl)c3)C2=O)C(F)(F)F)c1F |r,c:15| Show InChI InChI=1S/C22H22ClF5N6O/c23-12-7-13(24)9-14(8-12)32-16-3-1-2-5-34(21(16)35)17-10-33(6-4-15(17)22(26,27)28)20-18(25)19(29)30-11-31-20/h1-2,7-9,11,15-17,32H,3-6,10H2,(H2,29,30,31)/t15-,16-,17-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...				US Patent US10577374 (2020) BindingDB Entry DOI: 10.7270/Q2805502
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348629 (US10577374, Compound 352 | US9790229, Compound 352) Show SMILES Fc1cc(Cl)cc(NC2CCCN([C@H]3CN(CC[C@@H]3C(F)(F)F)c3ncnc4[nH]ccc34)C2=O)c1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...				US Patent US10577374 (2020) BindingDB Entry DOI: 10.7270/Q2805502
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348630 (US10577374, Compound 353 | US9790229, Compound 353) Show SMILES Nc1ncnc(N2CC[C@@H]([C@H](C2)N2CC[C@@H](Nc3cc(Cl)cc(Cl)c3)C2=O)C(F)(F)F)c1F |r| Show InChI InChI=1S/C20H20Cl2F4N6O/c21-10-5-11(22)7-12(6-10)30-14-2-4-32(19(14)33)15-8-31(3-1-13(15)20(24,25)26)18-16(23)17(27)28-9-29-18/h5-7,9,13-15,30H,1-4,8H2,(H2,27,28,29)/t13-,14+,15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...				US Patent US10577374 (2020) BindingDB Entry DOI: 10.7270/Q2805502
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348632 (US10577374, Compound 355 | US9790229, Compound 355) Show SMILES FC(F)(F)[C@H]1CCN(C[C@@H]1N1CC[C@@H](Nc2cc(Cl)cc(Cl)c2)C1=O)c1ncnc2[nH]ncc12 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...				US Patent US10577374 (2020) BindingDB Entry DOI: 10.7270/Q2805502
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348634 (US10577374, Compound 357 | US9790229, Compound 357) Show SMILES Clc1cc(Cl)cc(N[C@H]2CCN([C@@H]3CCCN(C3)c3ncnc4[nH]ccc34)C2=O)c1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...				US Patent US10577374 (2020) BindingDB Entry DOI: 10.7270/Q2805502
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348636 (US10577374, Compound 359 | US9790229, Compound 359) Show SMILES Nc1ncnc(N2CC(CC(F)(F)C2)N2CCCC(Nc3cc(F)cc(Cl)c3)C2=O)c1F Show InChI InChI=1S/C20H21ClF4N6O/c21-11-4-12(22)6-13(5-11)29-15-2-1-3-31(19(15)32)14-7-20(24,25)9-30(8-14)18-16(23)17(26)27-10-28-18/h4-6,10,14-15,29H,1-3,7-9H2,(H2,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...				US Patent US10577374 (2020) BindingDB Entry DOI: 10.7270/Q2805502
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348637 (US10577374, Compound 360 | US9790229, Compound 360) Show SMILES Fc1cc(Cl)cc(NC2CCCN([C@@H]3CCCN(C3)c3ncnc4[nH]ncc34)C2=O)c1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...				US Patent US10577374 (2020) BindingDB Entry DOI: 10.7270/Q2805502
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348638 (US10577374, Compound 361 | US9790229, Compound 361) Show SMILES Nc1cc(ncn1)N1CCC[C@H](C1)N1CCCC(Nc2cc(F)cc(Cl)c2)C1=O |r| Show InChI InChI=1S/C20H24ClFN6O/c21-13-7-14(22)9-15(8-13)26-17-4-2-6-28(20(17)29)16-3-1-5-27(11-16)19-10-18(23)24-12-25-19/h7-10,12,16-17,26H,1-6,11H2,(H2,23,24,25)/t16-,17?/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...				US Patent US10577374 (2020) BindingDB Entry DOI: 10.7270/Q2805502
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348326 (US9790229, Compound 49) Show SMILES O=CNc1cccc(c1)C1CCCN(C1)c1ncnc2[nH]ccc12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...				US Patent US9790229 (2017) BindingDB Entry DOI: 10.7270/Q22809RK
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348625 (US10577374, Compound 348 | US9790229, Compound 348) Show SMILES Nc1ncnc(N2CCC[C@H](C2)N2CC(O)C(O)C[C@@H](Nc3cc(F)cc(Cl)c3)C2=O)c1F |r| Show InChI InChI=1S/C21H25ClF2N6O3/c22-11-4-12(23)6-13(5-11)28-15-7-16(31)17(32)9-30(21(15)33)14-2-1-3-29(8-14)20-18(24)19(25)26-10-27-20/h4-6,10,14-17,28,31-32H,1-3,7-9H2,(H2,25,26,27)/t14-,15-,16?,17?/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...				US Patent US9790229 (2017) BindingDB Entry DOI: 10.7270/Q22809RK
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348626 (US10577374, Compound 349 | US9790229, Compound 349) Show SMILES Nc1ncnc(N2CCC(C(C2)N2CC=CC[C@@H](Nc3cc(F)cc(Cl)c3)C2=O)C(F)(F)F)c1F |r,c:15| Show InChI InChI=1S/C22H22ClF5N6O/c23-12-7-13(24)9-14(8-12)32-16-3-1-2-5-34(21(16)35)17-10-33(6-4-15(17)22(26,27)28)20-18(25)19(29)30-11-31-20/h1-2,7-9,11,15-17,32H,3-6,10H2,(H2,29,30,31)/t15?,16-,17?/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...				US Patent US9790229 (2017) BindingDB Entry DOI: 10.7270/Q22809RK
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348627 (US10577374, Compound 350 | US9790229, Compound 350) Show SMILES Nc1ncnc(N2CC[C@H]([C@@H](C2)N2CC=CC[C@@H](Nc3cc(F)cc(Cl)c3)C2=O)C(F)(F)F)c1F |r,c:15| Show InChI InChI=1S/C22H22ClF5N6O/c23-12-7-13(24)9-14(8-12)32-16-3-1-2-5-34(21(16)35)17-10-33(6-4-15(17)22(26,27)28)20-18(25)19(29)30-11-31-20/h1-2,7-9,11,15-17,32H,3-6,10H2,(H2,29,30,31)/t15-,16-,17-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...				US Patent US9790229 (2017) BindingDB Entry DOI: 10.7270/Q22809RK
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348629 (US10577374, Compound 352 | US9790229, Compound 352) Show SMILES Fc1cc(Cl)cc(NC2CCCN([C@H]3CN(CC[C@@H]3C(F)(F)F)c3ncnc4[nH]ccc34)C2=O)c1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...				US Patent US9790229 (2017) BindingDB Entry DOI: 10.7270/Q22809RK
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348630 (US10577374, Compound 353 | US9790229, Compound 353) Show SMILES Nc1ncnc(N2CC[C@@H]([C@H](C2)N2CC[C@@H](Nc3cc(Cl)cc(Cl)c3)C2=O)C(F)(F)F)c1F |r| Show InChI InChI=1S/C20H20Cl2F4N6O/c21-10-5-11(22)7-12(6-10)30-14-2-4-32(19(14)33)15-8-31(3-1-13(15)20(24,25)26)18-16(23)17(27)28-9-29-18/h5-7,9,13-15,30H,1-4,8H2,(H2,27,28,29)/t13-,14+,15-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...				US Patent US9790229 (2017) BindingDB Entry DOI: 10.7270/Q22809RK
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348632 (US10577374, Compound 355 | US9790229, Compound 355) Show SMILES FC(F)(F)[C@H]1CCN(C[C@@H]1N1CC[C@@H](Nc2cc(Cl)cc(Cl)c2)C1=O)c1ncnc2[nH]ncc12 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...				US Patent US9790229 (2017) BindingDB Entry DOI: 10.7270/Q22809RK
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348634 (US10577374, Compound 357 | US9790229, Compound 357) Show SMILES Clc1cc(Cl)cc(N[C@H]2CCN([C@@H]3CCCN(C3)c3ncnc4[nH]ccc34)C2=O)c1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...				US Patent US9790229 (2017) BindingDB Entry DOI: 10.7270/Q22809RK
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348636 (US10577374, Compound 359 | US9790229, Compound 359) Show SMILES Nc1ncnc(N2CC(CC(F)(F)C2)N2CCCC(Nc3cc(F)cc(Cl)c3)C2=O)c1F Show InChI InChI=1S/C20H21ClF4N6O/c21-11-4-12(22)6-13(5-11)29-15-2-1-3-31(19(15)32)14-7-20(24,25)9-30(8-14)18-16(23)17(26)27-10-28-18/h4-6,10,14-15,29H,1-3,7-9H2,(H2,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...				US Patent US9790229 (2017) BindingDB Entry DOI: 10.7270/Q22809RK
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348637 (US10577374, Compound 360 | US9790229, Compound 360) Show SMILES Fc1cc(Cl)cc(NC2CCCN([C@@H]3CCCN(C3)c3ncnc4[nH]ncc34)C2=O)c1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...				US Patent US9790229 (2017) BindingDB Entry DOI: 10.7270/Q22809RK
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348638 (US10577374, Compound 361 | US9790229, Compound 361) Show SMILES Nc1cc(ncn1)N1CCC[C@H](C1)N1CCCC(Nc2cc(F)cc(Cl)c2)C1=O |r| Show InChI InChI=1S/C20H24ClFN6O/c21-13-7-14(22)9-15(8-13)26-17-4-2-6-28(20(17)29)16-3-1-5-27(11-16)19-10-18(23)24-12-25-19/h7-10,12,16-17,26H,1-6,11H2,(H2,23,24,25)/t16-,17?/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...				US Patent US9790229 (2017) BindingDB Entry DOI: 10.7270/Q22809RK
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348314 (US10577374, Compound 37 | US9790229, Compound 37) Show SMILES O=C(Nc1cccc(c1)C1CCCN(C1)c1ncnc2[nH]ccc12)Nc1ccccc1N1CCCC1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...				US Patent US9790229 (2017) BindingDB Entry DOI: 10.7270/Q22809RK
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348323 (US10577374, Compound 46 | US9790229, Compound 46) Show SMILES O=C(Nc1cccc(c1)[C@H]1CCCN(C1)c1ncnc2[nH]ccc12)Nc1ccccc1N1CCCC1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...				US Patent US9790229 (2017) BindingDB Entry DOI: 10.7270/Q22809RK
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348327 (US10577374, Compound 50 | US9790229, Compound 50) Show SMILES Clc1cccc(N2CCCC2)c1NC(=O)Nc1cccc(c1)C1CCCN(C1)c1ncnc2[nH]ccc12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...				US Patent US9790229 (2017) BindingDB Entry DOI: 10.7270/Q22809RK
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348329 (US10577374, Compound 52 | US9790229, Compound 52) Show SMILES C[C@@H]1CCCN1c1cccc(F)c1NC(=O)Nc1cccc(c1)C1CCCN(C1)c1ncnc2[nH]ccc12 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound inhibition is measured a...				US Patent US9790229 (2017) BindingDB Entry DOI: 10.7270/Q22809RK
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348314 (US10577374, Compound 37 | US9790229, Compound 37) Show SMILES O=C(Nc1cccc(c1)C1CCCN(C1)c1ncnc2[nH]ccc12)Nc1ccccc1N1CCCC1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...				US Patent US10577374 (2020) BindingDB Entry DOI: 10.7270/Q2805502
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348323 (US10577374, Compound 46 | US9790229, Compound 46) Show SMILES O=C(Nc1cccc(c1)[C@H]1CCCN(C1)c1ncnc2[nH]ccc12)Nc1ccccc1N1CCCC1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...				US Patent US10577374 (2020) BindingDB Entry DOI: 10.7270/Q2805502
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM434888 (US10577374, Compound 49) Show SMILES Nc1c(F)cc(F)cc1N1CCCC1.O=CNc1cccc(c1)C1CCCN(C1)c1ncnc2[nH]ccc12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...				US Patent US10577374 (2020) BindingDB Entry DOI: 10.7270/Q2805502
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348327 (US10577374, Compound 50 | US9790229, Compound 50) Show SMILES Clc1cccc(N2CCCC2)c1NC(=O)Nc1cccc(c1)C1CCCN(C1)c1ncnc2[nH]ccc12 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...				US Patent US10577374 (2020) BindingDB Entry DOI: 10.7270/Q2805502
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348329 (US10577374, Compound 52 | US9790229, Compound 52) Show SMILES C[C@@H]1CCCN1c1cccc(F)c1NC(=O)Nc1cccc(c1)C1CCCN(C1)c1ncnc2[nH]ccc12 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...				US Patent US10577374 (2020) BindingDB Entry DOI: 10.7270/Q2805502
					More data for this Ligand-Target Pair
Tyrosine-protein kinase BTK (Homo sapiens (Human))	BDBM348384 (US10577374, Compound 107 | US9790229, Compound 107) Show SMILES O=C(Nc1csc(n1)C1CCCN(C1)c1ncnc2[nH]ccc12)Nc1ccccc1N1CCCC1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Sunesis Pharmaceuticals, Inc.; Biogen MA Inc. US Patent					Assay Description BTK-POLYGAT-LS ASSAY. The purpose of the BTK in vitro assay is to determine compound potency against BTK through the measurement of IC50. Compound in...				US Patent US10577374 (2020) BindingDB Entry DOI: 10.7270/Q2805502
					More data for this Ligand-Target Pair

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