Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM14805 (3-(5,6-Diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylami...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP.... | J Med Chem 48: 4332-45 (2005) Article DOI: 10.1021/jm049022c BindingDB Entry DOI: 10.7270/Q2WW7FXS | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human)) | BDBM14805 (3-(5,6-Diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylami...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Human CDK1 kinase activity was assayed in reaction buffer containing substrate Histone H1, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-... | J Med Chem 48: 4332-45 (2005) Article DOI: 10.1021/jm049022c BindingDB Entry DOI: 10.7270/Q2WW7FXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM14803 (2-(5,6-Diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylami...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP.... | J Med Chem 48: 4332-45 (2005) Article DOI: 10.1021/jm049022c BindingDB Entry DOI: 10.7270/Q2WW7FXS | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human)) | BDBM14804 (1-(5,6-Diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylami...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 3.70E+3 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Human CDK1 kinase activity was assayed in reaction buffer containing substrate Histone H1, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-... | J Med Chem 48: 4332-45 (2005) Article DOI: 10.1021/jm049022c BindingDB Entry DOI: 10.7270/Q2WW7FXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human)) | BDBM14803 (2-(5,6-Diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylami...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Human CDK1 kinase activity was assayed in reaction buffer containing substrate Histone H1, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-... | J Med Chem 48: 4332-45 (2005) Article DOI: 10.1021/jm049022c BindingDB Entry DOI: 10.7270/Q2WW7FXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM14804 (1-(5,6-Diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylami...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP.... | J Med Chem 48: 4332-45 (2005) Article DOI: 10.1021/jm049022c BindingDB Entry DOI: 10.7270/Q2WW7FXS | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM14801 (2-({5,6-diphenylfuro[2,3-d]pyrimidin-4-yl}(methyl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 6.10E+3 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP.... | J Med Chem 48: 4332-45 (2005) Article DOI: 10.1021/jm049022c BindingDB Entry DOI: 10.7270/Q2WW7FXS | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM14818 (2-{[7-(carboxymethoxy)-9-(hydroxyimino)-9H-fluoren...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 1.34E+4 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP.... | Bioorg Med Chem 14: 4792-802 (2006) Article DOI: 10.1016/j.bmc.2006.03.021 BindingDB Entry DOI: 10.7270/Q2S46Q6S | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM14799 (2-[5,6-Bis-(4-methoxy-phenyl)-furo[2,3-d]pyrimidin...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 1.54E+4 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP.... | J Med Chem 48: 4332-45 (2005) Article DOI: 10.1021/jm049022c BindingDB Entry DOI: 10.7270/Q2WW7FXS | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM14823 (2-[(6-amino-9H-purin-8-yl)sulfanyl]acetamide | Asi...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 1.56E+4 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP.... | Bioorg Med Chem 14: 4792-802 (2006) Article DOI: 10.1016/j.bmc.2006.03.021 BindingDB Entry DOI: 10.7270/Q2S46Q6S | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM14815 (InterBioScreen compound 2 | N-(3-aminopropyl)-5-ch...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.58E+4 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP.... | Bioorg Med Chem 14: 4792-802 (2006) Article DOI: 10.1016/j.bmc.2006.03.021 BindingDB Entry DOI: 10.7270/Q2S46Q6S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM14822 (4-[3-(4-amino-1,2,5-oxadiazol-3-yl)-1-propyl-1H-1,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MMDB PC cid PC sid PDB UniChem | MMDB PDB Article PubMed | n/a | n/a | 1.73E+4 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP.... | Bioorg Med Chem 14: 4792-802 (2006) Article DOI: 10.1016/j.bmc.2006.03.021 BindingDB Entry DOI: 10.7270/Q2S46Q6S | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM14819 ((1E)-1-[(6-chloro-2H-1,3-benzodioxol-5-yl)methylid...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.01E+4 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP.... | Bioorg Med Chem 14: 4792-802 (2006) Article DOI: 10.1016/j.bmc.2006.03.021 BindingDB Entry DOI: 10.7270/Q2S46Q6S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM14816 (6-amino-4-(3,4-dihydroxyphenyl)-3-methyl-1H,4H-pyr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.04E+4 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP.... | Bioorg Med Chem 14: 4792-802 (2006) Article DOI: 10.1016/j.bmc.2006.03.021 BindingDB Entry DOI: 10.7270/Q2S46Q6S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM14800 (2-(5,6-Diphenyl-furo[2,3-d]pyrimidin-4-ylamino)-et...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 2.09E+4 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP.... | J Med Chem 48: 4332-45 (2005) Article DOI: 10.1021/jm049022c BindingDB Entry DOI: 10.7270/Q2WW7FXS | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM14802 ((5,6-Diphenyl-furo[2,3-d]pyrimidin-4-ylamino)-acet...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | MMDB PDB Article PubMed | n/a | n/a | 2.29E+4 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP.... | J Med Chem 48: 4332-45 (2005) Article DOI: 10.1021/jm049022c BindingDB Entry DOI: 10.7270/Q2WW7FXS | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM14817 (4-{[5-(5-chloro-2-methoxyphenyl)-1,3,4-thiadiazol-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.66E+4 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP.... | Bioorg Med Chem 14: 4792-802 (2006) Article DOI: 10.1016/j.bmc.2006.03.021 BindingDB Entry DOI: 10.7270/Q2S46Q6S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM14821 ((2S)-1-amino-3-[(5-nitroquinolin-8-yl)amino]propan...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase DrugBank MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB Article PubMed | n/a | n/a | 2.73E+4 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP.... | Bioorg Med Chem 14: 4792-802 (2006) Article DOI: 10.1016/j.bmc.2006.03.021 BindingDB Entry DOI: 10.7270/Q2S46Q6S | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human)) | BDBM14799 (2-[5,6-Bis-(4-methoxy-phenyl)-furo[2,3-d]pyrimidin...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.94E+4 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Human CDK1 kinase activity was assayed in reaction buffer containing substrate Histone H1, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-... | J Med Chem 48: 4332-45 (2005) Article DOI: 10.1021/jm049022c BindingDB Entry DOI: 10.7270/Q2WW7FXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM14814 (2-[(6-amino-9H-purin-8-yl)sulfanyl]acetic acid | A...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.18E+4 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP.... | Bioorg Med Chem 14: 4792-802 (2006) Article DOI: 10.1016/j.bmc.2006.03.021 BindingDB Entry DOI: 10.7270/Q2S46Q6S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM14820 (3-amino-5-[(3Z)-5-nitro-2-oxo-2,3-dihydro-1H-indol...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.27E+4 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP.... | Bioorg Med Chem 14: 4792-802 (2006) Article DOI: 10.1016/j.bmc.2006.03.021 BindingDB Entry DOI: 10.7270/Q2S46Q6S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM14810 (2-(5,6-Diphenyl-furo[2,3-d]pyrimidin-4-ylamino)-2-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP.... | J Med Chem 48: 4332-45 (2005) Article DOI: 10.1021/jm049022c BindingDB Entry DOI: 10.7270/Q2WW7FXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM14811 (N-(2-aminoethyl)-5,6-diphenylfuro[2,3-d]pyrimidin-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP.... | J Med Chem 48: 4332-45 (2005) Article DOI: 10.1021/jm049022c BindingDB Entry DOI: 10.7270/Q2WW7FXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM14812 ((5,6-Diphenyl-furo[2,3-d]pyrimidin-4-yl)-(2-methox...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP.... | J Med Chem 48: 4332-45 (2005) Article DOI: 10.1021/jm049022c BindingDB Entry DOI: 10.7270/Q2WW7FXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM14813 (2-({5,6-diphenylfuro[2,3-d]pyrimidin-4-yl}amino)pr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP.... | J Med Chem 48: 4332-45 (2005) Article DOI: 10.1021/jm049022c BindingDB Entry DOI: 10.7270/Q2WW7FXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM14808 (Benzyl-(5,6-diphenyl-furo[2,3-d]pyrimidin-4-yl)-am...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP.... | J Med Chem 48: 4332-45 (2005) Article DOI: 10.1021/jm049022c BindingDB Entry DOI: 10.7270/Q2WW7FXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM14806 (5,6-Diphenyl-furo[2,3-d]pyrimidin-4 -ylamine | 5,6...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP.... | J Med Chem 48: 4332-45 (2005) Article DOI: 10.1021/jm049022c BindingDB Entry DOI: 10.7270/Q2WW7FXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM14807 (3-(5,6-Diphenyl-furo[2,3-d]pyrimidin-4-ylamino)-pr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP.... | J Med Chem 48: 4332-45 (2005) Article DOI: 10.1021/jm049022c BindingDB Entry DOI: 10.7270/Q2WW7FXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM14809 (N-(5,6-Diphenyl-furo[2,3-d]pyrimidin-4-yl)-benzami...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Chk1 kinase activity was assayed in reaction buffer containing substrate peptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P] ATP.... | J Med Chem 48: 4332-45 (2005) Article DOI: 10.1021/jm049022c BindingDB Entry DOI: 10.7270/Q2WW7FXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human)) | BDBM14801 (2-({5,6-diphenylfuro[2,3-d]pyrimidin-4-yl}(methyl)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.11E+5 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Human CDK1 kinase activity was assayed in reaction buffer containing substrate Histone H1, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-... | J Med Chem 48: 4332-45 (2005) Article DOI: 10.1021/jm049022c BindingDB Entry DOI: 10.7270/Q2WW7FXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human)) | BDBM14802 ((5,6-Diphenyl-furo[2,3-d]pyrimidin-4-ylamino)-acet...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Human CDK1 kinase activity was assayed in reaction buffer containing substrate Histone H1, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-... | J Med Chem 48: 4332-45 (2005) Article DOI: 10.1021/jm049022c BindingDB Entry DOI: 10.7270/Q2WW7FXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Homo sapiens (Human)) | BDBM14800 (2-(5,6-Diphenyl-furo[2,3-d]pyrimidin-4-ylamino)-et...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet | Purchase DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Human CDK1 kinase activity was assayed in reaction buffer containing substrate Histone H1, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-... | J Med Chem 48: 4332-45 (2005) Article DOI: 10.1021/jm049022c BindingDB Entry DOI: 10.7270/Q2WW7FXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-dependent protein kinase catalytic subunit alpha (Homo sapiens (Human)) | BDBM14799 (2-[5,6-Bis-(4-methoxy-phenyl)-furo[2,3-d]pyrimidin...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Human PKA kinase activity was assayed in reaction buffer containing substrate Kemptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P... | J Med Chem 48: 4332-45 (2005) Article DOI: 10.1021/jm049022c BindingDB Entry DOI: 10.7270/Q2WW7FXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-dependent protein kinase catalytic subunit alpha (Homo sapiens (Human)) | BDBM14800 (2-(5,6-Diphenyl-furo[2,3-d]pyrimidin-4-ylamino)-et...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Human PKA kinase activity was assayed in reaction buffer containing substrate Kemptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P... | J Med Chem 48: 4332-45 (2005) Article DOI: 10.1021/jm049022c BindingDB Entry DOI: 10.7270/Q2WW7FXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-dependent protein kinase catalytic subunit alpha (Homo sapiens (Human)) | BDBM14805 (3-(5,6-Diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylami...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Human PKA kinase activity was assayed in reaction buffer containing substrate Kemptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P... | J Med Chem 48: 4332-45 (2005) Article DOI: 10.1021/jm049022c BindingDB Entry DOI: 10.7270/Q2WW7FXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-dependent protein kinase catalytic subunit alpha (Homo sapiens (Human)) | BDBM14802 ((5,6-Diphenyl-furo[2,3-d]pyrimidin-4-ylamino)-acet...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Human PKA kinase activity was assayed in reaction buffer containing substrate Kemptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P... | J Med Chem 48: 4332-45 (2005) Article DOI: 10.1021/jm049022c BindingDB Entry DOI: 10.7270/Q2WW7FXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-dependent protein kinase catalytic subunit alpha (Homo sapiens (Human)) | BDBM14803 (2-(5,6-Diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylami...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Human PKA kinase activity was assayed in reaction buffer containing substrate Kemptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P... | J Med Chem 48: 4332-45 (2005) Article DOI: 10.1021/jm049022c BindingDB Entry DOI: 10.7270/Q2WW7FXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-dependent protein kinase catalytic subunit alpha (Homo sapiens (Human)) | BDBM14804 (1-(5,6-Diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylami...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Human PKA kinase activity was assayed in reaction buffer containing substrate Kemptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P... | J Med Chem 48: 4332-45 (2005) Article DOI: 10.1021/jm049022c BindingDB Entry DOI: 10.7270/Q2WW7FXS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-dependent protein kinase catalytic subunit alpha (Homo sapiens (Human)) | BDBM14801 (2-({5,6-diphenylfuro[2,3-d]pyrimidin-4-yl}(methyl)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | DrugBank MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Vernalis (R&D) Ltd | Assay Description Human PKA kinase activity was assayed in reaction buffer containing substrate Kemptide, enzyme, and inhibitor in the presence of 100uM ATP/[gamma-33P... | J Med Chem 48: 4332-45 (2005) Article DOI: 10.1021/jm049022c BindingDB Entry DOI: 10.7270/Q2WW7FXS | |||||||||||
More data for this Ligand-Target Pair |