Compile Data Set for Download or QSAR

Found 38 hits with Last Name = 'bowler' and Initial = 'an'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Adenosine receptor A3 (Homo sapiens (Human))	BDBM21221 ((2S,3S,4R,5R)-5-(2-chloro-6-{[(3-iodophenyl)methyl...) Show SMILES CNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NCc3cccc(I)c3)nc(Cl)nc12 Show InChI InChI=1S/C18H18ClIN6O4/c1-21-16(29)13-11(27)12(28)17(30-13)26-7-23-10-14(24-18(19)25-15(10)26)22-6-8-3-2-4-9(20)5-8/h2-5,7,11-13,17,27-28H,6H2,1H3,(H,21,29)(H,22,24,25)/t11-,12+,13-,17+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Binding affinity for adenosine A3 receptor as inhibition of [125I]-AB-MECA binding to human receptor expressed in HEK 293 cells				Bioorg Med Chem Lett 8: 1767-70 (1999) BindingDB Entry DOI: 10.7270/Q2PR7V3R
					More data for this Ligand-Target Pair
Adenosine receptor A3 (Homo sapiens (Human))	BDBM50070866 ((2R,3R,4S,5R)-2-[2-Chloro-6-(3-iodo-benzylamino)-p...) Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1c1ccon1)n1cnc2c(NCc3cccc(I)c3)nc(Cl)nc12 Show InChI InChI=1S/C19H16ClIN6O4/c20-19-24-16(22-7-9-2-1-3-10(21)6-9)12-17(25-19)27(8-23-12)18-14(29)13(28)15(31-18)11-4-5-30-26-11/h1-6,8,13-15,18,28-29H,7H2,(H,22,24,25)/t13-,14+,15+,18+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	7.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Binding affinity for adenosine A3 receptor as inhibition of [125I]-AB-MECA binding to human receptor expressed in HEK 293 cells				Bioorg Med Chem Lett 8: 1767-70 (1999) BindingDB Entry DOI: 10.7270/Q2PR7V3R
					More data for this Ligand-Target Pair
Adenosine receptor A3 (Homo sapiens (Human))	BDBM50070867 ((2R,3R,4S,5R)-2-(2-Chloro-6-methoxyamino-purin-9-y...) Show SMILES CONc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](C=C)[C@@H](O)[C@H]1O Show InChI InChI=1S/C12H14ClN5O4/c1-3-5-7(19)8(20)11(22-5)18-4-14-6-9(17-21-2)15-12(13)16-10(6)18/h3-5,7-8,11,19-20H,1H2,2H3,(H,15,16,17)/t5-,7-,8-,11-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Binding affinity for adenosine A3 receptor as inhibition of [125I]-AB-MECA binding to human receptor expressed in HEK 293 cells				Bioorg Med Chem Lett 8: 1767-70 (1999) BindingDB Entry DOI: 10.7270/Q2PR7V3R
					More data for this Ligand-Target Pair
Adenosine receptor A3 (Homo sapiens (Human))	BDBM50070864 ((2R,3R,4S,5S)-2-(2-Chloro-6-methoxyamino-purin-9-y...) Show SMILES CONc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](CCl)[C@@H](O)[C@H]1O Show InChI InChI=1S/C11H13Cl2N5O4/c1-21-17-8-5-9(16-11(13)15-8)18(3-14-5)10-7(20)6(19)4(2-12)22-10/h3-4,6-7,10,19-20H,2H2,1H3,(H,15,16,17)/t4-,6-,7-,10-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	26	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Binding affinity for adenosine A3 receptor as inhibition of [125I]-AB-MECA binding to human receptor expressed in HEK 293 cells				Bioorg Med Chem Lett 8: 1767-70 (1999) BindingDB Entry DOI: 10.7270/Q2PR7V3R
					More data for this Ligand-Target Pair
Adenosine receptor A3 (Homo sapiens (Human))	BDBM50070865 ((2R,3R,4S,5R)-2-(2-Chloro-6-methoxyamino-purin-9-y...) Show SMILES CONc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)c1ccon1 Show InChI InChI=1S/C13H13ClN6O5/c1-23-19-10-6-11(17-13(14)16-10)20(4-15-6)12-8(22)7(21)9(25-12)5-2-3-24-18-5/h2-4,7-9,12,21-22H,1H3,(H,16,17,19)/t7-,8+,9+,12+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	31	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Binding affinity for adenosine A3 receptor as inhibition of [125I]-AB-MECA binding to human receptor expressed in HEK 293 cells				Bioorg Med Chem Lett 8: 1767-70 (1999) BindingDB Entry DOI: 10.7270/Q2PR7V3R
					More data for this Ligand-Target Pair
Adenosine receptor A3 (Homo sapiens (Human))	BDBM50070863 ((2S,3S,4R,5R)-5-(6-Benzylamino-purin-9-yl)-3,4-dih...) Show SMILES CNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NCc3ccccc3)ncnc12 Show InChI InChI=1S/C18H20N6O4/c1-19-17(27)14-12(25)13(26)18(28-14)24-9-23-11-15(21-8-22-16(11)24)20-7-10-5-3-2-4-6-10/h2-6,8-9,12-14,18,25-26H,7H2,1H3,(H,19,27)(H,20,21,22)/t12-,13+,14-,18+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	41	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Binding affinity for adenosine A3 receptor as inhibition of [125I]-AB-MECA binding to human receptor expressed in HEK 293 cells				Bioorg Med Chem Lett 8: 1767-70 (1999) BindingDB Entry DOI: 10.7270/Q2PR7V3R
					More data for this Ligand-Target Pair
Adenosine receptor A1 (Rattus norvegicus (rat))	BDBM21221 ((2S,3S,4R,5R)-5-(2-chloro-6-{[(3-iodophenyl)methyl...) Show SMILES CNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NCc3cccc(I)c3)nc(Cl)nc12 Show InChI InChI=1S/C18H18ClIN6O4/c1-21-16(29)13-11(27)12(28)17(30-13)26-7-23-10-14(24-18(19)25-15(10)26)22-6-8-3-2-4-9(20)5-8/h2-5,7,11-13,17,27-28H,6H2,1H3,(H,21,29)(H,22,24,25)/t11-,12+,13-,17+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	54	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Binding affinity for adenosine A1 receptor as inhibition of 3[H]-R-PIA binding in rat brain				Bioorg Med Chem Lett 8: 1767-70 (1999) BindingDB Entry DOI: 10.7270/Q2PR7V3R
					More data for this Ligand-Target Pair
Adenosine receptor A2a (Rattus norvegicus (rat))	BDBM21221 ((2S,3S,4R,5R)-5-(2-chloro-6-{[(3-iodophenyl)methyl...) Show SMILES CNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NCc3cccc(I)c3)nc(Cl)nc12 Show InChI InChI=1S/C18H18ClIN6O4/c1-21-16(29)13-11(27)12(28)17(30-13)26-7-23-10-14(24-18(19)25-15(10)26)22-6-8-3-2-4-9(20)5-8/h2-5,7,11-13,17,27-28H,6H2,1H3,(H,21,29)(H,22,24,25)/t11-,12+,13-,17+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	56	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Binding affinity for adenosine A2a receptor as inhibition of 3[H]-CGS 21680 binding in rat striatum				Bioorg Med Chem Lett 8: 1767-70 (1999) BindingDB Entry DOI: 10.7270/Q2PR7V3R
					More data for this Ligand-Target Pair
Adenosine receptor A1 (Rattus norvegicus (rat))	BDBM50070864 ((2R,3R,4S,5S)-2-(2-Chloro-6-methoxyamino-purin-9-y...) Show SMILES CONc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](CCl)[C@@H](O)[C@H]1O Show InChI InChI=1S/C11H13Cl2N5O4/c1-21-17-8-5-9(16-11(13)15-8)18(3-14-5)10-7(20)6(19)4(2-12)22-10/h3-4,6-7,10,19-20H,2H2,1H3,(H,15,16,17)/t4-,6-,7-,10-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	74	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Binding affinity for adenosine A1 receptor as inhibition of 3[H]-R-PIA binding in rat brain				Bioorg Med Chem Lett 8: 1767-70 (1999) BindingDB Entry DOI: 10.7270/Q2PR7V3R
					More data for this Ligand-Target Pair
Adenosine receptor A1 (Rattus norvegicus (rat))	BDBM50070865 ((2R,3R,4S,5R)-2-(2-Chloro-6-methoxyamino-purin-9-y...) Show SMILES CONc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)c1ccon1 Show InChI InChI=1S/C13H13ClN6O5/c1-23-19-10-6-11(17-13(14)16-10)20(4-15-6)12-8(22)7(21)9(25-12)5-2-3-24-18-5/h2-4,7-9,12,21-22H,1H3,(H,16,17,19)/t7-,8+,9+,12+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	620	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Binding affinity for adenosine A1 receptor as inhibition of 3[H]-R-PIA binding in rat brain				Bioorg Med Chem Lett 8: 1767-70 (1999) BindingDB Entry DOI: 10.7270/Q2PR7V3R
					More data for this Ligand-Target Pair
Adenosine receptor A1 (Rattus norvegicus (rat))	BDBM50070867 ((2R,3R,4S,5R)-2-(2-Chloro-6-methoxyamino-purin-9-y...) Show SMILES CONc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](C=C)[C@@H](O)[C@H]1O Show InChI InChI=1S/C12H14ClN5O4/c1-3-5-7(19)8(20)11(22-5)18-4-14-6-9(17-21-2)15-12(13)16-10(6)18/h3-5,7-8,11,19-20H,1H2,2H3,(H,15,16,17)/t5-,7-,8-,11-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	1.23E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Binding affinity for adenosine A1 receptor as inhibition of 3[H]-R-PIA binding in rat brain				Bioorg Med Chem Lett 8: 1767-70 (1999) BindingDB Entry DOI: 10.7270/Q2PR7V3R
					More data for this Ligand-Target Pair
Adenosine receptor A2a (Rattus norvegicus (rat))	BDBM50070866 ((2R,3R,4S,5R)-2-[2-Chloro-6-(3-iodo-benzylamino)-p...) Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1c1ccon1)n1cnc2c(NCc3cccc(I)c3)nc(Cl)nc12 Show InChI InChI=1S/C19H16ClIN6O4/c20-19-24-16(22-7-9-2-1-3-10(21)6-9)12-17(25-19)27(8-23-12)18-14(29)13(28)15(31-18)11-4-5-30-26-11/h1-6,8,13-15,18,28-29H,7H2,(H,22,24,25)/t13-,14+,15+,18+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Binding affinity for adenosine A2a receptor as inhibition of 3[H]-CGS 21680 binding in rat striatum				Bioorg Med Chem Lett 8: 1767-70 (1999) BindingDB Entry DOI: 10.7270/Q2PR7V3R
					More data for this Ligand-Target Pair
Adenosine receptor A1 (Rattus norvegicus (rat))	BDBM50070866 ((2R,3R,4S,5R)-2-[2-Chloro-6-(3-iodo-benzylamino)-p...) Show SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1c1ccon1)n1cnc2c(NCc3cccc(I)c3)nc(Cl)nc12 Show InChI InChI=1S/C19H16ClIN6O4/c20-19-24-16(22-7-9-2-1-3-10(21)6-9)12-17(25-19)27(8-23-12)18-14(29)13(28)15(31-18)11-4-5-30-26-11/h1-6,8,13-15,18,28-29H,7H2,(H,22,24,25)/t13-,14+,15+,18+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Binding affinity for adenosine A1 receptor as inhibition of 3[H]-R-PIA binding in rat brain				Bioorg Med Chem Lett 8: 1767-70 (1999) BindingDB Entry DOI: 10.7270/Q2PR7V3R
					More data for this Ligand-Target Pair
Adenosine receptor A2a (Rattus norvegicus (rat))	BDBM50070863 ((2S,3S,4R,5R)-5-(6-Benzylamino-purin-9-yl)-3,4-dih...) Show SMILES CNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NCc3ccccc3)ncnc12 Show InChI InChI=1S/C18H20N6O4/c1-19-17(27)14-12(25)13(26)18(28-14)24-9-23-11-15(21-8-22-16(11)24)20-7-10-5-3-2-4-6-10/h2-6,8-9,12-14,18,25-26H,7H2,1H3,(H,19,27)(H,20,21,22)/t12-,13+,14-,18+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Binding affinity for adenosine A2a receptor as inhibition of 3[H]-CGS 21680 binding in rat striatum				Bioorg Med Chem Lett 8: 1767-70 (1999) BindingDB Entry DOI: 10.7270/Q2PR7V3R
					More data for this Ligand-Target Pair
Adenosine receptor A1 (Rattus norvegicus (rat))	BDBM50070863 ((2S,3S,4R,5R)-5-(6-Benzylamino-purin-9-yl)-3,4-dih...) Show SMILES CNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NCc3ccccc3)ncnc12 Show InChI InChI=1S/C18H20N6O4/c1-19-17(27)14-12(25)13(26)18(28-14)24-9-23-11-15(21-8-22-16(11)24)20-7-10-5-3-2-4-6-10/h2-6,8-9,12-14,18,25-26H,7H2,1H3,(H,19,27)(H,20,21,22)/t12-,13+,14-,18+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Binding affinity for adenosine A1 receptor as inhibition of 3[H]-R-PIA binding in rat brain				Bioorg Med Chem Lett 8: 1767-70 (1999) BindingDB Entry DOI: 10.7270/Q2PR7V3R
					More data for this Ligand-Target Pair
Adenosine receptor A2a (Rattus norvegicus (rat))	BDBM50070864 ((2R,3R,4S,5S)-2-(2-Chloro-6-methoxyamino-purin-9-y...) Show SMILES CONc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](CCl)[C@@H](O)[C@H]1O Show InChI InChI=1S/C11H13Cl2N5O4/c1-21-17-8-5-9(16-11(13)15-8)18(3-14-5)10-7(20)6(19)4(2-12)22-10/h3-4,6-7,10,19-20H,2H2,1H3,(H,15,16,17)/t4-,6-,7-,10-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	4.65E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Binding affinity for adenosine A2a receptor as inhibition of 3[H]-CGS 21680 binding in rat striatum				Bioorg Med Chem Lett 8: 1767-70 (1999) BindingDB Entry DOI: 10.7270/Q2PR7V3R
					More data for this Ligand-Target Pair
Adenosine receptor A2a (Rattus norvegicus (rat))	BDBM50070865 ((2R,3R,4S,5R)-2-(2-Chloro-6-methoxyamino-purin-9-y...) Show SMILES CONc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)c1ccon1 Show InChI InChI=1S/C13H13ClN6O5/c1-23-19-10-6-11(17-13(14)16-10)20(4-15-6)12-8(22)7(21)9(25-12)5-2-3-24-18-5/h2-4,7-9,12,21-22H,1H3,(H,16,17,19)/t7-,8+,9+,12+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Binding affinity for adenosine A2a receptor as inhibition of 3[H]-CGS 21680 binding in rat striatum				Bioorg Med Chem Lett 8: 1767-70 (1999) BindingDB Entry DOI: 10.7270/Q2PR7V3R
					More data for this Ligand-Target Pair
Adenosine receptor A2a (Rattus norvegicus (rat))	BDBM50070867 ((2R,3R,4S,5R)-2-(2-Chloro-6-methoxyamino-purin-9-y...) Show SMILES CONc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](C=C)[C@@H](O)[C@H]1O Show InChI InChI=1S/C12H14ClN5O4/c1-3-5-7(19)8(20)11(22-5)18-4-14-6-9(17-21-2)15-12(13)16-10(6)18/h3-5,7-8,11,19-20H,1H2,2H3,(H,15,16,17)/t5-,7-,8-,11-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Binding affinity for adenosine A2a receptor as inhibition of 3[H]-CGS 21680 binding in rat striatum				Bioorg Med Chem Lett 8: 1767-70 (1999) BindingDB Entry DOI: 10.7270/Q2PR7V3R
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50130727 (1-(4-Amino-furazan-3-yl)-5-pyrrolidin-1-ylmethyl-1...) Show SMILES Nc1nonc1-n1nnc(C(=O)N\N=C\c2ccncc2)c1CN1CCCC1 Show InChI InChI=1S/C16H18N10O2/c17-14-15(23-28-22-14)26-12(10-25-7-1-2-8-25)13(20-24-26)16(27)21-19-9-11-3-5-18-6-4-11/h3-6,9H,1-2,7-8,10H2,(H2,17,22)(H,21,27)/b19-9+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Inhibitory activity against human glycogen synthase kinase-3beta (GSK3-beta) at 100 uM ATP				J Med Chem 46: 3333-41 (2003) Article DOI: 10.1021/jm021095d BindingDB Entry DOI: 10.7270/Q2F76D9B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50130724 (1-(4-Amino-furazan-3-yl)-5-piperidin-1-ylmethyl-1H...) Show SMILES Nc1nonc1-n1nnc(C(=O)N\N=C\c2ccncc2)c1CN1CCCCC1 Show InChI InChI=1S/C17H20N10O2/c18-15-16(24-29-23-15)27-13(11-26-8-2-1-3-9-26)14(21-25-27)17(28)22-20-10-12-4-6-19-7-5-12/h4-7,10H,1-3,8-9,11H2,(H2,18,23)(H,22,28)/b20-10+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Inhibitory activity against human glycogen synthase kinase-3beta (GSK3-beta) at 100 uM ATP				J Med Chem 46: 3333-41 (2003) Article DOI: 10.1021/jm021095d BindingDB Entry DOI: 10.7270/Q2F76D9B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50059889 ((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...) Show SMILES CN[C@@H]1CC2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20?,26-,28+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Inhibitory activity against human glycogen synthase kinase-3beta (GSK3-beta) at 100 uM ATP				J Med Chem 46: 3333-41 (2003) Article DOI: 10.1021/jm021095d BindingDB Entry DOI: 10.7270/Q2F76D9B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50130732 (4-[4-(5-Pyridin-4-yl-4H-[1,2,4]triazol-3-yl)-5-pyr...) Show SMILES Nc1nonc1-n1nnc(-c2nnc([nH]2)-c2ccncc2)c1CN1CCCC1 Show InChI InChI=1S/C16H17N11O/c17-13-16(24-28-23-13)27-11(9-26-7-1-2-8-26)12(20-25-27)15-19-14(21-22-15)10-3-5-18-6-4-10/h3-6H,1-2,7-9H2,(H2,17,23)(H,19,21,22)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Inhibitory activity against human glycogen synthase kinase-3beta (GSK3-beta) at 100 uM ATP				J Med Chem 46: 3333-41 (2003) Article DOI: 10.1021/jm021095d BindingDB Entry DOI: 10.7270/Q2F76D9B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50130719 (4-[5-Piperidin-1-ylmethyl-4-(5-pyridin-4-yl-4H-[1,...) Show SMILES Nc1nonc1-n1nnc(-c2nnc([nH]2)-c2ccncc2)c1CN1CCCCC1 Show InChI InChI=1S/C17H19N11O/c18-14-17(25-29-24-14)28-12(10-27-8-2-1-3-9-27)13(21-26-28)16-20-15(22-23-16)11-4-6-19-7-5-11/h4-7H,1-3,8-10H2,(H2,18,24)(H,20,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Inhibitory activity against human glycogen synthase kinase-3beta (GSK3-beta) at 100 uM ATP				J Med Chem 46: 3333-41 (2003) Article DOI: 10.1021/jm021095d BindingDB Entry DOI: 10.7270/Q2F76D9B
					More data for this Ligand-Target Pair
Cyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50130725 (3-(3-Chloro-4-hydroxy-phenylamino)-4-(2-nitro-phen...) Show SMILES Oc1ccc(NC2=C(C(=O)NC2=O)c2ccccc2[N+]([O-])=O)cc1Cl |t:6| Show InChI InChI=1S/C16H10ClN3O5/c17-10-7-8(5-6-12(10)21)18-14-13(15(22)19-16(14)23)9-3-1-2-4-11(9)20(24)25/h1-7,21H,(H2,18,19,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Inhibition of Cyclin-dependent kinase 2-cyclin A				J Med Chem 46: 3333-41 (2003) Article DOI: 10.1021/jm021095d BindingDB Entry DOI: 10.7270/Q2F76D9B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50130725 (3-(3-Chloro-4-hydroxy-phenylamino)-4-(2-nitro-phen...) Show SMILES Oc1ccc(NC2=C(C(=O)NC2=O)c2ccccc2[N+]([O-])=O)cc1Cl |t:6| Show InChI InChI=1S/C16H10ClN3O5/c17-10-7-8(5-6-12(10)21)18-14-13(15(22)19-16(14)23)9-3-1-2-4-11(9)20(24)25/h1-7,21H,(H2,18,19,22,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Inhibitory activity against human glycogen synthase kinase-3beta (GSK3-beta) at 100 uM ATP				J Med Chem 46: 3333-41 (2003) Article DOI: 10.1021/jm021095d BindingDB Entry DOI: 10.7270/Q2F76D9B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50130730 (1-(4-Amino-furazan-3-yl)-5-diethylaminomethyl-1H-[...) Show SMILES CCN(CC)Cc1c(nnn1-c1nonc1N)C(=O)N\N=C\c1ccncc1 Show InChI InChI=1S/C16H20N10O2/c1-3-25(4-2)10-12-13(20-24-26(12)15-14(17)22-28-23-15)16(27)21-19-9-11-5-7-18-8-6-11/h5-9H,3-4,10H2,1-2H3,(H2,17,22)(H,21,27)/b19-9+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	410	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Inhibitory activity against human glycogen synthase kinase-3beta (GSK3-beta) at 100 uM ATP				J Med Chem 46: 3333-41 (2003) Article DOI: 10.1021/jm021095d BindingDB Entry DOI: 10.7270/Q2F76D9B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50130720 (1-(4-Amino-furazan-3-yl)-5-piperidin-1-ylmethyl-1H...) Show SMILES Nc1nonc1-n1nnc(C(=O)NCCc2ccncc2)c1CN1CCCCC1 Show InChI InChI=1S/C18H23N9O2/c19-16-17(24-29-23-16)27-14(12-26-10-2-1-3-11-26)15(22-25-27)18(28)21-9-6-13-4-7-20-8-5-13/h4-5,7-8H,1-3,6,9-12H2,(H2,19,23)(H,21,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.16E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Inhibitory activity against human glycogen synthase kinase-3beta (GSK3-beta) at 100 uM ATP				J Med Chem 46: 3333-41 (2003) Article DOI: 10.1021/jm021095d BindingDB Entry DOI: 10.7270/Q2F76D9B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50130726 (1-(4-Amino-furazan-3-yl)-5-pyrrolidin-1-ylmethyl-1...) Show SMILES Nc1nonc1-n1nnc(C(=O)NCCc2ccncc2)c1CN1CCCC1 Show InChI InChI=1S/C17H21N9O2/c18-15-16(23-28-22-15)26-13(11-25-9-1-2-10-25)14(21-24-26)17(27)20-8-5-12-3-6-19-7-4-12/h3-4,6-7H,1-2,5,8-11H2,(H2,18,22)(H,20,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Inhibitory activity against human glycogen synthase kinase-3beta (GSK3-beta) at 100 uM ATP				J Med Chem 46: 3333-41 (2003) Article DOI: 10.1021/jm021095d BindingDB Entry DOI: 10.7270/Q2F76D9B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50130722 (4-[5-Dimethylaminomethyl-4-(5-pyridin-4-yl-4H-[1,2...) Show SMILES CN(C)Cc1c(nnn1-c1nonc1N)-c1nnc([nH]1)-c1ccncc1 Show InChI InChI=1S/C14H15N11O/c1-24(2)7-9-10(18-23-25(9)14-11(15)21-26-22-14)13-17-12(19-20-13)8-3-5-16-6-4-8/h3-6H,7H2,1-2H3,(H2,15,21)(H,17,19,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.92E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Inhibitory activity against human glycogen synthase kinase-3beta (GSK3-beta) at 100 uM ATP				J Med Chem 46: 3333-41 (2003) Article DOI: 10.1021/jm021095d BindingDB Entry DOI: 10.7270/Q2F76D9B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50130733 (1-(4-Amino-furazan-3-yl)-5-piperidin-1-ylmethyl-1H...) Show SMILES Nc1nonc1-n1nnc(C(=O)NCc2ccncc2)c1CN1CCCCC1 Show InChI InChI=1S/C17H21N9O2/c18-15-16(23-28-22-15)26-13(11-25-8-2-1-3-9-25)14(21-24-26)17(27)20-10-12-4-6-19-7-5-12/h4-7H,1-3,8-11H2,(H2,18,22)(H,20,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Inhibitory activity against human glycogen synthase kinase-3beta (GSK3-beta) at 100 uM ATP				J Med Chem 46: 3333-41 (2003) Article DOI: 10.1021/jm021095d BindingDB Entry DOI: 10.7270/Q2F76D9B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50130731 (1-(4-Amino-furazan-3-yl)-5-piperidin-1-ylmethyl-1H...) Show SMILES NNC(=O)c1nnn(c1CN1CCCCC1)-c1nonc1N Show InChI InChI=1S/C11H17N9O2/c12-9-10(17-22-16-9)20-7(6-19-4-2-1-3-5-19)8(15-18-20)11(21)14-13/h1-6,13H2,(H2,12,16)(H,14,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Inhibitory activity against human glycogen synthase kinase-3beta (GSK3-beta) at 100 uM ATP				J Med Chem 46: 3333-41 (2003) Article DOI: 10.1021/jm021095d BindingDB Entry DOI: 10.7270/Q2F76D9B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50130728 (1-(4-Amino-furazan-3-yl)-5-diethylaminomethyl-1H-[...) Show SMILES CCN(CC)Cc1c(nnn1-c1nonc1N)C(=O)NCCc1ccncc1 Show InChI InChI=1S/C17H23N9O2/c1-3-25(4-2)11-13-14(21-24-26(13)16-15(18)22-28-23-16)17(27)20-10-7-12-5-8-19-9-6-12/h5-6,8-9H,3-4,7,10-11H2,1-2H3,(H2,18,22)(H,20,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.17E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Inhibitory activity against human glycogen synthase kinase-3beta (GSK3-beta) at 100 uM ATP				J Med Chem 46: 3333-41 (2003) Article DOI: 10.1021/jm021095d BindingDB Entry DOI: 10.7270/Q2F76D9B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50130721 (1-(4-Amino-furazan-3-yl)-5-diethylaminomethyl-1H-[...) Show SMILES CCN(CC)Cc1c(nnn1-c1nonc1N)C(=O)NN Show InChI InChI=1S/C10H17N9O2/c1-3-18(4-2)5-6-7(10(20)13-12)14-17-19(6)9-8(11)15-21-16-9/h3-5,12H2,1-2H3,(H2,11,15)(H,13,20)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Inhibition of human Glycogen synthase kinase-3 beta (GSK3-beta) at 100 uM ATP				J Med Chem 46: 3333-41 (2003) Article DOI: 10.1021/jm021095d BindingDB Entry DOI: 10.7270/Q2F76D9B
					More data for this Ligand-Target Pair
Cyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50130724 (1-(4-Amino-furazan-3-yl)-5-piperidin-1-ylmethyl-1H...) Show SMILES Nc1nonc1-n1nnc(C(=O)N\N=C\c2ccncc2)c1CN1CCCCC1 Show InChI InChI=1S/C17H20N10O2/c18-15-16(24-29-23-15)27-13(11-26-8-2-1-3-9-26)14(21-25-27)17(28)22-20-10-12-4-6-19-7-5-12/h4-7,10H,1-3,8-9,11H2,(H2,18,23)(H,22,28)/b20-10+	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Inhibition of Cyclin-dependent kinase 2-cyclin A				J Med Chem 46: 3333-41 (2003) Article DOI: 10.1021/jm021095d BindingDB Entry DOI: 10.7270/Q2F76D9B
					More data for this Ligand-Target Pair
Cyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50130720 (1-(4-Amino-furazan-3-yl)-5-piperidin-1-ylmethyl-1H...) Show SMILES Nc1nonc1-n1nnc(C(=O)NCCc2ccncc2)c1CN1CCCCC1 Show InChI InChI=1S/C18H23N9O2/c19-16-17(24-29-23-16)27-14(12-26-10-2-1-3-11-26)15(22-25-27)18(28)21-9-6-13-4-7-20-8-5-13/h4-5,7-8H,1-3,6,9-12H2,(H2,19,23)(H,21,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.19E+5	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Inhibition of Cyclin-dependent kinase 2-cyclin A				J Med Chem 46: 3333-41 (2003) Article DOI: 10.1021/jm021095d BindingDB Entry DOI: 10.7270/Q2F76D9B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50130729 (1-(4-Amino-furazan-3-yl)-5-(isobutylamino-methyl)-...) Show SMILES CC(C)CNCc1c(nnn1-c1nonc1N)C(=O)NCc1ccncc1 Show InChI InChI=1S/C16H21N9O2/c1-10(2)7-19-9-12-13(16(26)20-8-11-3-5-18-6-4-11)21-24-25(12)15-14(17)22-27-23-15/h3-6,10,19H,7-9H2,1-2H3,(H2,17,22)(H,20,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Inhibitory activity against human glycogen synthase kinase-3beta (GSK3-beta) at 100 uM ATP				J Med Chem 46: 3333-41 (2003) Article DOI: 10.1021/jm021095d BindingDB Entry DOI: 10.7270/Q2F76D9B
					More data for this Ligand-Target Pair
Cyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2 (Homo sapiens (Human))	BDBM50130719 (4-[5-Piperidin-1-ylmethyl-4-(5-pyridin-4-yl-4H-[1,...) Show SMILES Nc1nonc1-n1nnc(-c2nnc([nH]2)-c2ccncc2)c1CN1CCCCC1 Show InChI InChI=1S/C17H19N11O/c18-14-17(25-29-24-14)28-12(10-27-8-2-1-3-9-27)13(21-26-28)16-20-15(22-23-16)11-4-6-19-7-5-11/h4-7H,1-3,8-10H2,(H2,18,24)(H,20,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Inhibition of Cyclin-dependent kinase 2-cyclin A				J Med Chem 46: 3333-41 (2003) Article DOI: 10.1021/jm021095d BindingDB Entry DOI: 10.7270/Q2F76D9B
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Homo sapiens (Human))	BDBM50130723 (1-(4-Amino-furazan-3-yl)-5-piperidin-1-ylmethyl-1H...) Show SMILES CN(CCc1ccncc1)C(=O)c1nnn(c1CN1CCCCC1)-c1nonc1N Show InChI InChI=1S/C19H25N9O2/c1-26(12-7-14-5-8-21-9-6-14)19(29)16-15(13-27-10-3-2-4-11-27)28(25-22-16)18-17(20)23-30-24-18/h5-6,8-9H,2-4,7,10-13H2,1H3,(H2,20,23)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.50E+5	n/a	n/a	n/a	n/a	n/a	n/a
Novo Nordisk A/S Curated by ChEMBL					Assay Description Inhibitory activity against human glycogen synthase kinase-3beta (GSK3-beta) at 100 uM ATP				J Med Chem 46: 3333-41 (2003) Article DOI: 10.1021/jm021095d BindingDB Entry DOI: 10.7270/Q2F76D9B
					More data for this Ligand-Target Pair