Found 44 hits with Last Name = 'stubbs' and Initial = 'cj' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50023342
![PNG](/data/jpeg/tenK5002/BindingDB_50023342.png) (CHEMBL3334567)Show SMILES C[C@@H](c1ccc2nccn2c1)n1nnc2ncc(nc12)-c1cnn(C)c1 |r| Show InChI InChI=1S/C17H15N9/c1-11(12-3-4-15-18-5-6-25(15)10-12)26-17-16(22-23-26)19-8-14(21-17)13-7-20-24(2)9-13/h3-11H,1-2H3/t11-/m0/s1 | PDB MMDB
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UniProtKB/SwissProt
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| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of c-Met phosphorylation at Tyr 1234/Tyr1235 residues in human NCI-H1993 cells incubated for 4 hrs by HTRF assay |
ACS Med Chem Lett 10: 1322-1327 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00276 BindingDB Entry DOI: 10.7270/Q27W6GKF |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50306682
![PNG](/data/jpeg/tenK5030/BindingDB_50306682.png) ((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)Show SMILES C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl |r| Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1 | PDB MMDB
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| n/a | n/a | >2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of wild type N-terminal NH-tagged and avi-tagged dephosphorylated c-MET (956 to 1390 residues) (unknown origin) expressed in sf21 cells us... |
ACS Med Chem Lett 10: 1322-1327 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00276 BindingDB Entry DOI: 10.7270/Q27W6GKF |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50023342
![PNG](/data/jpeg/tenK5002/BindingDB_50023342.png) (CHEMBL3334567)Show SMILES C[C@@H](c1ccc2nccn2c1)n1nnc2ncc(nc12)-c1cnn(C)c1 |r| Show InChI InChI=1S/C17H15N9/c1-11(12-3-4-15-18-5-6-25(15)10-12)26-17-16(22-23-26)19-8-14(21-17)13-7-20-24(2)9-13/h3-11H,1-2H3/t11-/m0/s1 | PDB MMDB
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| PDB Article PubMed
| n/a | n/a | >2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of wild type N-terminal NH-tagged and avi-tagged dephosphorylated c-MET (956 to 1390 residues) (unknown origin) expressed in sf21 cells us... |
ACS Med Chem Lett 10: 1322-1327 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00276 BindingDB Entry DOI: 10.7270/Q27W6GKF |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50399540
![PNG](/data/jpeg/tenK5039/BindingDB_50399540.png) (FORETINIB | US10464902, Foretinib | US10882853, Co...)Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42) | PDB MMDB
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| n/a | n/a | >2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of N-terminal NH-tagged and avi-tagged dephosphorylated c-MET D1228V mutant (956 to 1390 residues) (unknown origin) expressed in sf21 cell... |
ACS Med Chem Lett 10: 1322-1327 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00276 BindingDB Entry DOI: 10.7270/Q27W6GKF |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM28031
![PNG](/data/jpeg/tenK2/BindingDB_28031.png) (BMS-777607 | N-{4-[(2-amino-3-chloropyridin-4-yl)o...)Show SMILES CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc(N)c2Cl)c(F)c1 Show InChI InChI=1S/C25H19ClF2N4O4/c1-2-35-19-10-12-32(16-6-3-14(27)4-7-16)25(34)21(19)24(33)31-15-5-8-18(17(28)13-15)36-20-9-11-30-23(29)22(20)26/h3-13H,2H2,1H3,(H2,29,30)(H,31,33) | PDB MMDB
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| n/a | n/a | >2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of wild type N-terminal NH-tagged and avi-tagged dephosphorylated c-MET (956 to 1390 residues) (unknown origin) expressed in sf21 cells us... |
ACS Med Chem Lett 10: 1322-1327 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00276 BindingDB Entry DOI: 10.7270/Q27W6GKF |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50306682
![PNG](/data/jpeg/tenK5030/BindingDB_50306682.png) ((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)Show SMILES C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl |r| Show InChI InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1 | PDB MMDB
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| PDB Article PubMed
| n/a | n/a | >2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of N-terminal NH-tagged and avi-tagged dephosphorylated c-MET D1228V mutant (956 to 1390 residues) (unknown origin) expressed in sf21 cell... |
ACS Med Chem Lett 10: 1322-1327 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00276 BindingDB Entry DOI: 10.7270/Q27W6GKF |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM28031
![PNG](/data/jpeg/tenK2/BindingDB_28031.png) (BMS-777607 | N-{4-[(2-amino-3-chloropyridin-4-yl)o...)Show SMILES CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc(N)c2Cl)c(F)c1 Show InChI InChI=1S/C25H19ClF2N4O4/c1-2-35-19-10-12-32(16-6-3-14(27)4-7-16)25(34)21(19)24(33)31-15-5-8-18(17(28)13-15)36-20-9-11-30-23(29)22(20)26/h3-13H,2H2,1H3,(H2,29,30)(H,31,33) | PDB MMDB
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| n/a | n/a | >2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of N-terminal NH-tagged and avi-tagged dephosphorylated c-MET D1228V mutant (956 to 1390 residues) (unknown origin) expressed in sf21 cell... |
ACS Med Chem Lett 10: 1322-1327 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00276 BindingDB Entry DOI: 10.7270/Q27W6GKF |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50399540
![PNG](/data/jpeg/tenK5039/BindingDB_50399540.png) (FORETINIB | US10464902, Foretinib | US10882853, Co...)Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42) | PDB MMDB
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| n/a | n/a | >2.5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of wild type N-terminal NH-tagged and avi-tagged dephosphorylated c-MET (956 to 1390 residues) (unknown origin) expressed in sf21 cells us... |
ACS Med Chem Lett 10: 1322-1327 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00276 BindingDB Entry DOI: 10.7270/Q27W6GKF |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50549946
![PNG](/data/jpeg/tenK5054/BindingDB_50549946.png) (CHEMBL4796908)Show SMILES Fc1ccccc1Cc1c[nH]c2ncc(cc12)-c1cnn(c1)C1CCNCC1 | PDB MMDB
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UniProtKB/SwissProt
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| PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of wild type N-terminal NH-tagged and avi-tagged dephosphorylated human c-MET (956 to 1390 residues) expressed in Sf21 cells using poly (G... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00392 BindingDB Entry DOI: 10.7270/Q20C50DP |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50549945
![PNG](/data/jpeg/tenK5054/BindingDB_50549945.png) (CHEMBL4784342)Show SMILES C(c1c[nH]c2ncc(cc12)-c1cnn(c1)C1CCNCC1)c1ccccc1 | PDB MMDB
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UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of wild type N-terminal NH-tagged and avi-tagged dephosphorylated human c-MET (956 to 1390 residues) expressed in Sf21 cells using poly (G... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00392 BindingDB Entry DOI: 10.7270/Q20C50DP |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50549947
![PNG](/data/jpeg/tenK5054/BindingDB_50549947.png) (CHEMBL4749560)Show SMILES Fc1cccc(Cc2c[nH]c3ncc(cc23)-c2cnn(c2)C2CCNCC2)c1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of wild type N-terminal NH-tagged and avi-tagged dephosphorylated human c-MET (956 to 1390 residues) expressed in Sf21 cells using poly (G... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00392 BindingDB Entry DOI: 10.7270/Q20C50DP |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50609348
![PNG](/data/jpeg/tenK5060/BindingDB_50609348.png) (CHEMBL5272595)Show SMILES CN([C@@H]1CCCc2c(ccc(C)c12)-c1ccc2c(C)n[nH]c2c1)C(=O)c1ncccc1C(F)F |r| | PDB MMDB
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UniProtKB/SwissProt
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| PC cid PC sid PDB UniChem
| PDB
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50549948
![PNG](/data/jpeg/tenK5054/BindingDB_50549948.png) (CHEMBL4792886)Show SMILES Fc1ccc(Cc2c[nH]c3ncc(cc23)-c2cnn(c2)C2CCNCC2)cc1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 137 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of wild type N-terminal NH-tagged and avi-tagged dephosphorylated human c-MET (956 to 1390 residues) expressed in Sf21 cells using poly (G... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00392 BindingDB Entry DOI: 10.7270/Q20C50DP |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM28031
![PNG](/data/jpeg/tenK2/BindingDB_28031.png) (BMS-777607 | N-{4-[(2-amino-3-chloropyridin-4-yl)o...)Show SMILES CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc(N)c2Cl)c(F)c1 Show InChI InChI=1S/C25H19ClF2N4O4/c1-2-35-19-10-12-32(16-6-3-14(27)4-7-16)25(34)21(19)24(33)31-15-5-8-18(17(28)13-15)36-20-9-11-30-23(29)22(20)26/h3-13H,2H2,1H3,(H2,29,30)(H,31,33) | PDB MMDB
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| PDB Article PubMed
| n/a | n/a | 214 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of c-Met phosphorylation at Tyr 1234/Tyr1235 residues in human NCI-H1993 cells incubated for 4 hrs by HTRF assay |
ACS Med Chem Lett 10: 1322-1327 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00276 BindingDB Entry DOI: 10.7270/Q27W6GKF |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM28031
![PNG](/data/jpeg/tenK2/BindingDB_28031.png) (BMS-777607 | N-{4-[(2-amino-3-chloropyridin-4-yl)o...)Show SMILES CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc(N)c2Cl)c(F)c1 Show InChI InChI=1S/C25H19ClF2N4O4/c1-2-35-19-10-12-32(16-6-3-14(27)4-7-16)25(34)21(19)24(33)31-15-5-8-18(17(28)13-15)36-20-9-11-30-23(29)22(20)26/h3-13H,2H2,1H3,(H2,29,30)(H,31,33) | PDB MMDB
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| PDB Article PubMed
| n/a | n/a | 214 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of c-MET D1228V mutant phosphorylation at Tyr1234/Tyr1235 residues in CRISPR/Cas9 modified human NCI-H1993 cells incubated for 4 hrs by HT... |
ACS Med Chem Lett 10: 1322-1327 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00276 BindingDB Entry DOI: 10.7270/Q27W6GKF |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50399540
![PNG](/data/jpeg/tenK5039/BindingDB_50399540.png) (FORETINIB | US10464902, Foretinib | US10882853, Co...)Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42) | PDB MMDB
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Similars
| PDB Article PubMed
| n/a | n/a | 214 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of c-Met phosphorylation at Tyr 1234/Tyr1235 residues in human NCI-H1993 cells incubated for 4 hrs by HTRF assay |
ACS Med Chem Lett 10: 1322-1327 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00276 BindingDB Entry DOI: 10.7270/Q27W6GKF |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50399540
![PNG](/data/jpeg/tenK5039/BindingDB_50399540.png) (FORETINIB | US10464902, Foretinib | US10882853, Co...)Show SMILES COc1cc2c(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C34H34F2N4O6/c1-43-30-20-25-27(21-31(30)45-16-2-13-40-14-17-44-18-15-40)37-12-9-28(25)46-29-8-7-24(19-26(29)36)39-33(42)34(10-11-34)32(41)38-23-5-3-22(35)4-6-23/h3-9,12,19-21H,2,10-11,13-18H2,1H3,(H,38,41)(H,39,42) | PDB MMDB
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Similars
| PDB Article PubMed
| n/a | n/a | 214 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of c-MET D1228V mutant phosphorylation at Tyr1234/Tyr1235 residues in CRISPR/Cas9 modified human NCI-H1993 cells incubated for 4 hrs by HT... |
ACS Med Chem Lett 10: 1322-1327 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00276 BindingDB Entry DOI: 10.7270/Q27W6GKF |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50549944
![PNG](/data/jpeg/tenK5054/BindingDB_50549944.png) (CHEMBL4747073)Show SMILES O=C1NCc2c(c[nH]c12)-c1cnc2[nH]cc(Cc3ccccc3)c2c1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 660 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of wild type N-terminal NH-tagged and avi-tagged dephosphorylated human c-MET (956 to 1390 residues) expressed in Sf21 cells using poly (G... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00392 BindingDB Entry DOI: 10.7270/Q20C50DP |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50023342
![PNG](/data/jpeg/tenK5002/BindingDB_50023342.png) (CHEMBL3334567)Show SMILES C[C@@H](c1ccc2nccn2c1)n1nnc2ncc(nc12)-c1cnn(C)c1 |r| Show InChI InChI=1S/C17H15N9/c1-11(12-3-4-15-18-5-6-25(15)10-12)26-17-16(22-23-26)19-8-14(21-17)13-7-20-24(2)9-13/h3-11H,1-2H3/t11-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 676 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of N-terminal NH-tagged and avi-tagged dephosphorylated c-MET D1228V mutant (956 to 1390 residues) (unknown origin) expressed in sf21 cell... |
ACS Med Chem Lett 10: 1322-1327 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00276 BindingDB Entry DOI: 10.7270/Q27W6GKF |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50609348
![PNG](/data/jpeg/tenK5060/BindingDB_50609348.png) (CHEMBL5272595)Show SMILES CN([C@@H]1CCCc2c(ccc(C)c12)-c1ccc2c(C)n[nH]c2c1)C(=O)c1ncccc1C(F)F |r| | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid PDB UniChem
| PDB
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50549946
![PNG](/data/jpeg/tenK5054/BindingDB_50549946.png) (CHEMBL4796908)Show SMILES Fc1ccccc1Cc1c[nH]c2ncc(cc12)-c1cnn(c1)C1CCNCC1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 1.88E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of c-Met phosphorylation at Tyr 1234/Tyr1235 residues in human NCI-H1993 cells incubated for 4 hrs by HTRF assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00392 BindingDB Entry DOI: 10.7270/Q20C50DP |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50549942
![PNG](/data/jpeg/tenK5054/BindingDB_50549942.png) (CHEMBL4748121) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of wild type N-terminal NH-tagged and avi-tagged dephosphorylated human c-MET (956 to 1390 residues) expressed in Sf21 cells using poly (G... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00392 BindingDB Entry DOI: 10.7270/Q20C50DP |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50549947
![PNG](/data/jpeg/tenK5054/BindingDB_50549947.png) (CHEMBL4749560)Show SMILES Fc1cccc(Cc2c[nH]c3ncc(cc23)-c2cnn(c2)C2CCNCC2)c1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 3.12E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of c-Met phosphorylation at Tyr 1234/Tyr1235 residues in human NCI-H1993 cells incubated for 4 hrs by HTRF assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00392 BindingDB Entry DOI: 10.7270/Q20C50DP |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50549948
![PNG](/data/jpeg/tenK5054/BindingDB_50549948.png) (CHEMBL4792886)Show SMILES Fc1ccc(Cc2c[nH]c3ncc(cc23)-c2cnn(c2)C2CCNCC2)cc1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 4.71E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of c-Met phosphorylation at Tyr 1234/Tyr1235 residues in human NCI-H1993 cells incubated for 4 hrs by HTRF assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00392 BindingDB Entry DOI: 10.7270/Q20C50DP |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50609349
![PNG](/data/jpeg/tenK5060/BindingDB_50609349.png) (CHEMBL5283603)Show SMILES CN([C@H]1CCCc2c(ccc(C)c12)-c1ccc2c(C)n[nH]c2c1)C(=O)c1ncccc1C(F)F |r| | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 4.94E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50549945
![PNG](/data/jpeg/tenK5054/BindingDB_50549945.png) (CHEMBL4784342)Show SMILES C(c1c[nH]c2ncc(cc12)-c1cnn(c1)C1CCNCC1)c1ccccc1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 5.94E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of c-Met phosphorylation at Tyr 1234/Tyr1235 residues in human NCI-H1993 cells incubated for 4 hrs by HTRF assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00392 BindingDB Entry DOI: 10.7270/Q20C50DP |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50549943
![PNG](/data/jpeg/tenK5054/BindingDB_50549943.png) (CHEMBL4743552) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 9.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of wild type N-terminal NH-tagged and avi-tagged dephosphorylated human c-MET (956 to 1390 residues) expressed in Sf21 cells using poly (G... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00392 BindingDB Entry DOI: 10.7270/Q20C50DP |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50609349
![PNG](/data/jpeg/tenK5060/BindingDB_50609349.png) (CHEMBL5283603)Show SMILES CN([C@H]1CCCc2c(ccc(C)c12)-c1ccc2c(C)n[nH]c2c1)C(=O)c1ncccc1C(F)F |r| | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50609348
![PNG](/data/jpeg/tenK5060/BindingDB_50609348.png) (CHEMBL5272595)Show SMILES CN([C@@H]1CCCc2c(ccc(C)c12)-c1ccc2c(C)n[nH]c2c1)C(=O)c1ncccc1C(F)F |r| | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid PDB UniChem
| PDB
| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50549944
![PNG](/data/jpeg/tenK5054/BindingDB_50549944.png) (CHEMBL4747073)Show SMILES O=C1NCc2c(c[nH]c12)-c1cnc2[nH]cc(Cc3ccccc3)c2c1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 2.19E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of c-Met phosphorylation at Tyr 1234/Tyr1235 residues in human NCI-H1993 cells incubated for 4 hrs by HTRF assay |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00392 BindingDB Entry DOI: 10.7270/Q20C50DP |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50549941
![PNG](/data/jpeg/tenK5054/BindingDB_50549941.png) (CHEMBL4744343) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 2.42E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of wild type N-terminal NH-tagged and avi-tagged dephosphorylated human c-MET (956 to 1390 residues) expressed in Sf21 cells using poly (G... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00392 BindingDB Entry DOI: 10.7270/Q20C50DP |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50609348
![PNG](/data/jpeg/tenK5060/BindingDB_50609348.png) (CHEMBL5272595)Show SMILES CN([C@@H]1CCCc2c(ccc(C)c12)-c1ccc2c(C)n[nH]c2c1)C(=O)c1ncccc1C(F)F |r| | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid PDB UniChem
| PDB
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50023342
![PNG](/data/jpeg/tenK5002/BindingDB_50023342.png) (CHEMBL3334567)Show SMILES C[C@@H](c1ccc2nccn2c1)n1nnc2ncc(nc12)-c1cnn(C)c1 |r| Show InChI InChI=1S/C17H15N9/c1-11(12-3-4-15-18-5-6-25(15)10-12)26-17-16(22-23-26)19-8-14(21-17)13-7-20-24(2)9-13/h3-11H,1-2H3/t11-/m0/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | <3.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of c-MET D1228V mutant phosphorylation at Tyr1234/Tyr1235 residues in CRISPR/Cas9 modified human NCI-H1993 cells incubated for 4 hrs by HT... |
ACS Med Chem Lett 10: 1322-1327 (2019)
Article DOI: 10.1021/acsmedchemlett.9b00276 BindingDB Entry DOI: 10.7270/Q27W6GKF |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50609348
![PNG](/data/jpeg/tenK5060/BindingDB_50609348.png) (CHEMBL5272595)Show SMILES CN([C@@H]1CCCc2c(ccc(C)c12)-c1ccc2c(C)n[nH]c2c1)C(=O)c1ncccc1C(F)F |r| | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid PDB UniChem
| PDB
| n/a | n/a | n/a | 7.20E+3 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50609349
![PNG](/data/jpeg/tenK5060/BindingDB_50609349.png) (CHEMBL5283603)Show SMILES CN([C@H]1CCCc2c(ccc(C)c12)-c1ccc2c(C)n[nH]c2c1)C(=O)c1ncccc1C(F)F |r| | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50609347
![PNG](/data/jpeg/tenK5060/BindingDB_50609347.png) (CHEMBL5268922)Show SMILES CN(C1CCCc2c(ccc(C)c12)-c1ccc2c(C)n[nH]c2c1)C(=O)c1ncccc1C(F)F | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid PDB UniChem
| PDB
| n/a | n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50609348
![PNG](/data/jpeg/tenK5060/BindingDB_50609348.png) (CHEMBL5272595)Show SMILES CN([C@@H]1CCCc2c(ccc(C)c12)-c1ccc2c(C)n[nH]c2c1)C(=O)c1ncccc1C(F)F |r| | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid PDB UniChem
| PDB
| n/a | n/a | n/a | 650 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50549942
![PNG](/data/jpeg/tenK5054/BindingDB_50549942.png) (CHEMBL4748121) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | n/a | 5.10E+3 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to folded P-loop conformation of wild type N-terminal NH-tagged and avi-tagged dephosphorylated human c-MET (956 to 1390 residues) e... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00392 BindingDB Entry DOI: 10.7270/Q20C50DP |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50549941
![PNG](/data/jpeg/tenK5054/BindingDB_50549941.png) (CHEMBL4744343) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| Purchase
PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | n/a | 9.70E+4 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to folded P-loop conformation of wild type N-terminal NH-tagged and avi-tagged dephosphorylated human c-MET (956 to 1390 residues) e... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00392 BindingDB Entry DOI: 10.7270/Q20C50DP |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50549940
![PNG](/data/jpeg/tenK5054/BindingDB_50549940.png) (CHEMBL4796728) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to folded P-loop conformation of wild type N-terminal NH-tagged and avi-tagged dephosphorylated human c-MET (956 to 1390 residues) e... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00392 BindingDB Entry DOI: 10.7270/Q20C50DP |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50549943
![PNG](/data/jpeg/tenK5054/BindingDB_50549943.png) (CHEMBL4743552) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | n/a | 8.00E+3 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to folded P-loop conformation of wild type N-terminal NH-tagged and avi-tagged dephosphorylated human c-MET (956 to 1390 residues) e... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00392 BindingDB Entry DOI: 10.7270/Q20C50DP |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50549944
![PNG](/data/jpeg/tenK5054/BindingDB_50549944.png) (CHEMBL4747073)Show SMILES O=C1NCc2c(c[nH]c12)-c1cnc2[nH]cc(Cc3ccccc3)c2c1 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Binding affinity to folded P-loop conformation of wild type N-terminal NH-tagged and avi-tagged dephosphorylated human c-MET (956 to 1390 residues) e... |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.0c00392 BindingDB Entry DOI: 10.7270/Q20C50DP |
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50609347
![PNG](/data/jpeg/tenK5060/BindingDB_50609347.png) (CHEMBL5268922)Show SMILES CN(C1CCCc2c(ccc(C)c12)-c1ccc2c(C)n[nH]c2c1)C(=O)c1ncccc1C(F)F | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid PDB UniChem
| PDB
| n/a | n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | ![3D 3D](/images/Docked_3d.png) 3D Structure (crystal) |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50609349
![PNG](/data/jpeg/tenK5060/BindingDB_50609349.png) (CHEMBL5283603)Show SMILES CN([C@H]1CCCc2c(ccc(C)c12)-c1ccc2c(C)n[nH]c2c1)C(=O)c1ncccc1C(F)F |r| | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| | n/a | n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | n/a |
TBA
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Citation and Details
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More data for this Ligand-Target Pair | |