Found 11 hits with Last Name = 'janssen' and Initial = 'co' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50293171
((1R,2S,4S,6E,8S,11R,12R,13S,14R,15R,22R)-13-hydrox...)Show SMILES C[C@H]1[C@H]2CC[C@H](C)\C=C(C)\C[C@@H](C)C[C@H](C)[C@]34OC5=C(C)C(=O)C(=O)C([C@H](O2)[C@H](C)[C@H]1O)=C5[C@H]3OC1(CCN(C)CC1)O4 |r,c:7,18,33| Show InChI InChI=1S/C35H51NO7/c1-18-9-10-25-22(5)28(37)23(6)31(40-25)26-27-32(24(7)29(38)30(26)39)41-35(21(4)17-20(3)16-19(2)15-18)33(27)42-34(43-35)11-13-36(8)14-12-34/h15,18,20-23,25,28,31,33,37H,9-14,16-17H2,1-8H3/b19-15+/t18-,20+,21-,22-,23+,25+,28-,31+,33+,35-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MerLion Pharmaceuticals Pte Ltd
Curated by ChEMBL
| Assay Description
Inhibition of interaction between GST-tagged Bcl-xl and Bak by fluorescence polarization assay |
Bioorg Med Chem Lett 18: 5771-3 (2009)
Article DOI: 10.1016/j.bmcl.2008.09.071
BindingDB Entry DOI: 10.7270/Q2DF6R7B |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50293172
((1R,2S,4S,6E,8S,11R,12R,13S,14R,15R,22R)-13-hydrox...)Show SMILES C[C@H]1[C@H]2CC[C@H](C)\C=C(C)\C[C@@H](C)C[C@H](C)[C@]34OC5=C(C)C(=O)C(=O)C([C@H](O2)[C@H](C)[C@H]1O)=C5[C@H]3OC(C)(C)O4 |r,c:7,18,33| Show InChI InChI=1S/C32H46O7/c1-15-10-11-22-19(5)25(33)20(6)28(36-22)23-24-29(21(7)26(34)27(23)35)37-32(30(24)38-31(8,9)39-32)18(4)14-17(3)13-16(2)12-15/h12,15,17-20,22,25,28,30,33H,10-11,13-14H2,1-9H3/b16-12+/t15-,17+,18-,19-,20+,22+,25-,28+,30+,32+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 9.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MerLion Pharmaceuticals Pte Ltd
Curated by ChEMBL
| Assay Description
Inhibition of interaction between GST-tagged Bcl-xl and Bak by fluorescence polarization assay |
Bioorg Med Chem Lett 18: 5771-3 (2009)
Article DOI: 10.1016/j.bmcl.2008.09.071
BindingDB Entry DOI: 10.7270/Q2DF6R7B |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50293169
(CHEMBL523927 | kendomycin)Show SMILES C[C@H]1[C@H]2CC[C@H](C)\C=C(C)\C[C@@H](C)C[C@H](C)[C@]3(O)OC4=C(C)C(=O)C(=O)C([C@H](O2)[C@H](C)[C@H]1O)C4=C3 |r,c:7,19,36| Show InChI InChI=1S/C29H42O6/c1-14-8-9-22-18(5)24(30)19(6)28(34-22)23-21-13-29(33,17(4)12-16(3)11-15(2)10-14)35-27(21)20(7)25(31)26(23)32/h10,13-14,16-19,22-24,28,30,33H,8-9,11-12H2,1-7H3/b15-10+/t14-,16+,17-,18-,19+,22+,23?,24-,28+,29+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.23E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
MerLion Pharmaceuticals Pte Ltd
Curated by ChEMBL
| Assay Description
Inhibition of interaction between GST-tagged Bcl-xl and Bak by fluorescence polarization assay |
Bioorg Med Chem Lett 18: 5771-3 (2009)
Article DOI: 10.1016/j.bmcl.2008.09.071
BindingDB Entry DOI: 10.7270/Q2DF6R7B |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50293170
((1R,12S,16S,19R,20R,21S,22R)-4,8,21-Trihydroxy-10-...)Show SMILES C[C@@H]1[C@H](O)[C@@H](C)[C@H]2O[C@@H]1CC[C@H](C)\C=C(C)\C[C@@H](C)C[C@H](C)C(=O)C(O)C1=C2C(=O)C(=O)C(C)C1=O |r,c:14,27| Show InChI InChI=1S/C29H42O7/c1-13-8-9-20-17(5)24(31)19(7)29(36-20)22-21(25(32)18(6)26(33)28(22)35)27(34)23(30)16(4)12-15(3)11-14(2)10-13/h10,13,15-20,24,27,29,31,34H,8-9,11-12H2,1-7H3/b14-10+/t13-,15+,16-,17-,18?,19+,20+,24-,27?,29+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.30E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
MerLion Pharmaceuticals Pte Ltd
Curated by ChEMBL
| Assay Description
Inhibition of interaction between GST-tagged Bcl-xl and Bak by fluorescence polarization assay |
Bioorg Med Chem Lett 18: 5771-3 (2009)
Article DOI: 10.1016/j.bmcl.2008.09.071
BindingDB Entry DOI: 10.7270/Q2DF6R7B |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50293169
(CHEMBL523927 | kendomycin)Show SMILES C[C@H]1[C@H]2CC[C@H](C)\C=C(C)\C[C@@H](C)C[C@H](C)[C@]3(O)OC4=C(C)C(=O)C(=O)C([C@H](O2)[C@H](C)[C@H]1O)C4=C3 |r,c:7,19,36| Show InChI InChI=1S/C29H42O6/c1-14-8-9-22-18(5)24(30)19(6)28(34-22)23-21-13-29(33,17(4)12-16(3)11-15(2)10-14)35-27(21)20(7)25(31)26(23)32/h10,13-14,16-19,22-24,28,30,33H,8-9,11-12H2,1-7H3/b15-10+/t14-,16+,17-,18-,19+,22+,23?,24-,28+,29+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 1.83E+6 | n/a | n/a | n/a | n/a | n/a |
MerLion Pharmaceuticals Pte Ltd
Curated by ChEMBL
| Assay Description
Inhibition of interaction between Bcl-xl and Bak by surface plasmon resonance assay |
Bioorg Med Chem Lett 18: 5771-3 (2009)
Article DOI: 10.1016/j.bmcl.2008.09.071
BindingDB Entry DOI: 10.7270/Q2DF6R7B |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM23223
(7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...)Show SMILES CC(C)c1c(O)c(O)c(C=O)c2c(O)c(c(C)cc12)-c1c(C)cc2c(C(C)C)c(O)c(O)c(C=O)c2c1O |(-4.44,-1.63,;-5.78,-.86,;-7.11,-1.63,;-5.78,.68,;-7.11,1.45,;-8.44,.68,;-7.11,2.99,;-8.44,3.76,;-5.78,3.76,;-5.78,5.3,;-4.44,6.07,;-4.44,2.99,;-3.11,3.76,;-3.11,5.3,;-1.77,2.99,;-1.77,1.45,;-.44,.68,;-3.11,.68,;-4.44,1.45,;-.44,3.76,;-.44,5.3,;-1.77,6.07,;.89,6.07,;2.23,5.3,;3.56,6.07,;3.56,7.61,;4.89,8.38,;2.23,8.38,;4.89,5.3,;6.23,6.07,;4.89,3.76,;6.23,2.99,;3.56,2.99,;3.56,1.45,;4.89,.68,;2.23,3.76,;.89,2.99,;.89,1.45,)| Show InChI InChI=1S/C30H30O8/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(22)36/h7-12,33-38H,1-6H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
KEGG
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | 3.38E+5 | n/a | n/a | n/a | n/a | n/a |
MerLion Pharmaceuticals Pte Ltd
Curated by ChEMBL
| Assay Description
Inhibition of interaction between Bcl-xl and Bak by surface plasmon resonance assay |
Bioorg Med Chem Lett 18: 5771-3 (2009)
Article DOI: 10.1016/j.bmcl.2008.09.071
BindingDB Entry DOI: 10.7270/Q2DF6R7B |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM23223
(7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...)Show SMILES CC(C)c1c(O)c(O)c(C=O)c2c(O)c(c(C)cc12)-c1c(C)cc2c(C(C)C)c(O)c(O)c(C=O)c2c1O |(-4.44,-1.63,;-5.78,-.86,;-7.11,-1.63,;-5.78,.68,;-7.11,1.45,;-8.44,.68,;-7.11,2.99,;-8.44,3.76,;-5.78,3.76,;-5.78,5.3,;-4.44,6.07,;-4.44,2.99,;-3.11,3.76,;-3.11,5.3,;-1.77,2.99,;-1.77,1.45,;-.44,.68,;-3.11,.68,;-4.44,1.45,;-.44,3.76,;-.44,5.3,;-1.77,6.07,;.89,6.07,;2.23,5.3,;3.56,6.07,;3.56,7.61,;4.89,8.38,;2.23,8.38,;4.89,5.3,;6.23,6.07,;4.89,3.76,;6.23,2.99,;3.56,2.99,;3.56,1.45,;4.89,.68,;2.23,3.76,;.89,2.99,;.89,1.45,)| Show InChI InChI=1S/C30H30O8/c1-11(2)19-15-7-13(5)21(27(35)23(15)17(9-31)25(33)29(19)37)22-14(6)8-16-20(12(3)4)30(38)26(34)18(10-32)24(16)28(22)36/h7-12,33-38H,1-6H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
KEGG
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | 1.71E+3 | n/a | n/a | n/a | n/a | n/a |
MerLion Pharmaceuticals Pte Ltd
Curated by ChEMBL
| Assay Description
Inhibition of interaction between GST-tagged Bcl-xl and Bak by surface plasmon resonance assay |
Bioorg Med Chem Lett 18: 5771-3 (2009)
Article DOI: 10.1016/j.bmcl.2008.09.071
BindingDB Entry DOI: 10.7270/Q2DF6R7B |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50293171
((1R,2S,4S,6E,8S,11R,12R,13S,14R,15R,22R)-13-hydrox...)Show SMILES C[C@H]1[C@H]2CC[C@H](C)\C=C(C)\C[C@@H](C)C[C@H](C)[C@]34OC5=C(C)C(=O)C(=O)C([C@H](O2)[C@H](C)[C@H]1O)=C5[C@H]3OC1(CCN(C)CC1)O4 |r,c:7,18,33| Show InChI InChI=1S/C35H51NO7/c1-18-9-10-25-22(5)28(37)23(6)31(40-25)26-27-32(24(7)29(38)30(26)39)41-35(21(4)17-20(3)16-19(2)15-18)33(27)42-34(43-35)11-13-36(8)14-12-34/h15,18,20-23,25,28,31,33,37H,9-14,16-17H2,1-8H3/b19-15+/t18-,20+,21-,22-,23+,25+,28-,31+,33+,35-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 3.77E+5 | n/a | n/a | n/a | n/a | n/a |
MerLion Pharmaceuticals Pte Ltd
Curated by ChEMBL
| Assay Description
Inhibition of interaction between GST-tagged Bcl-xl and Bak by surface plasmon resonance assay |
Bioorg Med Chem Lett 18: 5771-3 (2009)
Article DOI: 10.1016/j.bmcl.2008.09.071
BindingDB Entry DOI: 10.7270/Q2DF6R7B |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50293170
((1R,12S,16S,19R,20R,21S,22R)-4,8,21-Trihydroxy-10-...)Show SMILES C[C@@H]1[C@H](O)[C@@H](C)[C@H]2O[C@@H]1CC[C@H](C)\C=C(C)\C[C@@H](C)C[C@H](C)C(=O)C(O)C1=C2C(=O)C(=O)C(C)C1=O |r,c:14,27| Show InChI InChI=1S/C29H42O7/c1-13-8-9-20-17(5)24(31)19(7)29(36-20)22-21(25(32)18(6)26(33)28(22)35)27(34)23(30)16(4)12-15(3)11-14(2)10-13/h10,13,15-20,24,27,29,31,34H,8-9,11-12H2,1-7H3/b14-10+/t13-,15+,16-,17-,18?,19+,20+,24-,27?,29+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | 1.08E+7 | n/a | n/a | n/a | n/a | n/a |
MerLion Pharmaceuticals Pte Ltd
Curated by ChEMBL
| Assay Description
Inhibition of interaction between GST-tagged Bcl-xl and Bak by surface plasmon resonance assay |
Bioorg Med Chem Lett 18: 5771-3 (2009)
Article DOI: 10.1016/j.bmcl.2008.09.071
BindingDB Entry DOI: 10.7270/Q2DF6R7B |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50293169
(CHEMBL523927 | kendomycin)Show SMILES C[C@H]1[C@H]2CC[C@H](C)\C=C(C)\C[C@@H](C)C[C@H](C)[C@]3(O)OC4=C(C)C(=O)C(=O)C([C@H](O2)[C@H](C)[C@H]1O)C4=C3 |r,c:7,19,36| Show InChI InChI=1S/C29H42O6/c1-14-8-9-22-18(5)24(30)19(6)28(34-22)23-21-13-29(33,17(4)12-16(3)11-15(2)10-14)35-27(21)20(7)25(31)26(23)32/h10,13-14,16-19,22-24,28,30,33H,8-9,11-12H2,1-7H3/b15-10+/t14-,16+,17-,18-,19+,22+,23?,24-,28+,29+/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 5.28E+5 | n/a | n/a | n/a | n/a | n/a |
MerLion Pharmaceuticals Pte Ltd
Curated by ChEMBL
| Assay Description
Inhibition of interaction between GST-tagged Bcl-xl and Bak by surface plasmon resonance assay |
Bioorg Med Chem Lett 18: 5771-3 (2009)
Article DOI: 10.1016/j.bmcl.2008.09.071
BindingDB Entry DOI: 10.7270/Q2DF6R7B |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50293171
((1R,2S,4S,6E,8S,11R,12R,13S,14R,15R,22R)-13-hydrox...)Show SMILES C[C@H]1[C@H]2CC[C@H](C)\C=C(C)\C[C@@H](C)C[C@H](C)[C@]34OC5=C(C)C(=O)C(=O)C([C@H](O2)[C@H](C)[C@H]1O)=C5[C@H]3OC1(CCN(C)CC1)O4 |r,c:7,18,33| Show InChI InChI=1S/C35H51NO7/c1-18-9-10-25-22(5)28(37)23(6)31(40-25)26-27-32(24(7)29(38)30(26)39)41-35(21(4)17-20(3)16-19(2)15-18)33(27)42-34(43-35)11-13-36(8)14-12-34/h15,18,20-23,25,28,31,33,37H,9-14,16-17H2,1-8H3/b19-15+/t18-,20+,21-,22-,23+,25+,28-,31+,33+,35-/m0/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 3.99E+5 | n/a | n/a | n/a | n/a | n/a |
MerLion Pharmaceuticals Pte Ltd
Curated by ChEMBL
| Assay Description
Inhibition of interaction between Bcl-xl and Bak by surface plasmon resonance assay |
Bioorg Med Chem Lett 18: 5771-3 (2009)
Article DOI: 10.1016/j.bmcl.2008.09.071
BindingDB Entry DOI: 10.7270/Q2DF6R7B |
More data for this
Ligand-Target Pair | |
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