Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591225 (2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7-fl...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591249 (2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7-fl...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591137 (2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7- f...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591222 (2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7-fl...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591220 (2-((8-amino-6-(5-amino-4-ethylpyridin- 3-yl)-7-flu...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591244 ((S)-2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591242 (2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7-fl...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591240 (2-((8-amino-6-(5-amino-4- chloropyridin-3-yl)-7-fl...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591144 ((1R,2S,3R)-N-(8-amino-7-fluoro-6-(8-methyl-2,3-dih...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591146 (US11566003, Compound 35) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591155 (US11566003, Compound 111) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591137 (2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7- f...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591217 (2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7-fl...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591211 (2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7-fl...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591252 (2-((8-amino-7-fluoro-6-(4-methyl-6- (oxazol-2-yl)p...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591250 (2'-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7-f...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591147 (US11566003, Compound 36) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591143 (1-(8-amino-7-fluoro-6-(8-methyl- 2,3-dihydro-1H-py...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50327601 (6-(3-(4-(8-fluoronaphthalen-1-yl)piperazin-1-yl)pr...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0141 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HeLa cells | Bioorg Med Chem Lett 20: 5666-9 (2010) Article DOI: 10.1016/j.bmcl.2010.08.023 BindingDB Entry DOI: 10.7270/Q2HH6K9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591246 (2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7-fl...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591136 (2'-((8-amino-7-fluoro-6-(4- methylpyridin-3-yl)iso...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591136 (2'-((8-amino-7-fluoro-6-(4- methylpyridin-3-yl)iso...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. The solut... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
5-hydroxytryptamine receptor 1A (Homo sapiens (Human)) | BDBM50327602 (6-(3-(4-(naphthalen-1-yl)piperazin-1-yl)propoxy)is...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 0.0152 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Displacement of [3H]-8-OH-DPAT from human 5HT1A receptor expressed in HeLa cells | Bioorg Med Chem Lett 20: 5666-9 (2010) Article DOI: 10.1016/j.bmcl.2010.08.023 BindingDB Entry DOI: 10.7270/Q2HH6K9S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591141 (US11566003, Compound 11) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591177 (2-((8-amino-6-(5-amino-4- chloropyridin-3-yl)-7-fl...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591139 (US11566003, Compound 9) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591243 ((R)-2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591232 (2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7-fl...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591233 (2-((8-amino-6-(5-amino-4,6- dimethylpyridin-3-yl)-...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591167 (2-((8-amino-7-fluoro-6-(8-methyl-2,3- dihydro-1H-p...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB US Patent | 0.0180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591239 (2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7-fl...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM503940 (1-(3-(4-(8-amino-6-(4-methylpyridin-3- yl)-2,7-nap...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th... | Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM503914 ((1S,2S)-N-(8-amino-5-fluoro-6-(4- methylpyridin-3-...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th... | Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM504062 ((1R,2R)-N-(8-amino-6-(4-methylpyridin- 3-yl)-2,7-n...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <0.0200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th... | Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM504051 ((1S,2S)N-(8-amino-6-(4-methyl-2-phenylpyridi...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th... | Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM504049 ((1R,2S)N-(8-amino-5-cyclopropyl-6-(4-methylp...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th... | Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM504044 (US11034692, Compound 313) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th... | Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM503988 (2-[[8-amino-6-(4-methylpyridin-3-yl)-2,7- naphthyr...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th... | Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM503879 (1-[3-[4-[[8-amino-6-(4-methyl-3-pyridyl)- 2,7-naph...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th... | Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM503863 (US11034692, Compound 146 | trans-N-[8-amino-6-(4-m...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th... | Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591272 (US11566003, Compound 339) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591273 (US11566003, Compound 340) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591148 (US11566003, Compound 53 | tetrahydro-2H-pyran-4-yl...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM503999 (3-[[8-Amino-6-(4-methylpyridin-3-yl)-2,7- naphthyr...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th... | Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591168 (2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7-fl...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM503978 (US11034692, Compound 247) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Lanth: For the binding assay, 4 ul 2×HPK1 and Eu-anti-GST antibody were added to each well of the assay plate using a Multidrop reagent dispenser. Th... | Citation and Details BindingDB Entry DOI: 10.7270/Q2CV4MW8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591237 ((E)-2-((8-amino-7-fluoro-6-(4- methylpyridin-3-yl)...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591169 (2-((8-amino-6-(5-amino-4- methylpyridin-3-yl)-7-fl...) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591145 (US11566003, Compound 34) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0250 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase kinase kinase kinase 1 (Homo sapiens (Human)) | BDBM591213 (US11566003, Compound 279) | PDB NCI pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.0260 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description To a 384 well Proxiplate with 80 nL compound or DMSO spotted on was added 4 μl/well kinase mix. The mixture was preincubated for 30 minutes and ... | Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0ZFV | |||||||||||
More data for this Ligand-Target Pair |
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